Dextran Sulfate

Long-chain polymer of glucose containing 17-20% sulfur. It has been used as an anticoagulant and also has been shown to inhibit the binding of HIV-1 to CD4-POSITIVE T-LYMPHOCYTES. It is commonly used as both an experimental and clinical laboratory reagent and has been investigated for use as an antiviral agent, in the treatment of hypolipidemia, and for the prevention of free radical damage, among other applications.

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Networked: 4519 relevant articles (427 outcomes, 1003 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Kim, Joo Sung: 23 articles (01/2021 - 02/2007)
2.	Surh, Young-Joon: 21 articles (03/2022 - 01/2008)
3.	Andoh, Akira: 19 articles (01/2022 - 04/2002)
4.	Tanaka, Takuji: 18 articles (01/2021 - 02/2005)
5.	Fujiyama, Yoshihide: 18 articles (01/2013 - 04/2002)
6.	Washington, M Kay: 17 articles (01/2022 - 04/2007)
7.	Wang, Jing: 16 articles (10/2022 - 06/2015)
8.	Kim, Nayoung: 16 articles (03/2021 - 02/2007)
9.	Ghia, Jean-Eric: 16 articles (02/2021 - 03/2008)
10.	Li, Yan: 15 articles (03/2022 - 06/2011)

Related Diseases

1.	Colitis 11/05/2023 - "20 mg/kg compound 1 resulted in remarkable colitis improvement in dextran sulfate sodium (DSS)-induced mice model by up-regulating HO-1 and down-regulating phosphorylation level of NF-κB p65. " 05/25/2017 - "The results were remarkable, suggesting that Lactobacillus fermentum HY01 had significant preventive effects in dextran sulfate sodium induced-colitis; simultaneously, the high dose group showed the best results among other groups. " 01/05/2023 - "Further studies revealed an important therapeutic effect of E6 on dextran sulfate sodium-induced colitis. " 01/01/2023 - "Profiting from the excellent RONS scavenging activities, TMNSs can down-regulate the expression levels of the pro-inflammatory factors, thereby leading to prominent therapeutic efficacy against dextran sulfate sodium-induced colitis. " 08/01/2022 - "The results of pharmacological evaluations demonstrated the excellent protective effects of BBH on colitis induced by dextran sulfate sodium (DSS). "
2.	Ulcerative Colitis 03/01/2019 - "In our study, we investigated the therapeutic efficacy of RPD and potential mechanism involved in inhibiting dextran sulfate sodium (DSS)-induced ulcerative colitis in mice. " 05/26/2015 - "In our study, we used current biomedical approaches to investigate the therapeutic efficacy of BXD and possible protective mechanism involved in inhibiting dextran sulfate sodium (DSS)-induced chronic ulcerative colitis model. " 08/30/2022 - "The purpose of this study is to investigate the protective effects and potential mechanisms of ZO extracted from ginger on dextran sulfate sodium (DSS)-induced mouse ulcerative colitis (UC). " 01/01/2012 - "The aim of this study was to investigate the protective effects of CA against dextran sulfate sodium (DSS)-induced ulcerative colitis (UC). " 07/07/2021 - "In the present investigation, the potential protective effects of whey fermented with probiotic Lactobacillus rhamnosus MTCC-5897 on gastrointestinal health in a murine ulcerative colitis model induced by dextran sulfate sodium (DSS) were evaluated. "
3.	Inflammation (Inflammations) 05/01/2021 - "Previous observations have shown that FIBCD1 ameliorates dextran sulfate sodium (DSS)-induced intestinal inflammation in vivo. " 01/01/2016 - "Inhibition of α2A-Adrenoceptors Ameliorates Dextran Sulfate Sodium-Induced Acute Intestinal Inflammation in Mice." 01/01/2011 - "Daily intrarectal administration of poly P (10 µg) improved the inflammation grade and survival rate in 4% sodium dextran sulfate-administered mice. " 05/01/1999 - "When compared to mice on a standard diet, mice given food supplemented with 0.5% BBIC during and after dextran sulfate sodium treatment showed suppression of three of four scored histopathological inflammation criteria (P < 0.01), total histopathological score (P < 0.01), a 15% lower mortality rate (P < 0.01), and a delayed onset of mortality. " 11/07/2023 - "This study examined the effects of Virofree on intestinal inflammation and the gut microbiota in mice using a dextran sulfate sodium (DSS)-induced model. "
4.	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 10/01/2014 - "This study aimed to elucidate the functional mechanism and therapeutic efficacy of bacterial β-(1,3)-glucan in dextran sulfate sodium (DSS)-induced inflammatory bowel disease (IBD).Mice were orally pretreated with bacterial β-(1,3)-glucan at daily doses of 2.5 or 5mg/kg for 2 weeks. " 03/01/2020 - "AIEC LF82 and dextran sulfate sodium were administrated into C57BL/6 mice for estabolishing inflammatory bowel disease model and for therapeutic study. " 01/01/2017 - "In this study, we aimed to investigate the effects of exosomes released from human umbilical cord mesenchymal stem cells (hucMSCs) on the treatment of dextran sulfate sodium- (DSS-) induced inflammatory bowel disease (IBD) and to explore the underlying mechanism. " 10/01/2023 - "Inhibition of NLRP3 attenuates sodium dextran sulfate-induced inflammatory bowel disease through gut microbiota regulation." 08/30/2023 - "Dextran sulfate sodium was used to model inflammatory bowel disease in mice, and Lactobacillus paracasei TK1501 fermented soybeans and their metabolites were used to treat inflammatory bowel disease. "
5.	Body Weight (Weight, Body) 01/01/2023 - "The administration of THLW significantly decreased the severity of dextran sulfate sodium (DSS)-induced intestinal damage, as demonstrated by the stabilization of body weight and colon length, and decreased disease activity index (DAI) and histological scores. " 01/01/2020 - "subtilis RZ001 may have significantly reduced symptoms such as the dextran sulfate sodium (DSS)-induced decrease in body weight, shortening of colon length and overproduction of proinflammatory factors. " 01/01/2018 - "Mice lacking Odc in myeloid cells (OdcΔmye mice) that were treated with dextran sulfate sodium (DSS) exhibited improved survival, body weight, and colon length and reduced histologic injury versus control mice. " 09/10/2020 - "In this study, we subjected rats to severe TBI (sTBI), testing the effects of a single subcutaneous administration, 30 min post-impact, of a new low molecular weight dextran sulfate, named ILB®, at three different dose levels (1, 5, and 15 mg/kg body weight). " 04/01/2020 - "The current study demonstrated that LYC treatment (50 mg/kg body weight/day) for 40 days prevented the dextran sulfate sodium (DSS)-induced gut barrier damages and inflammatory responses in male mice. "

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5.	Salts
6.	Lipopolysaccharides
7.	Polysaccharides (Glycans)
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10.	Therapeutic Uses

Related Therapies and Procedures

1.	Oral Administration
2.	Blood Component Removal (Apheresis)
3.	Therapeutics
4.	Fecal Microbiota Transplantation
5.	Plasmapheresis