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Anistreplase (APSAC)

An acylated inactive complex of streptokinase and human lysine-plasminogen. After injection, the acyl group is slowly hydrolyzed, producing an activator that converts plasminogen to plasmin, thereby initiating fibrinolysis. Its half-life is about 90 minutes compared to 5 minutes for TPA; (TISSUE PLASMINOGEN ACTIVATOR); 16 minutes for UROKINASE-TYPE PLASMINOGEN ACTIVATOR and 23 minutes for STREPTOKINASE. If treatment is initiated within 3 hours of onset of symptoms for acute myocardial infarction, the drug preserves myocardial tissue and left ventricular function and increases coronary artery patency. Bleeding complications are similar to other thrombolytic agents.
Also Known As:
APSAC; Anisoylated Plasminogen-Streptokinase Activator Complex; BRL-26921; Eminase; Iminase; BRL 26921; BRL26921
Networked: 253 relevant articles (27 outcomes, 89 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1. Chaffin, Mark: 2 articles (08/2008 - 02/2006)
2. Becker-Weidman, Arthur: 1 article (11/2006)
3. Donnis, Randi: 1 article (11/2006)
4. Lyon, Lynne: 1 article (11/2006)
5. Mercer, Jean: 1 article (11/2006)
6. Misbach, Alan: 1 article (11/2006)
7. Pennington, Randal: 1 article (11/2006)
8. Reilly, Kathryn Miller: 1 article (11/2006)
9. Rosa, Linda: 1 article (11/2006)
10. Barnett, Douglas: 1 article (02/2006)

Related Diseases

1. Myocardial Infarction
2. Infarction (Infarctions)
3. Thrombosis (Thrombus)
4. Pain (Aches)
5. Hemorrhage

Related Drugs and Biologics

1. Anistreplase (APSAC)
2. Streptokinase
3. Tissue Plasminogen Activator (Alteplase)
4. Fibrinolytic Agents (Antithrombotic Agents)
5. Urokinase-Type Plasminogen Activator (Urokinase)
6. Heparin (Liquaemin)
7. Plasminogen
8. Fibrin
9. streptokinase-plasminogen complex
10. Fibrinogen (Factor I)

Related Therapies and Procedures

1. Intravenous Infusions
2. Thrombolytic Therapy
3. Intravenous Injections
4. Therapeutics
5. Aftercare (After-Treatment)