Proto-Oncogene Proteins c-abl
Non-receptor tyrosine kinases encoded by the C-ABL GENES. They are distributed in both the cytoplasm and the nucleus. c-Abl plays a role in normal HEMATOPOIESIS especially of the myeloid lineage. Oncogenic transformation of c-abl arises when specific N-terminal amino acids are deleted, releasing the kinase from negative regulation.
Also Known As:
Proto-Oncogene Proteins abl; abl Proto-Oncogene Products; Products, abl Proto-Oncogene; Proteins abl, Proto-Oncogene; Proto Oncogene Proteins abl; Proto Oncogene Proteins c abl; Proto-Oncogene Products, abl; Proto-Oncogene Proteins, abl; abl Proto Oncogene Products; abl Proto Oncogene Proteins; abl, Proto-Oncogene Proteins; c abl Proteins; c-abl, Proto-Oncogene Proteins; abl Proto-Oncogene Proteins; c-abl Proteins
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Bio-Agent Context: Research Results