Oncogene Protein gp140(v-fms)

Transforming glycoprotein coded by the fms oncogene from the Susan McDonough strain of feline sarcoma virus (SM-FeSV). The oncogene protein v-fms lacks sequences, which, in the highly homologous proto-oncogene protein c-fms (CSF-1 receptor), normally serve to regulate its tyrosine kinase activity. The missing sequences in v-fms mimic the effect of ligand and lead to constitutive cell growth. The protein gp120(v-fms) is post-translationally modified to generate gp140(v-fms).

Also Known As:

fms Oncogene Product gp120; fms Oncogene Product gp140; gp120 v-fms; gp140 v-fms; gp120 v fms; gp140 v fms; v fms Protein; v-fms, gp120; v-fms, gp140; fms Oncogene Protein gp120; fms Oncogene Protein gp140; gp120(v-fms); gp140(v-fms); v-fms Protein

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Viral Proteins: 4250
    - Viral Oncogene Proteins: 11
      - Oncogenic Retroviridae Proteins
        Oncogene Protein gp140(v-fms): 1
    - Retroviridae Proteins: 7
      - Oncogenic Retroviridae Proteins
        Oncogene Protein gp140(v-fms): 1
  - Neoplasm Proteins: 2
    - Oncogene Proteins: 7793
      - Viral Oncogene Proteins: 11
        Oncogenic Retroviridae Proteins
        Oncogene Protein gp140(v-fms): 1

Related Diseases

1.	Sarcoma (Soft Tissue Sarcoma) 10/01/1986 - "A new acute transforming feline retrovirus with fms homology specifies a C-terminally truncated version of the c-fms protein that is different from SM-feline sarcoma virus v-fms protein."

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