Islets of Langerhans Transplantation

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356 relevant articles (28 outcomes, 25 trials/studies) found for this Therapy

Description: The transference of pancreatic islets within an individual, between individuals of the same species, or between individuals of different species.

Also Known As:

Islands of Langerhans Transplantation; Islands of Pancreas Transplantation; Islet Transplantation; Transplantation, Islands of Langerhans; Transplantation, Islands of Pancreas; Transplantation, Islet; Islet Transplantations; Islets Transplantation, Pancreatic; Transplantations, Islet; Grafting, Islets of Langerhans; Pancreatic Islets Transplantation; Transplantation, Islets of Langerhans; Transplantation, Pancreatic Islets

Relationship Network

Therapy Context: Research Results

Operative Surgical Procedures: 4

Transplantation: 36585

Cell Transplantation: 1172

Islets of Langerhans Transplantation: 356

Endocrine Surgical Procedures: 1

Islets of Langerhans Transplantation: 356

Experts

1.	Shapiro, A M James: 7 articles (01/2006 - 01/2004)
2.	Ryan, Edmond A: 5 articles (06/2006 - 02/2004)
3.	Maffi, Paola: 4 articles (05/2008 - 04/2003)
4.	Secchi, Antonio: 4 articles (05/2008 - 04/2003)
5.	Bertuzzi, Federico: 3 articles (05/2008 - 04/2003)
6.	Fiorina, Paolo: 3 articles (12/2007 - 04/2003)
7.	Brendel, M D: 3 articles (04/2006 - 08/2002)
8.	Bretzel, R G: 3 articles (04/2006 - 08/2002)
9.	Sutherland, D E R: 3 articles (03/2006 - 08/2003)
10.	Paty, Breay W: 3 articles (09/2005 - 04/2004)

Related Diseases

1.	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 08/01/2005 - "Improved human pancreatic islet isolation for a prospective cohort study of islet transplantation vs best medical therapy in type 1 diabetes mellitus." 08/01/1994 - "The therapeutical efficacy of islet transplantation in treating insulin-dependent diabetes mellitus (IDDM) patients is marked for a short time and the long-term efficacy is unsatisfactory" 03/27/1999 - "The findings have potential implications for islet transplantation as well as improved and more cost-effective therapy for IDDM." 02/01/2008 - "We conclude that in islet transplantation and autoimmune diabetes, ICOS blockade can be effective in inhibiting alloimmunity and preventing autoimmunity but is ineffective in inhibiting recurrence of autoimmunity." 04/27/1994 - "Islet transplantation can provide a therapeutic option for patients who suffer from type 1 diabetes mellitus, especially if current aggressive immunosuppression could be eliminated" Get all the results and reference details, order at left...
2.	Hypoglycemia (Reactive Hypoglycemia) 03/01/2007 - "OBJECTIVE: The objective of the study was to determine whether the avoidance of hypoglycemia achieved through islet transplantation results in improved glycemic thresholds for counterregulatory responses" 07/01/2003 - "Careful assessment of the safety and efficacy of islet transplantation should guide the selection process of a small number of children with type 1 diabetes who may be eligible for the procedure--some of whom are already receiving immunosuppression because of a previous transplant, others who are scheduled to receive de novo islet alone transplantation because of a life threatening risk of hypoglycemia" 11/01/2008 - "OBJECTIVE: To determine the impact of islet transplantation (ITx) on hypoglycemia awareness in patients with unstable type 1 diabetes and its relation to islet function" 11/01/2008 - "Restoration of hypoglycemia awareness after islet transplantation." 03/01/2007 - "Islet transplantation can ameliorate occurrences of hypoglycemia in these patients" Get all the results and reference details, order at left...
3.	Diabetes Mellitus 05/29/2001 - "It is obvious that the achievement of immunological tolerance would broaden the indication for islet transplantation to a much larger cohort of patients with type I diabetes mellitus, most likely preventing long-term complications and contributing to a much improved quality of life" 01/01/1999 - "Islet transplantation is a potential cure for diabetes mellitus" 01/01/1998 - "Islet transplantation is a potential cure for diabetes mellitus" 08/27/2004 - "Intrahepatic human islet transplantation has raised hopes for a cure for diabetes mellitus, especially in patients with type 1 diabetes; however, the need for a substantial amount of islets and, in many instances, repeated transplantations demonstrates underlying problems with this procedure, such as failure of angiogenesis and immunologic rejection" 05/29/2001 - "Islet transplantation holds renewed promise as a cure for type I diabetes mellitus" Get all the results and reference details, order at left...
4.	Hyperglycemia 01/01/1992 - "Thus, by preventing hyperglycemia at the time of islet transplantation, the long-term result of islet transplantation was improved" 07/25/2006 - "Control studies revealed that both intrahepatic islet transplantation and hyperglycemia altered the biodistribution kinetics of the PET probe systemically" 09/01/2007 - "In addition, we studied whether the transplantation of pure beta-cells, in volumes similar to that used in islet transplantation, would suffice to reverse hyperglycemia in diabetic mice" 04/01/1998 - "In contrast to high-number islet transplantation, which restored normoglycemia in 25 control animals, the low-number islet transplantation was followed by persisting hyperglycemia for at least 13 months" 01/01/1995 - "It is supposed that two different types of proliferative stimuli were active in this model of low number islet transplantation: 1) The chronic hyperglycemia induces endocrine epithelial cell proliferation in the grafts" Get all the results and reference details, order at left...
5.	Inflammation 08/01/2008 - "To optimize islet transplantation for diabetes reversal, we suggest that targeting these interacting barriers and the accompanying inflammation may represent an improved approach to achieve successful clinical islet transplantation by enhancing islet survival, regeneration or neogenesis potential, and tolerance induction" 10/01/2008 - "CONCLUSION: These results suggested that preoperative GLN administration induced HSP70 and GSH expressions before islet transplantation, thus attenuating IL-1beta-induced injury in association with NO production and apoptosis, which might be potential tool to mitigate the ischemic damage to islet cells and the early inflammation at the site of implantation through a self-protective mechanism." 08/01/2008 - "Resolving the conundrum of islet transplantation by linking metabolic dysregulation, inflammation, and immune regulation." 11/01/2006 - "Culture conditions can modulate the proinflammatory state of islets, and could be used in clinical islet transplantation to reduce inflammation during engraftment." 02/27/2006 - "CONCLUSIONS: Based on the novel development of immortalized islet endothelium, these results suggest that PAF may have a dual role that links inflammation to angiogenesis in the early events of islet transplantation." Get all the results and reference details, order at left...
80 Diseases and 356 more articles analyzed in the Research Interface, order at left...

Related Drugs and Biologics

1.	Insulin (Novolin)
2.	Blood Glucose (Blood Sugar)
3.	Glycosylated Hemoglobin A (Glycosylated Hemoglobin)
4.	Streptozocin (Streptozotocin)
5.	Glucose (Dextrose)
6.	Cytokines
7.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
8.	Heme Oxygenase-1
9.	Cyclosporine (Ciclosporin)
10.	Sucrose (Saccharose)
65 Drugs and Important Bio-Agents and 121 more articles analyzed in the Research Interface, order at left...

Related Therapies and Procedures

1.	Transplantation (Transplant Recipients)
2.	Homologous Transplantation (Allograft)
3.	Autologous Transplantation (Autograft)
4.	Transplants (Transplant)
5.	Liver Transplantation
16 Therapies and Procedures and 76 more articles analyzed in the Research Interface, order at left...

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