Endothelial Growth Factors

These growth factors are soluble mitogens secreted by a variety of organs. The factors are a mixture of two single chain polypeptides which have affinity to heparin. Their molecular weight are organ and species dependent. They have mitogenic and chemotactic effects and can stimulate endothelial cells to grow and synthesize DNA. The factors are related to both the basic and acidic FIBROBLAST GROWTH FACTORS but have different amino acid sequences.

Also Known As:

ECDGF; Endo-GF; Endothelial Growth Factor; Endothelial Growth Factor Polypeptides; Endothelial Cell Derived Growth Factors; Growth Factor, Endothelial; Growth Factor, alpha-Endothelial; Growth Factor, beta-Endothelial; Growth Factors, Endothelial; alpha Endothelial Growth Factor; beta Endothelial Growth Factor; Endothelial Cell-Derived Growth Factors; alpha-Endothelial Growth Factor; beta-Endothelial Growth Factor

Networked: 760 relevant articles (63 outcomes, 102 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Freund, K Bailey: 11 articles (05/2022 - 09/2009)
2.	Garg, Sunir J: 6 articles (12/2022 - 11/2013)
3.	Ho, Allen C: 6 articles (12/2022 - 06/2014)
4.	Hsu, Jason: 6 articles (12/2022 - 06/2014)
5.	Gillies, Mark C: 6 articles (07/2021 - 03/2015)
6.	Bandello, Francesco: 6 articles (01/2020 - 01/2010)
7.	Barthelmes, Daniel: 5 articles (07/2021 - 03/2015)
8.	Chhablani, Jay: 5 articles (01/2018 - 12/2015)
9.	Regillo, Carl D: 4 articles (12/2022 - 06/2014)
10.	Sarraf, David: 4 articles (05/2022 - 09/2013)

Related Diseases

1.	Macular Edema 05/01/2023 - "He received intravitreal antivascular endothelial growth factor treatment with subsequent improvement in VA and resolution of the macular edema. " 01/01/2020 - "This study suggests that it is possible to combine fundus autofluorescence results with functional and structural variables into normalized indexes that could potentially predict outcomes after antivascular endothelial growth factor loading dose in patients with diabetic macular edema." 01/01/2023 - "DEFINING "STRONG" VERSUS "WEAK" RESPONSE TO ANTIVASCULAR ENDOTHELIAL GROWTH FACTOR TREATMENT FOR CENTER-INVOLVED DIABETIC MACULAR EDEMA." 07/15/2022 - "Predictive value of the characteristics of intraretinal cystoid spaces on early response to antivascular endothelial growth factor treatment in patients with cystoid diabetic macular edema." 03/01/2021 - "Evaluation of Patients Receiving Intravitreal Antivascular Endothelial Growth Factor for Diabetic Macular Edema in Clinical Practice in the United States."
2.	Macular Degeneration (Age-Related Maculopathy) 06/01/2023 - "A patient in her 90s was diagnosed with Type 3 macular neovascularization secondary to age-related macular degeneration in the index right eye and underwent intravitreal antivascular endothelial growth factor treatment for 5 years. " 01/01/2023 - "Effects of antivascular endothelial growth factor drug treatment on changes in vitreomacular interface, intraocular pressure and visual acuity of patients with age-related macular degeneration." 01/01/2023 - "Antivascular endothelial growth factor agents for wet age-related macular degeneration: an IRIS registry analysis." 12/01/2021 - "We found an association between the frequency and number of treatments with antivascular endothelial growth factor agents and the development of GA in neovascular age-related macular degeneration. " 09/01/2021 - "A subset (13.76%; 63/458, 95% confidence intervals: 10.73-17.25) of patients with treatment-naive wet age-related macular degeneration demonstrates resolution of choroidal neovascular membrane-associated exudation with a single antivascular endothelial growth factor injection, sustained over 2 years or more. "
3.	Neoplasms (Cancer) 06/01/2016 - "Antivascular endothelial growth factor, which was originally developed for treating cancers, has emerged to be a potentially effective treatment for CSCR. " 05/01/2007 - "Moreover, destruction of established tumor mass by treatment with an antivascular endothelial growth factor antibody was markedly enhanced in Cnn1-deficient mice. " 05/01/2003 - "Treatment of mice bearing a small ear tumor with a humanized antivascular endothelial growth factor antibody prevented the down-regulation of leukocyte-vessel wall interactions inside the tumor vessels compared with the nontreated group. " 09/01/1998 - "Vascular density was significantly lower in antivascular endothelial growth factor antibody-treated tumors, compared with control tumors of similar size. " 09/01/1998 - "Antivascular endothelial growth factor antibody treatment was administered for a period of 6 weeks, to suppress tumor growth. "
4.	Diabetic Retinopathy (Retinopathy, Diabetic) 01/01/2022 - "This study reports updated clinical outcomes in patients undergoing PPV for proliferative diabetic retinopathy-related complications which compares favorably with the age before small-gauge PPV and antivascular endothelial growth factor pretreatment." 01/01/2022 - "There were 943 subjects who prospectively underwent small-gauge PPV with antivascular endothelial growth factor pretreatment for proliferative diabetic retinopathy-related complications and completed 6-month follow-up. " 01/01/2017 - "Diabetic Retinopathy and Antivascular Endothelial Growth Factor Agents." 10/01/2014 - "Surgical outcomes of florid diabetic retinopathy treated with antivascular endothelial growth factor." 01/01/2010 - "Antivascular endothelial growth factor in diabetic retinopathy."
5.	Choroidal Neovascularization 01/01/2014 - "The use of antivascular endothelial growth factor in the management of cuticular drusen-associated choroidal neovascularization seems to be an effective method of treatment showing both resolution of optical coherence tomography changes and improvement in visual acuity in this case. " 01/01/2023 - "The second patient developed unilateral choroidal neovascularization 3 days after vaccination and required intravitreal antivascular endothelial growth factor injection. " 04/01/2015 - "Clinical characteristics and antivascular endothelial growth factor effect of choroidal neovascularization in younger patients in Taiwan." 01/01/2010 - "In recent years, several case reports and case series have shown that intravitreal injections of antivascular endothelial growth factor drugs can be effective in treating subfoveal choroidal neovascularization secondary to chorioretinal dystrophies either improving vision, or at least halting its progressive loss. " 11/01/2023 - "BILATERAL PERIPAPILLARY CHOROIDAL NEOVASCULARIZATION IN AN OTHERWISE HEALTHY TEENAGER TREATED WITH ANTIVASCULAR ENDOTHELIAL GROWTH FACTOR INJECTIONS."

Related Drugs and Biologics

1.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
2.	Bevacizumab (Avastin)
3.	Adrenal Cortex Hormones (Corticosteroids)
4.	1-phenyl-3,3-dimethyltriazene (PDT)
5.	Ranibizumab (Lucentis)
6.	Steroids
7.	Triamcinolone Acetonide (Azmacort)
8.	Monoclonal Antibodies
9.	aflibercept
10.	Dexamethasone (Maxidex)

Related Therapies and Procedures

1.	Therapeutics
2.	Drug Therapy (Chemotherapy)
3.	Vitrectomy
4.	Photochemotherapy (Photodynamic Therapy)
5.	Intravitreal Injections