Prosthesis-Related Infections

Infections resulting from the implantation of prosthetic devices. The infections may be acquired from intraoperative contamination (early) or hematogenously acquired from other sites (late).

Also Known As:

Infections, Prosthesis-Related; Infection, Prosthesis Related; Prosthesis Related Infections; Related Infection, Prosthesis; Related Infections, Prosthesis; Prosthesis Related Infection; Prosthesis-Related Infection

Networked: 34 relevant articles (2 outcomes, 5 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Surgical Wound Infection
2.	Bacteremia
3.	Neoplasms (Cancer)

Experts

1.	Feng, Wenjun: 2 articles (01/2021 - 02/2020)
2.	Li, Jie: 2 articles (01/2021 - 02/2020)
3.	Sun, Xiaobo: 2 articles (01/2021 - 02/2020)
4.	Zeng, Jianchun: 2 articles (01/2021 - 02/2020)
5.	Zeng, Yirong: 2 articles (01/2021 - 02/2020)
6.	Zeng, Yuqing: 2 articles (01/2021 - 02/2020)
7.	Zhu, Xingyang: 2 articles (01/2021 - 02/2020)
8.	Chokr, Ali: 2 articles (02/2013 - 12/2007)
9.	Leterme, Damien: 2 articles (02/2013 - 12/2007)
10.	Sadovskaya, Irina: 2 articles (02/2013 - 12/2007)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Prosthesis-Related Infections:

1.	Vancomycin FDA LinkGeneric 07/01/2007 - "This study suggested that CWU could effectively enhance vancomycin release and antimicrobial efficacy of ALBC, which may be of clinical significance for treating prosthesis-related infections." 06/01/2009 - "Bone tissue and plasma concentrations of linezolid and vancomycin in rabbits with prosthesis-related infection due to MRSA."
2.	SilverIBA 05/01/2022 - "In this study, our aim was to analyze the efficacy of silver-coated megaprostheses in reducing the risk of prosthesis-related infection. " 05/01/2022 - "Implantation of a silver-coated mega-prosthesis in non-oncological patients did not significantly reduce the risk of prosthesis-related infection."
3.	Anti-Bacterial Agents (Antibiotics)IBA 05/21/2022 - "Because of its profile and high bioavailability, it is commonly used as part of an oral multimodal alternative for prolonged parenteral antibiotic regimens, e.g., to treat bone and joint or prosthesis-related infections. " 12/01/2006 - "Application of ultrasound in combination with antibiotic release in clinical practice could therefore lead to better prevention or treatment of prosthesis-related infections." 09/01/1994 - "To evaluate the adequacy of penetration of antibiotics into biofilm, a novel in vitro model for prosthesis-related infection was developed. " 01/01/1990 - "Clean-air systems in combination with perioperative systemic antibiotics reduce prosthesis-related infections from 3 or 4 per cent to a few per thousand. " 06/07/2013 - "Prosthesis-related infection is a serious complication for patients after orthopedic joint replacement, which is currently difficult to treat with antibiotic therapy. "
4.	Bone Cements (Bone Glue)IBA 03/01/2013 - "Drug-loaded bone cement is used as an application method to prevent and treat prosthesis-related infection. " 12/01/2006 - "The objective of this study was to investigate whether the viability of bacteria derived from patients with a prosthesis-related infection could be further decreased when antibiotic release from bone cements was combined with application of pulsed ultrasound. " 11/01/2008 - "The use of antibiotic loaded bone cements (ALBCs) has become a common clinical practice in the prevention and treatment of prosthesis-related infections. " 02/01/2004 - "This review presents the backgrounds of bone cements, prosthesis-related infection and antibiotic-loaded bone cements. " 02/01/2004 - "Backgrounds of antibiotic-loaded bone cement and prosthesis-related infection."
5.	Linezolid (Zyvox)FDA Link 01/05/2020 - "In this study, it was aimed to formulate linezolid loaded electrospun PLGA and PCL fiber mats doing controlled drug release, to be used in the treatment and prophylaxis of the prosthesis related infections. " 06/01/2009 - "Bone tissue and plasma concentrations of linezolid and vancomycin in rabbits with prosthesis-related infection due to MRSA." 02/23/2023 - "The Antimicrobial Activity of Micron-Thin Sol-Gel Films Loaded with Linezolid and Cefoxitin for Local Prevention of Orthopedic Prosthesis-Related Infections."
6.	AntigensIBA 12/01/2007 - "In conclusion, the encouraging results obtained in the animal study could not be readily applied for the diagnosis of staphylococcal orthopedic-prosthesis-related infections in humans, and PNAG does not seem to be an appropriate antigen for this purpose. " 12/01/2007 - "Potential use of poly-N-acetyl-beta-(1,6)-glucosamine as an antigen for diagnosis of staphylococcal orthopedic-prosthesis-related infections."
7.	methylallyl trisulfide (MATS)IBA 01/05/2020 - "In this study, it was aimed to formulate linezolid loaded electrospun PLGA and PCL fiber mats doing controlled drug release, to be used in the treatment and prophylaxis of the prosthesis related infections. "
8.	Rifampin (Rifampicin)FDA LinkGeneric 02/01/2000 - "Although numerous antimicrobial-coated surfaces have been suggested to guard against prosthesis-related infection, only a few, such as minocylcine plus rifampin, are clinically protective. " 12/01/1997 - "The early results with quinolones and rifampin for prosthesis-related infection are encouraging. "
9.	Virulence Factors (Pathogenicity Factors)IBA 12/15/2000 - "These differences in mode of prosthesis-related infection are explained by differences in virulence factors."
10.	Polymethyl Methacrylate (Sol)IBA 02/23/2023 - "The Antimicrobial Activity of Micron-Thin Sol-Gel Films Loaded with Linezolid and Cefoxitin for Local Prevention of Orthopedic Prosthesis-Related Infections."

