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Aspartic Acid Endopeptidases
A sub-subclass of endopeptidases that depend on an ASPARTIC ACID residue for their activity.
Also Known As:
Aspartyl Endopeptidases; Acid Endopeptidases, Aspartic; Endopeptidases, Aspartic Acid; Endopeptidases, Aspartyl; Aspartic Endopeptidases
Networked:
2
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Enzymes and Coenzymes: 1
Enzymes: 152586
Hydrolases: 2166
Peptide Hydrolases: 23957
Endopeptidases: 633
Aspartic Acid Endopeptidases: 2
Renin: 12564
Cathepsin D: 1695
Pepsin A: 1488
Chymosin: 193
Endothelin-Converting Enzymes: 165
HIV Protease: 103
Cathepsin E: 81
plasmepsin: 63
signal peptide peptidase: 28
plasmepsin II: 19
signal peptidase II: 11
aspergillopepsin II: 10
phytepsin: 7
HTLV-1 protease: 5
protease p15: 3
allergen Bla g 2: 2
aspartic proteinase A: 2
FIV protease: 2
Irpex lacteus aspartic proteinase: 2
pregnancy-associated glycoprotein 1: 2
SIV(mac) proteinase: 2
canditropsin: 1
human signal peptide peptidase like 3: 1
pronapsin: 1
proplasmepsin II: 1
ALP56 enzyme
Ancylostoma caninum Acasp1 protein
Arabidopsis ASPG1 protein
Arabidopsis AT1G11910 protein
Arabidopsis CDR1 protein
Arabidopsis PCS1 proteinase
Arabidopsis SPP protein
aspartic proteinase-I
aspergillopepsin I
Aspergillus acid proteinase
Aspergillus niger AP 114 protease
Aspergillus niger PepE protein
Aspergillus oryzae carboxyl proteinase
Boophilus yolk pro-cathepsin
byssochlamyopeptidase A
Candida albicans SAP1 protein
Candida albicans Sap10 protein
Candida albicans SAP3 protein
Candida albicans SAP4 protein
Candida albicans SAP5 protein
Candida albicans SAP6 protein
Candida albicans Sap8 protein
Candida albicans Sap9 protein
Candida parapsilosis SAPP1 protein
Candida pulcherrima extracellular carboxyl proteinase
Candida SAP2 protein
Cryphonectria parasitica EapB protein
Cryphonectria parasitica EapC protein
Cynara cardunculus aspartic proteinases
cyprosin
Drosophila Bace protein
Drosophila DASP1 protein
Drosophila SppL protein
Drosophila Ulysses retrotransposon aspartic proteinase
eimepsin
Endothia aspartic proteinase
foamy virus proteinase
human BACE1 protein
human BACE2 protein
human NAPSA protein
human presenilinase
human skin aspartic protease
human SPPL2a protein
human SPPL2b protein
human SPPL2C protein
kumamolysin
microbial aspartic proteinases
Moloney murine leukemia virus protease
mouse Bace1 protein
mouse Bace2 protein
mouse Ddi1 protein
mouse Kdap protein
mouse SPPL2a protein
mouse SPPL2b protein
mouse Sppl2c protein
mouse Sval1 protein
mouse Sval2 protein
mouse Taps protein
nucellin
oryzasin
plasmapepsin IV
podosporapepsin
pregnancy-associated glycoprotein 2
procardosin A
rat Bace1 protein
rat Bace2 protein
rat Napsa protein
rat Sval1 protein
rat Sval2 protein
rennin-like enzyme (Aspergillus ochraceus)
rhizopuspepsin
rhizopuspepsinogen
rhodopsin cleaving enzyme
Rous sarcoma virus protease
S cerevisiae BAR1 protein
Aspartic Acid Proteases: 410
Aspartic Acid Endopeptidases: 2
Renin: 12564
Cathepsin D: 1695
Pepsin A: 1488
Chymosin: 193
Endothelin-Converting Enzymes: 165
HIV Protease: 103
Cathepsin E: 81
plasmepsin: 63
signal peptide peptidase: 28
plasmepsin II: 19
signal peptidase II: 11
aspergillopepsin II: 10
Secreted Aspartic Proteases: 10
phytepsin: 7
HTLV-1 protease: 5
protease p15: 3
allergen Bla g 2: 2
aspartic proteinase A: 2
FIV protease: 2
Irpex lacteus aspartic proteinase: 2
pregnancy-associated glycoprotein 1: 2
SIV(mac) proteinase: 2
canditropsin: 1
human signal peptide peptidase like 3: 1
pronapsin: 1
proplasmepsin II: 1
ALP56 enzyme
Ancylostoma caninum Acasp1 protein
Arabidopsis ASPG1 protein
Arabidopsis AT1G11910 protein
Arabidopsis CDR1 protein
Arabidopsis PCS1 proteinase
Arabidopsis SPP protein
aspartic proteinase-I
aspergillopepsin I
Aspergillus acid proteinase
Aspergillus niger AP 114 protease
Aspergillus niger PepE protein
Aspergillus oryzae carboxyl proteinase
Boophilus yolk pro-cathepsin
byssochlamyopeptidase A
Candida albicans SAP1 protein
Candida albicans Sap10 protein
Candida albicans SAP3 protein
Candida albicans SAP4 protein
Candida albicans SAP5 protein
Candida albicans SAP6 protein
Candida albicans Sap8 protein
Candida albicans Sap9 protein
Candida parapsilosis SAPP1 protein
Candida pulcherrima extracellular carboxyl proteinase
Candida SAP2 protein
Cryphonectria parasitica EapB protein
Cryphonectria parasitica EapC protein
Cynara cardunculus aspartic proteinases
cyprosin
Drosophila Bace protein
Drosophila DASP1 protein
Drosophila SppL protein
Drosophila Ulysses retrotransposon aspartic proteinase
eimepsin
Endothia aspartic proteinase
foamy virus proteinase
human BACE1 protein
human BACE2 protein
human NAPSA protein
human presenilinase
human skin aspartic protease
human SPPL2a protein
human SPPL2b protein
human SPPL2C protein
kumamolysin
microbial aspartic proteinases
Moloney murine leukemia virus protease
mouse Bace1 protein
mouse Bace2 protein
mouse Ddi1 protein
mouse Kdap protein
mouse SPPL2a protein
mouse SPPL2b protein
mouse Sppl2c protein
mouse Sval1 protein
mouse Sval2 protein
mouse Taps protein
nucellin
oryzasin
plasmapepsin IV
podosporapepsin
pregnancy-associated glycoprotein 2
procardosin A
rat Bace1 protein
rat Bace2 protein
rat Napsa protein
rat Sval1 protein
rat Sval2 protein
rennin-like enzyme (Aspergillus ochraceus)
rhizopuspepsin
rhizopuspepsinogen
rhodopsin cleaving enzyme
Rous sarcoma virus protease
Related Diseases
1.
