Quisqualic Acid

An agonist at two subsets of excitatory amino acid receptors, ionotropic receptors that directly control membrane channels and metabotropic receptors that indirectly mediate calcium mobilization from intracellular stores. The compound is obtained from the seeds and fruit of Quisqualis chinensis.

Also Known As:

Networked: 127 relevant articles (3 outcomes, 13 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Brewer, K L: 6 articles (01/2004 - 01/2000)
2.	Brewer, Kori L: 5 articles (07/2009 - 02/2004)
3.	Abraham, K E: 5 articles (01/2004 - 01/2000)
4.	Tu, Jian: 3 articles (01/2015 - 06/2003)
5.	Lee, Jeung Woon: 3 articles (01/2012 - 07/2008)
6.	Eaton, Mary J: 3 articles (01/2009 - 01/2007)
7.	Yezierski, Robert P: 3 articles (11/2008 - 04/2003)
8.	McGinty, J F: 3 articles (02/2001 - 01/2000)
9.	Furmanski, Orion: 2 articles (01/2012 - 07/2008)
10.	Sagen, Jacqueline: 2 articles (01/2012 - 07/2008)

Related Diseases

1.	Seizures (Absence Seizure) 07/01/1994 - "Quisqualic acid-induced seizures during development: a behavioral and EEG study." 10/01/1987 - "The present studies demonstrated that the microinjection of quisqualic acid (QA) into unilateral amygdala in chronically implanted cats resulted in various types of limbic seizures in accordance with injected doses. " 01/01/1986 - "GDEE given by intraperitoneal blocked quisqualate-induced seizures dose-dependently. " 01/01/1986 - "To better characterize the role of the quisqualate-sensitive receptor in the generation of seizures, quisqualate was administered to mice by intracerebroventricular (ICV) route and immediate onset generalized seizures were observed. " 08/16/1985 - "Quisqualic acid-induced hippocampal seizures in unanesthetized cats."
2.	Pain (Aches) 01/01/2006 - "The pain model used unilateral intraspinal injection of quisqualic acid (QUIS) into the dorsal horn between vertebral levels T13 and L1. " 01/01/2004 - "Using the quisqualic acid model of spinal cord injury, we examined the extent of gray matter damage and onset of injury-induced pain behaviors at various time points following injury in wild-type vs. IL-10((-/-)) mice. " 01/01/2001 - "AIDA, but not NBQX, significantly reduced the frequency of, and delayed the onset of, quisqualic acid-induced spontaneous pain-related behavior. " 02/01/2015 - "We assessed the effects of intraplantar quisqualate, a non-selective glutamate receptor agonist, on heat and mechanical pain behaviours in mice. " 11/01/2011 - "This study was designed to evaluate morphological changes in the dorsal horn of the spinal cord and assess profiles of pain behaviors following intraspinal injection of N-methyl-D-aspartate (NMDA) or quisqualate (QUIS) in rats. "
3.	Spinal Cord Injuries (Spinal Cord Injury) 07/01/2009 - "Spinal cord injury was induced by unilateral microinjections of quisqualic acid at spinal levels T12-L2. " 11/01/2008 - "Injecting quisqualate (QUIS) into the rat spinal cord models spinal cord injury (SCI) and causes at-level scratching and self-injury. " 07/06/1998 - "Previous studies have shown that intraspinal injection of quisqualic acid (QUIS) produces excitotoxic injury with pathological characteristics similar to those associated with ischemic and traumatic spinal cord injury (SCI). " 03/01/2001 - "Intraspinal injection of quisqualic acid (QUIS) produces excitotoxic injury with pathophysiological characteristics similar to those associated with ischemic and traumatic spinal cord injury (SCI). " 01/01/2000 - "Intraspinal injection of quisqualic acid produces an excitotoxic injury with pathological characteristics similar to those associated with ischemic and traumatic spinal cord injury. "
4.	Alzheimer Disease (Alzheimer's Disease) 12/01/1990 - "This strongly suggests that quisqualate lesions of the NBM are not sufficient to produce severe and lasting mnemonic disorders resembling those seen in Alzheimer's disease (AD). " 12/01/1990 - "Quisqualate (AMPA) receptor binding was markedly reduced in the molecular layer of the cerebellum from patients with Alzheimer's disease (167 +/- 13 pmoles/gm) compared with control patients (280 +/- 13 pmoles/gm). " 04/01/1990 - "Binding was decreased significantly for all ligands except quisqualate in stratum pyramidale of CA1 of the Alzheimer's disease brains. " 01/01/1990 - "The number of binding sites was then determined in parallel with choline acetyltransferase activity in the temporal cortex of patients with Alzheimer's disease, demented and non-demented patients with Parkinson's disease, and in the cerebral cortex of rats with quisqualic acid lesions of the nucleus basalis magnocellularis. " 01/01/1990 - "Alzheimer's disease: changes in hippocampal N-methyl-D-aspartate, quisqualate, neurotensin, adenosine, benzodiazepine, serotonin and opioid receptors--an autoradiographic study."
5.	Olivopontocerebellar Atrophies (Olivopontocerebellar Atrophy) 07/23/1990 - "We used receptor autoradiography to study the distribution of ionotropic and metabotropic quisqualate (QA) receptors in normal human cerebellar cortex and cerebellar cortex from 7 cases of olivopontocerebellar atrophy (OPCA). "

Related Drugs and Biologics

1.	N-Methylaspartate (NMDA)
2.	2,3- dioxo- 6- nitro- 7- sulfamoylbenzo(f)quinoxaline (NBQX)
3.	Picrotoxin
4.	Bicuculline
5.	F 721
6.	Kainic Acid (Kainate)
7.	Aspartic Acid (Aspartate)
8.	Opioid Peptides (Opioid Peptide)
9.	Glutamic Acid (Glutamate)
10.	alpha- Amino- 3- hydroxy- 5- methyl- 4- isoxazolepropionic Acid (AMPA)

Related Therapies and Procedures

1.	Spinal Injections
2.	Injections
3.	Laminectomy
4.	Implanted Electrodes
5.	Anesthesia