|1.||Xie, Keping: 9 articles (07/2008 - 12/2003)|
|2.||Wei, Daoyan: 9 articles (07/2008 - 12/2003)|
|3.||Wang, Liwei: 8 articles (07/2008 - 12/2003)|
|4.||Yao, James: 7 articles (07/2008 - 12/2003)|
|5.||Zhang, Jun: 6 articles (01/2013 - 04/2005)|
|6.||Knappskog, Stian: 5 articles (09/2014 - 02/2011)|
|7.||Lønning, Per E: 5 articles (09/2014 - 02/2011)|
|8.||Ajani, Jaffer: 5 articles (02/2007 - 12/2003)|
|9.||Hveem, Kristian: 4 articles (09/2014 - 02/2011)|
|10.||Vatten, Lars: 4 articles (09/2014 - 02/2011)|
01/01/2014 - "Transcription factor Sp1 is multifaceted, with the ability to function as an oncogene or a tumor suppressor, depending on the cellular context. "
12/01/2012 - "We found that the tumor-associated factor TGF-β may selectively upregulate the expression of miR-27a via the SP1 transcription factor. "
09/21/2012 - "Prostaglandin E(2) produced by the tumor cell plays a critical role in up-regulating SERCA3 by enhancing the binding of its transcription factor Sp1. "
09/01/2012 - "The MDM2 promoter polymorphism (SNP309T > G) extends a binding site for the transcription factor Sp1 and has been linked to elevated cancer risk and/or young age at cancer diagnosis, especially in females. "
01/01/2012 - "One of these polymorphisms (SNP309T>G; rs2279744) facilitates Sp1 transcription factor binding to the promoter and is associated with increased cancer risk. "
12/15/2012 - "In summary, these findings reveal that miR-34c-5p directly regulates sGCβ1 expression, and they identify the key transcription factor Sp1 that governs miR-34c-5p expression during hypoxia."
01/01/2009 - "Expression of the Sp1 transcription factor is induced by hypoxia, and the ADAM17 promoter contains predicted Sp1 binding sites. "
07/01/2005 - "In particular, the constitutively bound transcription factor Sp1 serves as a molecular switch by recruiting HIF-1alpha in hypoxia to displace the transcription activator Myc from the promoter. "
01/01/2015 - "In this study, we investigated whether HIFs and transcription factor Sp1 cooperate to activate multiple genes in CCC cells under conditions of serum starvation and hypoxia (SSH) and then contribute to malignant phenotypes. "
01/01/2009 - "In this study, we investigated whether Sp1 transcription factor induces ADAM17 and/or contributes to tumor cell invasiveness in hypoxia. "
|3.||Pancreatic Neoplasms (Pancreatic Cancer)
07/25/2012 - "In conclusion, our study characterized for the first time the human NME5 promoter which is controlled by Sp1 transcription factor in pancreatic cancer."
12/15/2007 - "Human pancreatic cancer over expresses the transcription factor Sp1. "
02/15/2007 - "In this study, we have analyzed the role of the transcription factor Sp1 in TGF-beta-induced and Smad-mediated gene regulation during epithelial to mesenchymal transition (EMT) and migration of pancreatic cancer cells. "
11/22/2013 - "Triptolide-induced cell death in pancreatic cancer is mediated by O-GlcNAc modification of transcription factor Sp1."
03/01/2008 - "Upregulation of miRNA-22 expression by curcumin or by transfection with miRNA-22 mimetics in the PxBC-3 pancreatic cancer cell line suppressed expression of its target genes SP1 transcription factor (SP1) and estrogen receptor 1 (ESR1), while inhibiting miRNA-22 with antisense enhanced SP1 and ESR1 expression. "
|4.||Stomach Neoplasms (Stomach Cancer)
01/01/2005 - "Our recent study has shown that transcription factor Sp1 is an independent prognostic factor in gastric cancer. "
04/02/2014 - "MiR-145, miR-133a and miR-133b inhibit proliferation, migration, invasion and cell cycle progression via targeting transcription factor Sp1 in gastric cancer."
06/01/2013 - "miR-22 is down-regulated in gastric cancer, and its overexpression inhibits cell migration and invasion via targeting transcription factor Sp1."
01/01/2013 - "MTA2 expression was positively correlated with transcription factor Sp1 in gastric cancer tissues (r = 0.326, P < 0.001). "
07/01/2008 - "Overexpression of the transcription factor Sp1 may play a critical role in human gastric cancer angiogenesis. "
03/15/2000 - "In this study, we have simultaneously determined the level of uPAR and the activity of the transcription factor Sp1 in 14 breast carcinomas and 5 benign lesions. "
05/01/1994 - "This promoter region includes one of the regulatory elements footprinted by the purified Sp1 transcription factor and mediates the majority of the transcriptional activity from the HPFKM p2 promoter in the human cervical carcinoma cell line HeLa S3. "
01/01/2015 - "We previously demonstrated that a physical interaction between the ubiquitously expressed transcription factor Sp1 and HIF2 is a major cause of FVII gene activation in poor prognostic ovarian clear cell carcinoma (CCC) cells under hypoxia. "
01/01/2010 - "Brg-1 mediates the constitutive and fenretinide-induced expression of SPARC in mammary carcinoma cells via its interaction with transcription factor Sp1."
12/30/1992 - "The expression of the transcription factor Sp1 and EGF receptor (EGFR) was examined on human gastric carcinoma cell lines and gastric carcinoma tissues as well as corresponding normal mucosa in order to clarify the mechanism of overexpression of EGFR gene without gene amplification. "
|1.||Transcription Factors (Transcription Factor)
|2.||Transforming Growth Factor beta (TGF-beta)
|3.||Epidermal Growth Factor Receptor (EGF Receptor)
|4.||NF-kappa B (NF-kB)
|5.||RNA (Ribonucleic Acid)
|9.||Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
|10.||Collagen Type I (Type I Collagen)
|1.||Heterologous Transplantation (Xenotransplantation)
|2.||Drug Therapy (Chemotherapy)