Infections
11/01/1997 - "
Aspartic endopeptidases (plasmepsins) have been implicated in the degradation of hemoglobin in the erythrocytic stage of infection by Plasmodium falciparum.
"
2.
Hypertension (High Blood Pressure)
09/21/2023 - "
The top-ranking concepts relating COVID-19 to resistant hypertension included: cGMP-dependent protein kinase II, MAP3K1, haspin, ral guanine nucleotide exchange factor, N-(3-Oxododecanoyl)-L-homoserine lactone, aspartic endopeptidases, metabotropic glutamate receptors, choline-phosphate cytidylyltransferase, protein tyrosine phosphatase, tat genes, MAP3K10, uridine kinase, dicer enzyme, CMD1B, USP17L2, FLNA, exportin 5, somatotropin releasing hormone, beta-melanocyte stimulating hormone, pegylated leptin, beta-lipoprotein, corticotropin, growth hormone-releasing peptide 2, pro-opiomelanocortin, alpha-melanocyte stimulating hormone, prolactin, thyroid hormone, poly-beta-hydroxybutyrate depolymerase, CR 1392, BCR-ABL fusion gene, high density lipoprotein sphingomyelin, pregnancy-associated murine protein 1, recQ4 helicase, immunoglobulin heavy chain variable domain, aglycotransferrin, host cell factor C1, ATP6V0D1, imipramine demethylase, TRIM40, H3C2 gene, COL1A1+COL1A2 gene, QARS gene, VPS54, TPM2, MPST, EXOSC2, ribosomal protein S10, TAP-144, gonadotropins, human gonadotropin releasing hormone 1, beta-lipotropin, octreotide, salmon calcitonin, des-n-octanoyl ghrelin, liraglutide, gastrins.
"
3.
COVID-19
09/21/2023 - "
The top-ranking concepts relating COVID-19 to resistant hypertension included: cGMP-dependent protein kinase II, MAP3K1, haspin, ral guanine nucleotide exchange factor, N-(3-Oxododecanoyl)-L-homoserine lactone, aspartic endopeptidases, metabotropic glutamate receptors, choline-phosphate cytidylyltransferase, protein tyrosine phosphatase, tat genes, MAP3K10, uridine kinase, dicer enzyme, CMD1B, USP17L2, FLNA, exportin 5, somatotropin releasing hormone, beta-melanocyte stimulating hormone, pegylated leptin, beta-lipoprotein, corticotropin, growth hormone-releasing peptide 2, pro-opiomelanocortin, alpha-melanocyte stimulating hormone, prolactin, thyroid hormone, poly-beta-hydroxybutyrate depolymerase, CR 1392, BCR-ABL fusion gene, high density lipoprotein sphingomyelin, pregnancy-associated murine protein 1, recQ4 helicase, immunoglobulin heavy chain variable domain, aglycotransferrin, host cell factor C1, ATP6V0D1, imipramine demethylase, TRIM40, H3C2 gene, COL1A1+COL1A2 gene, QARS gene, VPS54, TPM2, MPST, EXOSC2, ribosomal protein S10, TAP-144, gonadotropins, human gonadotropin releasing hormone 1, beta-lipotropin, octreotide, salmon calcitonin, des-n-octanoyl ghrelin, liraglutide, gastrins.
"
Related Drugs and Biologics
1.
Cyclic GMP-Dependent Protein Kinase Type II
2.
RecQ Helicases
3.
Host Cell Factor C1
4.
Ribonuclease III (RNase III)
5.
Karyopherins (Importin)
6.
ral Guanine Nucleotide Exchange Factor
7.
Choline-Phosphate Cytidylyltransferase
8.
beta-MSH
9.
Metabotropic Glutamate Receptors (Metabotropic Glutamate Receptor)
10.
Protein Tyrosine Phosphatases