|1.||Panic Disorder (Panic Attack)
|3.||Anxiety Disorders (Anxiety Disorder)
|4.||Obsessive-Compulsive Disorder (Disorder, Obsessive-Compulsive)
|5.||Phobic Disorders (Phobia)
|1.||Nardi, Antonio E: 26 articles (01/2014 - 09/2002)|
|2.||Pollack, Mark H: 22 articles (12/2014 - 05/2002)|
|3.||Nascimento, Isabella: 22 articles (02/2012 - 06/2002)|
|4.||Deckert, Jürgen: 20 articles (07/2015 - 09/2003)|
|5.||Valença, Alexandre M: 20 articles (02/2012 - 06/2002)|
|6.||Domschke, Katharina: 19 articles (10/2015 - 01/2004)|
|7.||Otto, Michael W: 18 articles (07/2015 - 05/2002)|
|8.||Freire, Rafael C: 17 articles (03/2013 - 09/2005)|
|9.||Zangrossi, Hélio: 16 articles (02/2016 - 07/2002)|
|10.||Perna, Giampaolo: 16 articles (04/2015 - 06/2002)|
|1.||Alprazolam (Xanax)FDA LinkGeneric
08/01/1993 - "These results suggest that sustained-release alprazolam is highly effective in the acute treatment of panic disorder at doses comparable to those in the originally marketed compressed tablet of alprazolam. "
12/01/1984 - "Blockade of panic attacks with TCAs, MAOIs and alprazolam has dramatically improved our ability to treat these disorders, with 60 to 95 per cent of patients reporting marked alleviation of symptoms. "
06/01/1986 - "Alprazolam treatment led to a complete remission of panic attacks in 85% of the patients; panics ceased within an average of 6 days, at a mean dose of 2.2 mg/day. "
10/01/1993 - "Studies of plasma alprazolam concentration versus clinical response during short-term treatment of panic disorder indicate that therapeutic response at steady-state plasma levels of 20 to 40 ng/mL is significantly greater than at levels less than 20 ng/mL. Substantial additional benefit from plasma levels greater than 40 ng/mL is not consistently demonstrated. "
04/01/1992 - "A recently reported multinational, 8-week double-blind, placebo-controlled study assessing the efficacy of alprazolam versus placebo in the treatment of panic disorder indicated significant differences favoring alprazolam. "
01/01/1986 - "Which are improved by benzodiazepines which; themselves, have very little effect on panic attacks."
10/01/1993 - "In this controlled, randomized trial the authors investigated the efficacy of a cognitive-behavioral program for patients with panic disorder who were attempting to discontinue treatment with high-potency benzodiazepines. "
01/01/2009 - "The review established the paucity of high quality evidence investigating the efficacy of psychotherapy combined with benzodiazepines for panic disorder. "
01/01/2002 - "There is consistent support for the efficacy of cognitive-behavior therapy (CBT) to aid the successful discontinuation of benzodiazepine (BZ) medication in patients with panic disorder, and help these individuals maintain treatment gains while off medication. "
05/01/1990 - "The high-potency benzodiazepines have been effective in short-term treatment of panic disorder, but systematic investigation of their long-term efficacy and safety is necessary. "
|3.||Imipramine (Janimine)FDA LinkGeneric
06/01/1998 - "Imipramine has proven efficacy for panic disorder. "
12/01/2001 - "Emotion-focused psychotherapy was less effective for symptoms of panic disorder than treatment with either cognitive behavior therapy or imipramine; results obtained with emotion-focused psychotherapy after the acute and maintenance phases were similar to those seen with placebo. "
08/01/2014 - "The results suggest that low-dose imipramine may be useful for the treatment of panic disorder during pregnancy. "
11/01/1987 - "Ten of the patients improved markedly on imipramine in an open drug trial design which lasted 3 months; the two non-responders had both situational and spontaneous panic attacks. "
02/01/2007 - "The authors assessed whether adding cognitive behavior therapy (CBT) to imipramine for patients with panic disorder decreased the severity of side effects and dropouts from side effects. "
|4.||Antidepressive Agents (Antidepressants)IBA
05/01/1986 - "This would be consistent with the fact that most antidepressant drugs are effective in preventing panic attacks. "
01/01/2007 - "Antidepressants have been demonstrated to be effective in preventing panic attacks, and in improving anticipatory anxiety and avoidance behaviour. "
10/16/2006 - "Antidepressant drugs are effective in the treatment of panic in human panic disorder patients. "
03/01/1999 - "Antidepressant drugs are effective in anxiety states, including panic disorder. "
05/01/1992 - "Antidepressants seem effective in cases of mixed anxiety-depression or panic disorder. "
|5.||Serotonin (5 Hydroxytryptamine)IBA
09/09/1996 - "Among the TCAs, those with an effect on serotonin reuptake are most effective in panic disorder. "
07/17/2000 - "Do selective serotonin re-uptake inhibitors enhance the efficacy of very brief cognitive behavioral therapy for panic disorder? "
09/01/2004 - "Selective serotonin re-uptake inhibitor (SSRI) is effective for depression and panic disorders. "
