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Motor Neuron Disease (Primary Lateral Sclerosis)

Diseases characterized by a selective degeneration of the motor neurons of the spinal cord, brainstem, or motor cortex. Clinical subtypes are distinguished by the major site of degeneration. In AMYOTROPHIC LATERAL SCLEROSIS there is involvement of upper, lower, and brainstem motor neurons. In progressive muscular atrophy and related syndromes (see MUSCULAR ATROPHY, SPINAL) the motor neurons in the spinal cord are primarily affected. With progressive bulbar palsy (BULBAR PALSY, PROGRESSIVE), the initial degeneration occurs in the brainstem. In primary lateral sclerosis, the cortical neurons are affected in isolation. (Adams et al., Principles of Neurology, 6th ed, p1089)
Also Known As:
Primary Lateral Sclerosis; Motor System Disease; Motor Neuron Diseases; Lateral Sclerosis; Motor Neuron Disease, Familial; Anterior Horn Cell Disease; Lower Motor Neuron Disease; Motor Neuron Disease, Secondary; Secondary Motor Neuron Disease; Upper Motor Neuron Disease; Lateral Scleroses; Lateral Scleroses, Primary; Lateral Sclerosis, Primary; Motor System Diseases; Neuron Disease, Motor; Neuron Diseases, Motor; Primary Lateral Scleroses; Scleroses, Lateral; Scleroses, Primary Lateral; Sclerosis, Lateral; Sclerosis, Primary Lateral; Familial Motor Neuron Disease; Motor Neuron Disease, Lower; Motor Neuron Disease, Upper
Networked: 1823 relevant articles (57 outcomes, 170 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease)
2. Nervous System Diseases (Neurological Disorders)
3. Spinal Cord Injuries (Spinal Cord Injury)
4. Parkinson Disease (Parkinson's Disease)
5. Alzheimer Disease (Alzheimer's Disease)

Experts

1. Sobue, Gen: 37 articles (01/2020 - 03/2003)
2. Katsuno, Masahisa: 29 articles (01/2022 - 03/2003)
3. Tanaka, Fumiaki: 28 articles (07/2022 - 06/2004)
4. Adachi, Hiroaki: 19 articles (05/2016 - 03/2003)
5. Banno, Haruhiko: 16 articles (01/2020 - 03/2006)
6. Trojanowski, John Q: 15 articles (01/2019 - 09/2004)
7. Suzuki, Keisuke: 15 articles (11/2012 - 03/2006)
8. Brown, Robert H: 14 articles (01/2022 - 04/2003)
9. Shaw, Pamela J: 14 articles (01/2022 - 09/2003)
10. Lee, Virginia M-Y: 13 articles (01/2019 - 09/2004)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Motor Neuron Disease:
1. Proteins (Proteins, Gene)FDA Link
2. Biomarkers (Surrogate Marker)IBA
3. AntibodiesIBA
4. Ciliary Neurotrophic Factor (CNTF)IBA
5. RiluzoleFDA LinkGeneric
6. Amino AcidsFDA Link
7. CopperIBA
8. AMPA Receptors (AMPA Receptor)IBA
9. Brain-Derived Neurotrophic Factor (BDNF)IBA
10. GangliosidesIBA

Therapies and Procedures

1. Therapeutics
2. Denervation
3. Noninvasive Ventilation
4. Transplantation
5. Artificial Respiration (Mechanical Ventilation)