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Fibroblast Growth Factor 1 (FGF-1)

A 17-kDa single-chain polypeptide growth factor that plays a significant role in the process of WOUND HEALING and is a potent inducer of PHYSIOLOGIC ANGIOGENESIS. It binds to HEPARIN, which potentiates its biological activity and protects it from proteolysis. The growth factor is an extremely potent inducer of DNA synthesis in a variety of cell types from mesoderm and neuroectoderm lineages, and also has chemotactic and mitogenic activities. It was originally named acidic fibroblast growth factor based upon its chemical properties and to distinguish it from basic fibroblast growth factor (FIBROBLAST GROWTH FACTOR 2).
Also Known As:
FGF-1; Acidic Fibroblast Growth Factor; FGF1; Fibroblast Growth Factor-1; Heparin Binding Growth Factor, Class I; Class I Heparin-Binding Growth Factor; Fibroblast Growth Factor, Acidic; HBGF-1; Heparin-Binding Fibroblast Growth Factor Class I; Heparin-Binding Growth Factor, Class I; Fibroblast growth factor (human brain acidic protein moiety reduced)
Networked: 476 relevant articles (17 outcomes, 65 trials/studies)

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Bio-Agent Context: Research Results

Experts

1. Prudovsky, Igor: 10 articles (08/2015 - 07/2002)
2. Cheng, Henrich: 8 articles (09/2011 - 07/2004)
3. Li, Xiaokun: 7 articles (12/2014 - 04/2007)
4. Tarantini, Francesca: 7 articles (03/2012 - 07/2002)
5. Zheng, Qing: 6 articles (03/2014 - 03/2006)
6. Huang, Wen-Cheng: 5 articles (09/2011 - 08/2005)
7. Yu, Chin: 5 articles (12/2010 - 10/2005)
8. Landriscina, M: 5 articles (12/2006 - 01/2001)
9. Maciag, T: 5 articles (12/2006 - 01/2001)
10. Prudovsky, I: 5 articles (12/2006 - 01/2001)

Related Diseases

1. Ischemia
2. Neoplasms (Cancer)
3. Breast Neoplasms (Breast Cancer)
4. Reperfusion Injury
5. Carcinoma (Carcinomatosis)

Related Drugs and Biologics

1. Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
2. Fibroblast Growth Factor 2 (Basic Fibroblast Growth Factor)
3. Vascular Endothelial Growth Factor Receptors (VEGF Receptors)
4. p38 Mitogen-Activated Protein Kinases
5. Thromboplastin (Tissue Factor)
6. RNA (Ribonucleic Acid)
7. angiogenin
8. Fibroblast Growth Factor 1 (FGF-1)
9. Fibroblast Growth Factor Receptors (Fibroblast Growth Factor Receptor)
10. Messenger RNA (mRNA)

Related Therapies and Procedures

1. Transplants (Transplant)
2. Heterologous Transplantation (Xenotransplantation)
3. Amputation
4. Homologous Transplantation (Allograft)
5. Axotomy