07/01/1999 - "This suggests that increased levels of serotonin are necessary in the synapse for the SSRI to be effective in the treatment of depression and panic disorder. "
11/01/1993 - "(5) Are serotonin selective uptake inhibitors (SSUIs) effective in panic disorder via the serotonin system or some other mechanism? "
|6.||Paroxetine (Paxil)FDA LinkGeneric
02/01/1997 - "Paroxetine was statistically significantly more effective than placebo throughout the long-term study with respect to reduction from baseline of full panic attacks, and at the end of treatment with respect to the proportion of patients who eventually experienced no panic attacks. "
09/01/1999 - "Paroxetine treatment (19.7 +/- 4.7 mg/day for 105 +/- 37 days) resulted in a significant improvement in the frequency and intensity of panic attacks and also on the state anxiety inventory. "
01/01/1998 - "In a 12-week double-blind study of 120 panic patients receiving standardised cognitive therapy, paroxetine was significantly more effective than placebo in reducing panic attack frequency. "
09/01/1995 - "Paroxetine plus cognitive therapy was significantly more effective than placebo plus cognitive therapy in the treatment of panic disorder."
01/01/1998 - "This study was designed to determine the minimum paroxetine dose effective for treating panic disorder. "
|7.||Serotonin Uptake Inhibitors (Serotonin Reuptake Inhibitors)IBA
10/01/2000 - "The discussion underscores the need for more methodologically improved comparative studies with selective serotonin reuptake inhibitors in the treatment of panic disorder."
02/01/2007 - "Selective serotonin reuptake inhibitors are thought to interact with serotonergic neurons and be effective for treatment of panic disorder. "
09/01/2002 - "Both cognitive-behavioral therapy and treatment with selective serotonin reuptake inhibitors (SSRIs) have proved to be effective in the treatment of panic disorder. "
12/01/2001 - "Although serotonin reuptake inhibitors are effective in panic disorder, questions concerning whether doses associated with antidepressant efficacy are also effective for panic disorder remain. "
04/01/1998 - "Of the therapeutic options available, there is mounting evidence that selective serotonin reuptake inhibitors (SSRIs) represent reasonable monotherapy for patients with comorbid depression and panic disorder, based on the equivalent efficacy and improved side-effect profiles compared with other classes of antidepressant. "
|8.||Clonazepam (Rivotril)FDA LinkGeneric
03/05/2003 - "In the group that received clonazepam, by the end of the 6th week there was a statistically significant clinical improvement, shown by the remission of panic attacks (p < 0.001) and decrease in anxiety (p = 0.024). "
03/05/2003 - "Clonazepam was equally effective in the treatment of the respiratory and non-respiratory subtypes of panic disorder, suggesting there is no difference in the therapeutic response between the two subtypes."
05/01/1991 - "Clonazepam was administered in relatively low doses and, after four weeks, was shown to be effective in reducing the number of panic attacks and associated features of the disorder."
05/01/2006 - "The efficacy of clonazepam monotherapy for the short-term treatment of panic disorder (PD) was fully established in two large pivotal multicentre studies in the late 1990s in a total of >800 patients. "
03/05/2003 - "To evaluate the clinical efficacy of clonazepam in a fixed dosage (2 mg/day), compared to placebo, in the treatment of panic disorder patients and to verify whether there are any differences in the responses to clonazepam between panic disorder patients with the respiratory and non-respiratory subtypes. "
|9.||Monoamine Oxidase Inhibitors (Monoamine Oxidase Inhibitor)IBA
01/01/1989 - "Monoamine oxidase inhibitors are effective in the treatment of panic attacks. "
09/01/1992 - "Monoamine oxidase inhibitors may be particularly helpful in patients with panic disorder who exhibit social avoidance. "
03/01/1995 - "It is generally thought that atypical depression would respond better to monoamine oxidase inhibitors (MAOI), but it would seem that it is mainly major depression associated with panic disorder that could predict this kind of response to treatment. "
01/01/1992 - "The monoamine oxidase inhibitors have also proved very useful in the treatment of panic disorder and social phobia, but probably should be used only by physicians with experience with this type of medication."
01/01/1990 - "In addition to being effective in depressive disorders, monoamine oxidase inhibitors (MAOIs) have been shown to be effective in controlled studies of patient with panic disorder with agoraphobia, social phobia, atypical depression or mixed anxiety and depression, bulimia, posttraumatic stress disorder (PTSD) and borderline personality disorder. "
|10.||Clomipramine (Anafranil)FDA LinkGeneric
09/01/1981 - "These results support the claim that chlomipramine is highly effective in preventing recurrence of panic attacks."
