Amyloid beta-Protein Precursor (Amyloid Protein Precursor)

A single-pass type I membrane protein. It is cleaved by AMYLOID PRECURSOR PROTEIN SECRETASES to produce peptides of varying amino acid lengths. A 39-42 amino acid peptide, AMYLOID BETA-PEPTIDES is a principal component of the extracellular amyloid in SENILE PLAQUES.

Also Known As:

Amyloid Protein Precursor; Amyloid beta Precursor Protein; Protease Nexin 2; Protease Nexin II; Amyloid beta Protein Precursor; Nexin 2, Protease; Nexin II, Protease; beta Amyloid Protein Precursor; beta-Protein Precursor, Amyloid; Amyloid A4 Protein Precursor; beta-Amyloid Protein Precursor

Networked: 519 relevant articles (1 outcomes, 36 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843

Experts

1.	Pluta, Ryszard: 14 articles (06/2022 - 12/2016)
2.	Januszewski, Sławomir: 10 articles (12/2021 - 12/2016)
3.	D'Adamio, Luciano: 10 articles (07/2010 - 04/2001)
4.	Czuczwar, Stanisław J: 9 articles (12/2021 - 12/2016)
5.	Wolfe, Michael S: 8 articles (01/2021 - 08/2002)
6.	Ułamek-Kozioł, Marzena: 8 articles (06/2020 - 12/2016)
7.	Small, David H: 7 articles (06/2019 - 01/2002)
8.	Perry, George: 7 articles (01/2010 - 09/2002)
9.	Smith, Mark A: 7 articles (01/2010 - 09/2002)
10.	Lahiri, Debomoy K: 6 articles (02/2010 - 10/2002)

Related Diseases

1.	Alzheimer Disease (Alzheimer's Disease) 05/01/1993 - "Studies comparing the expression of the amyloid beta protein precursor (APP) gene in brains of patients with Alzheimer's disease (AD) and control individuals have resulted in contradictory findings indicative of selective reductions and relative increases of APP alternative transcripts in AD brain. " 01/01/1991 - "Studies of amyloid beta-protein precursor expression in Alzheimer's disease." 12/01/1988 - "By further study of the amyloid protein precursor gene, laboratory diagnosis and eventual treatment of Alzheimer's disease may become a reality. " 02/01/2022 - "The amyloid beta precursor protein (APP) plays a pathophysiological role in the development of Alzheimer's disease as well as a physiological role in neuronal growth and synaptogenesis. " 01/01/2022 - "Clinical characteristics and genotype-phenotype correlation analysis of familial Alzheimer's disease patients with pathogenic/likely pathogenic amyloid protein precursor mutations."
2.	Amyloidosis 08/01/2001 - "APPsw transgenic mice (Tg2576) overproducing mutant amyloid beta protein precursor (betaAPP) show substantial brain Abeta amyloidosis and behavioural abnormalities. " 01/01/2000 - "Common treatments of amyloidoses are based on decreasing the availability of the amyloid protein precursor. " 06/01/1991 - "Homology of the amyloid beta protein precursor in monkey and human supports a primate model for beta amyloidosis in Alzheimer's disease." 01/01/2016 - "Transgenic mouse models carrying genetic mutations of amyloid protein precursor (APP) and presenilin-1 (PS1) are commonly used to assess the pharmacodynamics of potential amyloidosis-lowering and pro-cognitive compounds. " 10/13/2000 - "Impaired neurotransmitter systems by Abeta amyloidosis in APPsw transgenic mice overexpressing amyloid beta protein precursor."
3.	Neuroblastoma 01/01/2011 - "All four compounds protected MC65 neuroblastoma cells from amyloid beta protein precursor C-terminal fragment (APP CTF)-induced neurotoxicity. " 06/01/2008 - "Exogenous CoQ protected MC65 neuroblastoma cells from amyloid-beta protein precursor C-terminal fragment (APP CTF)-induced neurotoxicity in a concentration dependent manner, with concentrations of 6.25 microM and higher providing near complete protection. " 01/01/1994 - "The toxic effect of Alzheimer amyloid protein precursor overexpressed in the neuroblastoma cell line NB-1 on neurite outgrowth." 09/21/2023 - "This study investigated the neuro-promoting effects of cordycepin on amyloid-beta precursor protein (APP) synthesis in human neuroblastoma SH-SY5Y cells. " 10/01/1996 - "We have established a stably transformed human neuroblastoma cell line (MC65) that conditionally expresses a C-terminal derivative of the amyloid beta protein precursor (beta PP) termed S beta C (a fusion protein composed of the amino-17 and carboxyl-99 residues of beta PP). "
4.	Amyloid Plaque 03/19/1999 - "The principal component of Alzheimer's amyloid plaques, Abeta, derives from proteolytic processing of the Alzheimer's amyloid protein precursor (APP). " 05/01/1993 - "Nonisotopic in situ hybridization of amyloid beta protein precursor in Alzheimer's disease: expression in neurofibrillary tangle bearing neurons and in the microenvironment surrounding senile plaques." 03/31/1993 - "In Alzheimer's disease a small fragment of the amyloid protein precursor (APP), called beta 4, is a characteristic component of senile plaques in brains of affected patients. " 03/26/1990 - "Amyloid beta-protein precursor accumulates in dystrophic neurites of senile plaques in Alzheimer-type dementia." 01/01/2020 - "As a result, in PD, the aggregation of α-synuclein is disrupted, which leads to the formation of Levi bodies, and in AD, the amyloid beta precursor protein (APP) undergoes proteolysis and this leads to the formation of amyloid plaques, which triggers subsequent neurodegenerative changes, including the death of neurons. "
5.	Brain Ischemia (Cerebral Ischemia) 06/27/1994 - "The distribution of beta-amyloid protein precursor (APP) was investigated immunocytochemically in rats subjected to global cerebral ischemia (GCI) induced by cardiac arrest. " 07/06/2005 - "To observe the expression of amyloid beta precursor protein and amyloid beta protein in neurons of hippocampal CA1 region after brain ischemia in human. " 02/01/2020 - "We used a rat model to study changes in gene expression of the amyloid protein precursor and its cleaving enzymes and tau protein in the hippocampal CA3 sector, after transient 10-min global brain ischemia with survival times of 2, 7, and 30 days. " 01/01/2019 - "More recently, brain ischemia has been shown to elicit Alzheimer's disease neuropathologic change, possibly facilitating the development of dementia due to the amyloidogenic processing of Alzheimer's disease-related amyloid protein precursor into amyloid. " 02/28/2021 - "In this review, we summarize protein alterations associated with Alzheimer's disease and their gene expression (amyloid protein precursor and tau protein) after cerebral ischemia, as well as their roles in post-ischemic hippocampus neurodegeneration. "

Related Drugs and Biologics

1.	Peptide Hydrolases (Proteases)
2.	Amyloid beta-Peptides
3.	Amyloid Precursor Protein Secretases (beta-Secretase)
4.	Proteins (Proteins, Gene)
5.	Enzymes
6.	tau Proteins (tau Protein)
7.	Peptides (Polypeptides)
8.	Presenilin-1
9.	Presenilins
10.	Amyloid (Amyloid Fibrils)

Related Therapies and Procedures

1.	Enzyme Replacement Therapy
2.	Denervation