Amyloid beta-Protein Precursor (Amyloid Protein Precursor)
A precursor to the AMYLOID BETA-PROTEIN (beta/A4). Alterations in the expression of the amyloid beta-protein precursor (ABPP) gene, located on chromosome 21, plays a role in the development of the neuropathology common to both ALZHEIMER DISEASE and DOWN SYNDROME. ABPP is associated with the extensive extracellular matrix secreted by neuronal cells. Upon cleavage, this precursor produces three proteins of varying amino acid lengths: 695, 751, and 770. The beta/A4 (695 amino acids) or beta-amyloid protein is the principal component of the extracellular amyloid in senile plaques found in ALZHEIMER DISEASE; DOWN SYNDROME and, to a limited extent, in normal aging.
Also Known As:
Amyloid Protein Precursor; Amyloid beta Precursor Protein; Amyloid beta Protein Precursor; beta Amyloid Protein Precursor; beta-Protein Precursor, Amyloid; Amyloid A4 Protein Precursor; beta-Amyloid Protein Precursor
Networked: 374
relevant articles (1 outcomes,
22 trials/studies)
for this Bio-Agent,
Comments
Relationship Network
Bio-Agent Context: Research Results
- Amino Acids, Peptides, and Proteins
- Proteins: 58375
- Amyloid: 14317
- Amyloid beta-Protein: 1292
- Amyloid beta-Protein Precursor: 374
- protease nexins: 27
- APP717: 25
- appican: 5
- amyloid precursor protein carboxyl-terminal fragment gamma: 1
- APP63-73: 1
- amyloid beta-protein precursor 695 (18-38)
- amyloid beta-protein precursor 695 (319-339)
- amyloid beta-protein precursor 695 (681-695)
- amyloid beta-protein precursor 770 (301-323)
- amyloid beta-protein precursor 770 (681-695)
- amyloid beta-protein precursor 770 (713-730)
- amyloid beta-protein precursor CT105
- carboxy-terminal 100 residues amyloid precursor protein
- human alpha-sAPP protein
- human amyloid beta-protein precursor C-terminal fragment beta
- human APLP1 protein
- human APLP2 protein
- human beta-sAPP protein
- human betaA4 amyloid precursor protein (139-157)
- human CTFgamma protein
- mouse Aplp1 protein
- mouse Aplp2 protein
- rat Aplp2 protein
- rat CTFgamma protein
- recombinant SPA4CT protein
- Amyloid beta-Protein Precursor: 374
- Amyloid beta-Protein: 1292
- Protein Precursors: 24
- Amyloid beta-Protein Precursor: 374
- protease nexins: 27
- APP717: 25
- appican: 5
- amyloid precursor protein carboxyl-terminal fragment gamma: 1
- APP63-73: 1
- amyloid beta-protein precursor 695 (18-38)
- amyloid beta-protein precursor 695 (319-339)
- amyloid beta-protein precursor 695 (681-695)
- amyloid beta-protein precursor 770 (301-323)
- amyloid beta-protein precursor 770 (681-695)
- amyloid beta-protein precursor 770 (713-730)
- amyloid beta-protein precursor CT105
- carboxy-terminal 100 residues amyloid precursor protein
- human alpha-sAPP protein
- human amyloid beta-protein precursor C-terminal fragment beta
- human APLP1 protein
- human APLP2 protein
- human beta-sAPP protein
- human betaA4 amyloid precursor protein (139-157)
- human CTFgamma protein
- mouse Aplp1 protein
- mouse Aplp2 protein
- rat Aplp2 protein
- rat CTFgamma protein
- recombinant SPA4CT protein
- Amyloid beta-Protein Precursor: 374
- Amyloid: 14317
- Proteins: 58375
Experts
| 1. | D'Adamio, Luciano: 8 articles (02/2009 - 02/2002) |
| 2. | Smith, Mark A: 7 articles (01/2010 - 09/2002) |
| 3. | Perry, George: 7 articles (01/2010 - 09/2002) |
| 4. | Wolfe, Michael S: 7 articles (07/2008 - 08/2002) |
| 5. | Lahiri, Debomoy K: 5 articles (02/2010 - 10/2002) |
| 6. | Small, David H: 5 articles (04/2005 - 01/2002) |
| 7. | Zhu, Xiongwei: 4 articles (01/2010 - 09/2002) |
| 8. | Van Nostrand, William E: 4 articles (04/2009 - 11/2002) |
| 9. | Koo, Edward H: 4 articles (02/2008 - 11/2003) |
| 10. | Engel, W King: 4 articles (11/2007 - 03/2003) |
Related Diseases
Related Drugs and Biologics
Related Therapies and Procedures
| 1. | Denervation
|
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