05/01/1998 - "These results suggest that regular aerobic exercise alone, in comparison with placebo, is associated with significant clinical improvement in patients suffering from panic disorder, but that it is less effective than treatment with clomipramine."
05/01/1991 - "Clomipramine at low doses is also effective in the treatment of panic disorder and has been used successfully in the treatment of premature ejaculation."
01/01/1999 - "Several placebo-controlled trials have shown the efficacy of clomipramine (CMI) in panic disorder. "
01/01/1993 - "[The clinico-psychopathological characteristics of patients with panic disorders and the efficacy of clomipramine therapy]."
|1.||Drug Therapy (Chemotherapy)
12/01/1995 - "Studies of patients followed up after acute pharmacotherapy trials and those treated naturalistically are consistent with this model and portray panic disorder as a generally chronic condition with a longitudinal course marked by relatively brief intervals of remission and high rates of recurrence and relapse. "
05/01/2002 - "Long-term outcome was examined for 78 patients who attained a 2-month period of sustained remission on medication and received maintenance pharmacotherapy for up to 24 months during the Massachusetts General Hospital Longitudinal Study of Panic Disorder, a prospective, naturalistic study. "
04/01/2008 - "To establish whether the combination of cognitive-behavioral therapy (CBT) and pharmacotherapy (SSRI) was more effective in treating panic disorder (PD) than either CBT or SSRI alone, and to evaluate any differential effects between the mono-treatments. "
08/01/2006 - "The comparable response of poor individuals in this study suggests that standard CBT and pharmacotherapy treatments for panic disorder do not need to be "tailored" to be effective in poor populations. "
05/01/1994 - "The purpose of this pilot study is to assess the efficacy of cognitive behavior therapy for the treatment of patients with panic disorder who experience an incomplete response to a trial of pharmacotherapy. "
01/01/2010 - "Patients in both treatment conditions showed significant improvement on the main outcome measure, the Panic Disorder Severity Scale (PDSS) after treatment. "
01/01/1997 - "Ratings after treatment demonstrated both a statistically significant reduction in panic symptoms and a diminution in the number of panic attacks compared with baseline ratings. "
01/01/2011 - "The aim of our study is to measure very low frequency band (VLF), low frequency band (LF) and high frequency band (HF) components of R-R interval during orthostatic experiment in patients with panic disorder before and after treatment and compares it with healthy controls. "
01/01/2013 - "Panic disorder symptoms are persistent for 50-80% of cases even after treatment, resulting in experiences of disability and dissatisfaction in life. "
03/15/2008 - "Temperament and character were evaluated in patients with panic disorder (PD) before and after 1 year of pharmacological therapy to verify whether personality characteristics change after treatment. "
01/01/2011 - "Bibliotherapy is potentially effective in the treatment of panic disorder (PD). "
09/01/2010 - "Expanding the limits of bibliotherapy for panic disorder: randomized trial of self-help without support but with a clear deadline."
06/01/2005 - "The present study investigated the effectiveness of bibliotherapy and minimal therapist-contact interventions in the treatment of panic attacks. "
09/01/2000 - "The present study examined a relapse prevention (RP) program delivered via bibliotherapy in the treatment of individuals with panic attacks. "
01/01/2011 - "A randomized controlled trial comparing two ways to deliver bibliotherapy for panic disorder."
|4.||Phototherapy (Light Therapy)
02/01/1992 - "Moreover, since administration of artificial bright light therapy is currently the most effective treatment for SAD, it is suggested that patients with panic disorder should be questioned as to whether their symptoms are seasonally related. "
06/01/1994 - "These findings suggest the possibility of a common aetiology for panic disorder and SAD, that seasonality may be a far more general phenomenon in psychopathology, and that light therapy may be a useful treatment for some panic disorder patients."
05/04/1991 - "Seasonal panic disorder responsive to light therapy."
06/30/1997 - "Recently it has been reported that not only depression, but also panic disorder and obsessive compulsive disorders may exhibit a seasonal pattern and thus benefit from phototherapy. "
01/01/1991 - "This study provides further evidence for the efficacy of hypnosis in the elimination of panic attacks."
01/01/1991 - "In this case study, hypnosis combined with progressive relaxation effectively eliminated the cause of panic attacks in a 34 year old female. "
06/01/2014 - "One (0.4%) of 238 patients in the hypnosis group dropped out due to an adverse event (panic attack). "
04/01/2005 - "Awake-alert hypnosis in the treatment of panic disorder: a case report."
04/01/1995 - "A 52-year-old woman with a 27-year history of panic attacks and sleep disorder inadvertently recovered incest memories in hypnosis. "