|1.||Tanaka, Yuetsu: 7 articles (04/2014 - 01/2006)|
|2.||Mesnard, Jean-Michel: 6 articles (06/2012 - 10/2003)|
|3.||Fujii, Masahiro: 5 articles (03/2013 - 03/2002)|
|4.||Higuchi, Masaya: 5 articles (03/2013 - 03/2002)|
|5.||Zhang, Jing: 5 articles (11/2011 - 12/2007)|
|6.||Hattori, Toshio: 5 articles (11/2011 - 12/2007)|
|7.||Yamada, Osamu: 4 articles (05/2011 - 12/2007)|
|8.||Aboud, Mordechai: 4 articles (07/2008 - 01/2004)|
|9.||Oie, Masayasu: 4 articles (01/2006 - 03/2002)|
|10.||Cartier, Luis: 3 articles (04/2014 - 10/2005)|
|1.||T-Cell Leukemia (Leukemia, T Cell)
06/01/2002 - "Recent studies suggest that the human T-cell leukemia virus type 1 (HTLV-1) Tax protein induces oxidative stress and apoptotic T-cell death. "
04/01/1995 - "There is a high degree of intraisolate sequence heterogeneity in the tax gene of human T-cell leukemia virus type I (HTLV-I), although the sequence variation between patients is small compared with that of human immunodeficiency virus type 1. In the present study, we investigated whether naturally occurring amino acid substitutions changed the properties of the Tax protein in two respects: first, recognition of the protein by cytotoxic T lymphocytes (CTL), and second, the ability of the Tax protein to transactivate various promoters. "
12/01/1992 - "The present study demonstrates that the tax gene product of human T-cell leukemia virus type I trans activates the major enhancer of HCMV more than 60-fold in the T-cell line Jurkat. "
12/01/2015 - "Here, we show that HIC and I-mfa directly interact with human T-cell leukemia virus type-1 (HTLV-1) Tax protein in vitro. "
09/01/2014 - "Whether NF-κB promoter transactivation by the human T-cell leukemia virus type 1 (HTLV-1) Tax protein requires Tax SUMOylation is still a matter of debate. "
01/01/2012 - "Prior studies have focused chiefly on the CTL response to the immunodominant Tax protein: efficient lysis of Tax-expressing cells inversely correlates with proviral load in nonmalignant infection. "
04/01/2014 - "Axonal degeneration in HAM/TSP patients occurs without neuron infection, with the secreted viral Tax protein proposed to be involved. "
12/01/2013 - "In contrast, intracellular levels of Gag, Env, or Tax protein are affected by IFN-α treatment in T cells, primary lymphocytes, or 293T cells transfected with HTLV-1 or HTLV-2 molecular clones, demonstrating that IFN-α acts during the late stages of infection. "
01/01/2005 - "The BLGFP, H1GFP and H2GFP cell lines detect virus infection by the expression of GFP via the transactivation of the LTR via the Tax protein of BLV, HTLV-1 or HTLV-2, respectively. "
10/01/2004 - "Differences between the biological activities of the respective tax gene products (Tax1 and Tax2) may be one factor which accounts for the differential pathogenicities associated with infection. "
|3.||Sjogren's Syndrome (Sjogren Syndrome)
10/01/2005 - "Only in patients with HAM/TSP and Sicca syndrome, the presence of Tax protein was observed in CD-4 and CD-8 lymphocytes and in glandular acini. "
10/01/2005 - "[Viral Tax protein expression in salivary glands of patients infected with human t-cell lymphotropic virus type I and Sicca Syndrome]."
10/01/2005 - "The immunohistochemical study of CD-4, CD-8 and CD45 lymphocytes, metalloproteinase MMP-9 and viral Tax protein in pathological samples of salivary glands may help to differentiate primary from viral Sicca syndrome. "
08/15/2001 - "The Tax protein of this virus is thought to contribute to cellular transformation and tumor development. "
11/09/2007 - "In this regard, the oncogenic potential of the human T cell leukemia virus type 1 Tax protein correlates with its binding capacity to the tumor suppressor hDlg. "
11/09/2007 - "The PDZ domain-binding motif of the human T cell leukemia virus type 1 tax protein induces mislocalization of the tumor suppressor hScrib in T cells."
01/01/2006 - "Inactivation of tumor suppressor Dlg1 augments transformation of a T-cell line induced by human T-cell leukemia virus type 1 Tax protein."
09/01/2008 - "Previous studies have demonstrated that the HTLV-1-encoded Tax protein inhibits the function of tumor suppressor p53 through a Tax-induced NF-kappaB pathway. "
03/01/2000 - "However, patients with the cutaneous T-cell lymphoma mycosis fungoides (MF) are HTLV-1 and -2 seronegative yet harbor proviral sequences identical to those that encode the HTLV-1 transactivating and transforming gene product p40tax in their peripheral blood mononuclear cells (PBMCs), and they usually have antibodies to p40(tax). "
11/01/1998 - "As a consequence of studies of patients with mycosis fungoides and some of their healthy relatives who are antibody negative but were found to carry the tax sequence of HTLV-1 in their lymphocytes and who had antibodies to the p40(tax) protein, a study was undertaken to determine the prevalence of the "tax-only" state in 250 healthy blood donors and other volunteers. "
|1.||Matrix Metalloproteinase 9 (Gelatinase B)
|3.||B-Lymphocyte Epitopes (B-Cell Epitope)
|5.||NF-kappa B (NF-kB)
|7.||DNA (Deoxyribonucleic Acid)
|8.||I-kappa B Proteins (I kappa B)
|9.||NF-kappaB inhibitor alpha
|10.||Casein Kinase II (Casein Kinase 2)