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Fibroblast Growth Factor 2 (Basic Fibroblast Growth Factor)

A single-chain polypeptide growth factor that plays a significant role in the process of WOUND HEALING and is a potent inducer of PHYSIOLOGIC ANGIOGENESIS. Several different forms of the human protein exist ranging from 18-24 kDa in size due to the use of alternative start sites within the fgf-2 gene. It has a 55 percent amino acid residue identity to FIBROBLAST GROWTH FACTOR 1 and has potent heparin-binding activity. The growth factor is an extremely potent inducer of DNA synthesis in a variety of cell types from mesoderm and neuroectoderm lineages. It was originally named basic fibroblast growth factor based upon its chemical properties and to distinguish it from acidic fibroblast growth factor (FIBROBLAST GROWTH FACTOR 1).
Also Known As:
Basic Fibroblast Growth Factor; FGF 2; FGF2; Fibroblast Growth Factor, Basic; Cartilage-Derived Growth Factor; Class II Heparin-Binding Growth Factor; FGF-2; Fibroblast Growth Factor-2; Heparin-Binding Growth Factor Class II; Prostate Epithelial Cell Growth Factor; Prostatropin; Cartilage Derived Growth Factor; HBGF-2
Networked: 5472 relevant articles (194 outcomes, 771 trials/studies)

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Bio-Agent Context: Research Results

Experts

1. Tabata, Yasuhiko: 53 articles (01/2022 - 07/2002)
2. Xiao, Jian: 24 articles (01/2021 - 12/2009)
3. Presta, Marco: 20 articles (05/2021 - 06/2003)
4. Li, Xiaokun: 19 articles (01/2021 - 07/2007)
5. Yang, Li: 16 articles (01/2022 - 06/2003)
6. Hurley, Marja M: 16 articles (12/2021 - 06/2003)
7. Ribatti, Domenico: 15 articles (09/2019 - 12/2004)
8. Kardami, Elissavet: 15 articles (01/2019 - 02/2002)
9. Komeda, Masashi: 15 articles (12/2008 - 07/2002)
10. Ronca, Roberto: 13 articles (09/2019 - 06/2003)

Related Diseases

1. Neoplasms (Cancer)
2. Wounds and Injuries (Trauma)
3. Ischemia
4. Myocardial Infarction
5. Cicatrix (Scar)

Related Drugs and Biologics

1. Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
2. Fibroblast Growth Factor 2 (Basic Fibroblast Growth Factor)
3. Intercellular Signaling Peptides and Proteins (Growth Factors)
4. Gelatin
5. Hydrogels
6. Proteins (Proteins, Gene)
7. Platelet-Derived Growth Factor
8. Collagen
9. Brain-Derived Neurotrophic Factor (BDNF)
10. Transforming Growth Factors (Transforming Growth Factor)

Related Therapies and Procedures

1. Therapeutics
2. Transplantation
3. Injections
4. Drug Therapy (Chemotherapy)
5. Skin Transplantation (Skin Grafting)