|1.||Taira, Kazunari: 9 articles (10/2005 - 01/2002)|
|2.||Kawasaki, Hiroaki: 8 articles (09/2004 - 01/2002)|
|3.||Lewin, Alfred S: 7 articles (01/2016 - 09/2003)|
|4.||Suyama, Eigo: 6 articles (09/2004 - 01/2003)|
|5.||Czubayko, F: 5 articles (02/2005 - 09/2000)|
|6.||Lee, Seong-Wook: 4 articles (01/2015 - 01/2008)|
|7.||Jeong, Jin-Sook: 4 articles (01/2015 - 12/2007)|
|8.||Liu, Fenyong: 4 articles (02/2011 - 08/2002)|
|9.||Wadhwa, Renu: 4 articles (10/2005 - 06/2003)|
|10.||Kaul, Sunil C: 4 articles (10/2005 - 06/2003)|
12/01/2002 - "Anti-HIV-1 tat-rev and env ribozymes and Rev aptamers were previously demonstrated to provide relatively long-term protection against HIV-1 infection in vitro. "
02/24/2000 - "Ribozymes can be designed to cleave target RNA sequences specifically and show promise for the treatment of HBV infection. "
04/20/2010 - "To our knowledge, this study showed for the first time that ribozymes expressed following targeted gene transfer with Salmonella-based vectors are highly active and specific in blocking viral infection. "
08/01/2008 - "This study suggests that ribozymes targeting essential genes of the late kinetic class may represent a new therapeutic strategy for inhibiting HSV infection."
03/01/2006 - "In the present study, we demonstrate using ribozymes that a depletion of CXCR4 and CCR5 mRNAs can be achieved simultaneously in human PBMCs (peripheral blood mononuclear cells), cells commonly used by the virus for infection and replication. "
07/01/1999 - "PKC alpha ribozymes may prove useful in the management of malignant gliomas."
01/01/2002 - "In vivo targeting of SF/HGF and c-met expression via U1snRNA/ribozymes inhibits glioma growth and angiogenesis and promotes apoptosis."
07/01/1999 - "Taken together, our data suggest that the PKC alpha ribozymes are a potent inducer of apoptosis in glioma cells, which may act through suppressing Bcl-xL gene expression and/or activity. "
12/01/1995 - "Further, following transient transfection of one of these ribozymes into the SNB-19 glioma cell line, significant in vivo cleavage activity against cellular CD44 transcripts was demonstrated by flow cytometrical analysis. "
06/15/2005 - "The effects of U1/ribozymes +/- gamma-radiation on glioma cell proliferation, apoptosis, xenograft growth, and animal survival were examined. "
|3.||Hepatocellular Carcinoma (Hepatoma)
01/01/1999 - "Ribozymes were effective in inhibiting alpha 1AT expression in a human hepatoma cell line using a newly developed simian virus (SV40) vector system. "
10/01/2002 - "Reversal of drug resistance of hepatocellular carcinoma cells by adenoviral delivery of anti-MDR1 ribozymes."
07/01/1999 - "A combinatorial screening method has been used to identify hairpin ribozymes that inhibit hepatitis B virus (HBV) replication in transfected human hepatocellular carcinoma (HCC) cells. "
11/01/1996 - "Furthermore, transduction of human hepatoma cells, HepG2, with retroviral vectors carrying CR2 or CR4 ribozymes enabled the cells to resist the infection by retroviral particles containing HCV target sequences. "
03/01/2002 - "Resistance genes coding for inhibitors of hepadnaviral replication, such as ribozymes, antisense RNA, and dominant negative mutants have been shown to be effective in transfected hepatoma cells. "
06/01/2002 - "In addition, in vivo mice studies demonstrated marked tumor growth suppression by the Bradeion-specific ribozymes. "
01/01/2000 - "Mutated H-ras, fos, and erb-B2 genes have been chosen as targets for ribozymes in previous studies, and antitumor efficacy has been demonstrated by reversion of the malignant phenotypes and by inhibition of tumor growth both in vitro and in vivo. "
08/01/1998 - "These studies support the use of ErbB-4 ribozymes to define the role of ErbB-4 receptors in human cancers."
12/01/1996 - "Most of the studies performed to date have described the use of ribozymes as therapeutic agents for viral and cancer diseases. "
10/07/1994 - "This study suggests the possible utility of anti-oncogene ribozymes as suppressors of tumor cell growth as well as inhibitors of cellular transformation."
12/31/2007 - "In this study, we evaluated in vivo function of the hTERT-targeting trans-splicing ribozymes by employing the molecular analysis of expression level of genes affected by the ribozyme delivery into peritoneal carcinomatosis mice model. "
05/29/2009 - "The introduction of ribozymes targeting the FAPP2 gene in colon carcinoma cells induced their apoptosis in the presence of Fas agonistic antibody. "
10/01/1997 - "To assess the significance of FGF-BP expression in tumors, we depleted human SCC (ME-180) and colon carcinoma (LS174T) cell lines of their endogenous FGF-BP by targeting with specific ribozymes. "
07/01/1999 - "Specific ribozymes might be useful in the treatment of pancreatic carcinomas containing an oncogenic GTT mutation in codon 12 of the Ki-ras gene."
01/01/1992 - "In this study a ribozyme (catalytic RNA) was designed to site specifically cleave the mRNA of the activated H-ras gene expressed in human bladder carcinoma EJ cells. "
|1.||RNA (Ribonucleic Acid)
|2.||Messenger RNA (mRNA)
|3.||Small Interfering RNA (siRNA)
|5.||Interleukin-10 (Interleukin 10)
|8.||Antisense RNA (Anti-Sense RNA)
|9.||Transforming Growth Factor beta (TGF-beta)
|3.||Heterologous Transplantation (Xenotransplantation)
|5.||Drug Therapy (Chemotherapy)