|1.||Selkoe, Dennis J: 48 articles (01/2012 - 04/2002)|
|2.||Butterfield, D Allan: 31 articles (01/2010 - 06/2002)|
|3.||Haass, Christian: 30 articles (08/2010 - 07/2002)|
|4.||Teplow, David B: 30 articles (07/2010 - 01/2002)|
|5.||Masters, Colin L: 29 articles (01/2010 - 06/2002)|
|6.||Barnham, Kevin J: 25 articles (01/2010 - 01/2003)|
|7.||Lahiri, Debomoy K: 24 articles (01/2015 - 01/2002)|
|8.||Saido, Takaomi C: 24 articles (08/2010 - 05/2002)|
|9.||Walsh, Dominic M: 20 articles (05/2010 - 04/2002)|
|10.||Wolfe, Michael S: 19 articles (01/2014 - 04/2002)|
|1.||Alzheimer Disease (Alzheimer's Disease)
05/01/2010 - "Among these, strategies targeting the production and clearance of the amyloid-beta peptide - a cardinal feature of Alzheimer's disease that is thought to be important in disease pathogenesis - are the most advanced. "
01/01/2005 - "Over the past few years, amyloid beta protein (Abeta) vaccination has become one of the most effective treatments for Alzheimer's disease. "
06/01/2007 - "Accumulating evidence suggests that bone-marrow (BM)-derived mononuclear phagocytes have an important role in the clearance of soluble and aggregated amyloid-beta peptides (Abeta) in Alzheimer's disease (AD) brains. "
05/01/2005 - "As Alzheimer's disease pathogenesis is associated with the formation of insoluble aggregates of amyloid beta-peptide, approaches allowing the direct, noninvasive visualization of plaque growth in vivo would be beneficial for biomedical research. "
08/05/1991 - "In Alzheimer's disease beta-amyloid protein load in neocortex and hippocampus was significantly greater than in non-demented age-matched controls. "
05/01/2008 - "Recent studies using ABCA1 knockout mice have demonstrated that ABCA1 affects amyloid-beta peptide (A beta) levels in the brain and the production of senile plaque. "
05/01/2003 - "Aggregation of Amyloid beta-protein(A beta) in senile plaques is related to the pathogenesis of AD, so it is very important for the studies on the prevention of A beta deposition and on trying to disaggregate the senile plaques, aimed at treatment and prevention of the AD. "
03/07/2003 - "In this study we report that amyloid beta-peptides (Abeta) increased AChE levels in both neuronal and astrocytic primary cultures, supporting the possibility that both neurons and glia may make a direct contribution to the pool of AChE seen around amyloid deposits in the AD brain."
08/01/2000 - "Recent studies have demonstrated the generation of beta-amyloid protein (Abeta) 1-42, a key peptide for amyloid deposits, in the ER. "
12/01/1998 - "Recent studies suggest that mutations in APP, PS 1 or PS 2 result in increased production of amyloid beta protein (A beta), a major constituent of senile plaques. "
10/01/2000 - "There are two pathological defects in AD: chronic inflammation and impaired clearance of amyloid beta-peptide (Abeta). "
10/01/2011 - "In the present work, we have characterised the induction of inflammation in the rat retina following intravitreal administration of amyloid-beta protein (Aβ). "
04/15/2010 - "Amyloid-beta peptide is the main inducer of inflammation in AD. "
12/01/2008 - "However, the pathological pathways from amyloid-beta peptide oligomerization to the major pathological hallmarks of AD, such as neurofibrillary tangles, inflammation and loss of cholinergic neurons, are largely unknown. "
07/01/2005 - "Amyloid beta peptide 1-40 enhances the action of Toll-like receptor-2 and -4 agonists but antagonizes Toll-like receptor-9-induced inflammation in primary mouse microglial cell cultures."
04/01/2013 - "Impaired clearance of neurotoxic amyloid beta peptides (Abeta) leads to dementia in AD. "
07/16/2014 - "Plaques composed of aggregated amyloid-beta protein (Aβ) accumulate between the neural cells in the brain and are associated with dementia and cellular death. "
11/01/2012 - "A low beta amyloid protein rate (479 mg/L) found in cerebrospinal fluid suggests a possible link between SHANK3 deletion syndrome-associated regression and dementia of Alzheimers's type. "
09/23/2011 - "The experimental dementia models were established by injecting beta-amyloid protein 1-40 (Aβ1-40) stereotactically into the left lateral ventricle, and treated by injecting NRG1β into right lateral ventricle. "
09/01/2010 - "This theory posits that the deposition of amyloid-beta protein (Abeta) in the brain is the key pathologic event in AD, which induces a series of neuropathological changes that manifest as cognitive decline and eventual dementia. "
|5.||Cerebral Amyloid Angiopathy (Congophilic Angiopathy)
02/21/2007 - "Antibody-mediated clearance of amyloid-beta peptide from cerebral amyloid angiopathy revealed by quantitative in vivo imaging."
01/01/2015 - "Amyloid beta-peptides (Aβ) are known to undergo active transport across the blood-brain barrier, and cerebral amyloid angiopathy has been shown to be a prominent feature in the majority of Alzheimer׳s disease. "
08/01/2009 - "Cerebral amyloid angiopathy is caused by deposition of the amyloid beta protein in the cerebral vasculature. "
06/01/2008 - "Cerebral amyloid angiopathy (CAA) is characterized by the deposition of the amyloid beta-protein (A beta) within cerebral vessels. "
04/01/2006 - "Pathological measures of amyloid beta protein (Abeta), as plaque Abeta40 and Abeta42(3) load and degree of cerebral amyloid angiopathy were made by image analysis or semiquantitative rating, respectively. "
|2.||Amyloid (Amyloid Fibrils)
|4.||Insulysin (Insulin-Degrading Enzyme)
|6.||Neurotransmitter Agents (Neurotransmitter)
|8.||Apolipoproteins E (ApoE)
|10.||tau Proteins (tau Protein)