Therapies and Procedures

1.	Prostheses and Implants (Prosthesis) 11/01/2016 - "When a prosthesis-related infection or erosion occurs, treatment consists in the surgical removal of the prosthesis by laparoscopy/and/or a transanal procedure. " 11/01/2016 - "Five patients from the PE prosthesis group (3.3 %), compared with two patients from the PP prosthesis group (1.1 %), experienced prosthesis-related infection or erosion (p = 0.16). " 11/01/2020 - "Failure was defined by death due to prosthesis-related infection, need for prosthesis removal in case of conservative treatment, or recurrence of infectious signs on a new prosthesis. " 05/01/2022 - "Implantation of a silver-coated mega-prosthesis in non-oncological patients did not significantly reduce the risk of prosthesis-related infection." 07/01/2005 - "We suggest that the antibiotic locally delivered from the prosthesis coating might be an effective supplement for prevention of prosthesis-related infection in penile prosthesis surgery."
2.	Therapeutics 01/01/2020 - "The altered flora, in individuals immunocompromised from cancer therapy, increases their risk of prosthesis-related infections. " 06/07/2013 - "Prosthesis-related infection is a serious complication for patients after orthopedic joint replacement, which is currently difficult to treat with antibiotic therapy. "
3.	Arthroplasty 02/19/2020 - "Can nasal Staphylococcus aureus screening and decolonization prior to elective total joint arthroplasty reduce surgical site and prosthesis-related infections? " 01/01/2019 - "Search terms such as surgical gloves, surgical site infections, prosthesis-related infections, arthroplasty were used, including Medical Subject Headings terms. "
4.	Replacement Arthroplasty 06/07/2013 - "Prosthesis-related infection is a serious complication for patients after orthopedic joint replacement, which is currently difficult to treat with antibiotic therapy. "
5.	Orthopedic Procedures 08/01/2023 - "Background: Prosthesis-related infections (PRIs) and surgical site infections (SSIs) remain one of the most devastating complications among patients undergoing clean orthopedic surgeries. "