Sweet Syndrome (Acute Febrile Neutrophilic Dermatosis)

Condition characterized by large, rapidly extending, erythematous, tender plaques on the upper body usually accompanied by fever and dermal infiltration of neutrophilic leukocytes. It occurs mostly in middle-aged women, is often preceded by an upper respiratory infection, and clinically resembles ERYTHEMA MULTIFORME. Sweet syndrome is associated with LEUKEMIA.
Also Known As:
Acute Febrile Neutrophilic Dermatosis; Sweets Syndrome; Syndrome, Sweet; Syndrome, Sweet's; Dermatosis, Neutrophilic, Febrile, Acute; Neutrophilic Dermatosis, Acute Febrile; Sweet's Syndrome
Networked: 400 relevant articles (24 outcomes, 6 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Pyoderma Gangrenosum
2. Myelodysplastic Syndromes (Myelodysplastic Syndrome)
3. Inflammatory Bowel Diseases (Inflammatory Bowel Disease)
4. Skin Diseases
5. Vasculitis (Vasculitides)


1. Cohen, Philip R: 6 articles (04/2015 - 01/2002)
2. Fraga, Javier: 3 articles (05/2015 - 07/2005)
3. Cugno, M: 3 articles (10/2014 - 10/2010)
4. Fanoni, D: 3 articles (10/2014 - 10/2010)
5. Crosti, C: 3 articles (10/2014 - 10/2010)
6. Marzano, A V: 3 articles (10/2014 - 10/2010)
7. Callen, Jeffrey P: 3 articles (03/2012 - 03/2002)
8. Llamas-Velasco, Mar: 2 articles (05/2015 - 01/2013)
9. Bouaziz, Jean-David: 2 articles (01/2015 - 05/2014)
10. Mahajan, Vikram K: 2 articles (12/2014 - 06/2006)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Sweet Syndrome:
1. Adrenal Cortex Hormones (Corticosteroids)IBA
2. ColchicineFDA LinkGeneric
3. Azacitidine (5 Azacytidine)FDA Link
4. Interleukin 1 Receptor Antagonist Protein (Anakinra)FDA Link
5. SteroidsIBA
05/01/2004 - "In each patient, the skin lesions of Sweet's syndrome relapsed many times while they still had NTMI, and these lesions usually responded well to short courses of systemic steroids without any deterioration of NTMI."
06/01/1995 - "Use of systemic steroids is the treatment of choice for Sweet syndrome. "
03/01/2000 - "He had been treated with steroids for Sweet's syndrome for 2 years, and on September 17, 1998 presented with a cough and a fever of 38.9 degrees C. "
12/01/1995 - "Based on the presence of painful erythematous plaques on both hands and forearms, on the leukocytosis with excess bands in peripheral blood, on the histology showing dermal infiltration by mature granulocytes, and on the prompt response to steroids, the diagnosis was made of Sweet's syndrome associated with Crohn's disease. "
12/01/1990 - "Patients with the following diagnoses were presented: pyoderma gangraenosum in a patient with myelodysplastic syndrome passing into an acute myelomonocytic leukemia and specific cutaneous infiltration, primary genital infection with herpes simplex virus, type 1 (HSV-1) in an adult patient, pellagroid, Sweet's syndrome with follicular involvement, Sweet's syndrome in a patient with cancer of the breast, lichen amyloidosus, angiolymphoid hyperplasia with eosinophilia, Darier's disease 1. associated with basal cell carcinoma 2. with specific cutaneous infiltrations in a patient with acute myeloid leukemia, body building, anabolic steroids and fertility, multiple trichodiscomas and perifollicular fibromas, Buschke's scleroedema adultorum, extensive necrobiosis lipoidica without diabetes mellitus, extramammary, multifocal type of Paget's disease."
6. Potassium Iodide (Pima)FDA Link
7. Anti-Bacterial Agents (Antibiotics)IBA
8. Indomethacin (Indometacin)FDA LinkGeneric
9. MethylprednisoloneFDA LinkGeneric
10. Doxycycline (Vibramycin)FDA LinkGeneric

Therapies and Procedures

1. Drug Therapy (Chemotherapy)
2. Remission Induction
3. Off-Label Use
4. Plasmapheresis
5. Phototherapy (Light Therapy)