|1.||Kozielski, Frank: 8 articles (06/2013 - 01/2007)|
|2.||Engle, Elizabeth C: 6 articles (04/2014 - 12/2003)|
|3.||Gallie, Brenda L: 6 articles (01/2014 - 02/2002)|
|4.||Corson, Timothy W: 5 articles (03/2014 - 09/2006)|
|5.||Mandi, Yvette: 5 articles (09/2009 - 01/2007)|
|6.||Somogyvari, Ferenc: 5 articles (09/2009 - 01/2007)|
|7.||Kondacs, Andras: 5 articles (09/2009 - 01/2007)|
|8.||Szolnoki, Zoltan: 5 articles (09/2009 - 01/2007)|
|9.||Chan, Wai-Man: 4 articles (04/2014 - 12/2003)|
|10.||Nakamura, Yusuke: 4 articles (08/2013 - 01/2005)|
05/01/2010 - "The polymorphism Trp719Arg in the kinesin-like protein 6 is associated with the presence of late outgrowth endothelial progenitor cells in acute myocardial infarction."
01/01/2010 - "As a result of several genoms wide association studies the role of polymorphic marker Thr719Arg of kinesin 6 gene in development of ischemic heart disease, myocardial infarction, and in efficacy of therapy with statins was revealed."
01/29/2008 - "Association of the Trp719Arg polymorphism in kinesin-like protein 6 with myocardial infarction and coronary heart disease in 2 prospective trials: the CARE and WOSCOPS trials."
|2.||Prostatic Neoplasms (Prostate Cancer)
01/01/2012 - "The mitotic centromere-associated kinesin (MCAK) was identified as a novel mitosis-phase target in prostate cancer that was overexpressed in multiple CRPC gene-expression datasets. "
01/01/2012 - "Mitosis phase enrichment with identification of mitotic centromere-associated kinesin as a therapeutic target in castration-resistant prostate cancer."
09/15/2014 - "Nuclear Eg5 (kinesin spindle protein) expression predicts docetaxel response and prostate cancer aggressiveness."
09/01/2008 - "In this study, we sought to assess the efficacy of ispinesib, a mitotic kinesin spindle protein (KSP) inhibitor in androgen-independent prostate cancer progressing after docetaxel. "
01/01/2014 - "Microtubule-targeting agents such as taxanes, docetaxel and paclitaxel, have enjoyed success in the treatment of metastatic prostate cancer; although new, recently designed mitosis-specific agents, such as the polo-kinase and kinesin-inhibitors, have yielded clinically disappointing results. "
|3.||Myocardial Ischemia (Ischemic Heart Diseases)
04/01/2015 - "First-in-human phase 1 study of filanesib (ARRY-520), a kinesin spindle protein inhibitor, in patients with advanced solid tumors."
08/01/2013 - "Phase II study to assess the efficacy, safety and tolerability of the mitotic spindle kinesin inhibitor AZD4877 in patients with recurrent advanced urothelial cancer."
11/01/2015 - "Kinesin superfamily protein 2A (KIF2A), an M‑type nonmotile microtubule depolymerase, has received attention for its role in carcinogenesis and prognostic value in several types of cancer. "
10/01/2015 - "There is emerging evidence that Kinesin family member 7 (Kif7) promotes Hedgehog (Hh) signaling during embryonic development, and its misregulation contributes to diseases such as ciliopathies and cancer. "
04/01/2015 - "Purpose Filanesib (ARRY-520) is a highly selective, targeted inhibitor of kinesin spindle protein (KSP) inhibitor that induces mitotic arrest and subsequent tumor cell death. "
|5.||Breast Neoplasms (Breast Cancer)
01/01/2008 - "Among the dozens of transactivated genes, in the present study we focused on the functional significance of kinesin family member 2C (KIF2C)/mitotic centromere-associated kinesin (MCAK) in the growth of breast cancer cells. "
12/01/2015 - "To investigate the expression of targeting protein for Xenopus kinesin-like protein 2 (TPX2) in breast cancer tissue and to explore its role in proliferation, migration and invasion of breast cancer cells. "
10/01/2015 - "We investigated these questions using both a vesicular transport human kinesin, kinesin-1, and also a mitotic kinesin likely optimized for group function, kinesin-5, moving along either bovine brain or MCF7(breast cancer) MTs. "
01/01/2015 - "Impact of kinesin Eg5 inhibition by 3,4-dihydropyrimidin-2(1H)-one derivatives on various breast cancer cell features."
08/01/2014 - "Chemogenetic evaluation of the mitotic kinesin CENP-E reveals a critical role in triple-negative breast cancer."
|3.||Proteins (Proteins, Gene)
|7.||R-SNARE Proteins (Vesicle-Associated Membrane Protein)
|8.||Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
|10.||4- (2,5- difluorophenyl)- N- (3- fluoro- 1- methylpiperidin- 4- yl)- 2- (hydroxymethyl)- N- methyl- 2- phenyl- 2,5- dihydro- 1H- pyrrole- 1- carboxamide
|1.||Drug Therapy (Chemotherapy)
|4.||Heterologous Transplantation (Xenotransplantation)