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Methacholine Chloride (Methacholine)

A quaternary ammonium parasympathomimetic agent with the muscarinic actions of ACETYLCHOLINE. It is hydrolyzed by ACETYLCHOLINESTERASE at a considerably slower rate than ACETYLCHOLINE and is more resistant to hydrolysis by nonspecific CHOLINESTERASES so that its actions are more prolonged. It is used as a parasympathomimetic bronchoconstrictor agent and as a diagnostic aid for bronchial asthma. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1116)
Also Known As:
Methacholine; Provocholine; 2-(Acetyloxy)-N,N,N-trimethyl-1-propanaminium Chloride; Acetyl-2-methylcholine Chloride; Acetyl-beta-methacholine Chloride; Acetyl-beta-methylcholine; Lindopharm Brand of Methacholine Chloride; Mecholine; Mecholyl; Methapharma Brand of Methacholine Chloride; Provokit; Roche Brand of Methacholine Chloride; Acetyl 2 methylcholine Chloride; Acetyl beta methacholine Chloride; Acetyl beta methylcholine; Chloride, Methacholine; 1-Propanaminium, 2-(acetyloxy)-N,N,N-trimethyl-, chloride
Networked: 2716 relevant articles (114 outcomes, 325 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1. Gelfand, Erwin W: 20 articles (02/2015 - 07/2002)
2. Boulet, Louis-Philippe: 17 articles (07/2015 - 08/2002)
3. Takeda, Katsuyuki: 17 articles (02/2015 - 07/2002)
4. Cockcroft, Donald W: 15 articles (07/2015 - 09/2004)
5. Prieto, Luis: 15 articles (02/2015 - 01/2002)
6. Postma, D S: 15 articles (12/2014 - 09/2000)
7. Koh, Young Yull: 15 articles (09/2011 - 10/2002)
8. Yoo, Young: 14 articles (01/2015 - 09/2003)
9. Lipworth, Brian J: 13 articles (06/2013 - 06/2002)
10. Weiss, Scott T: 13 articles (09/2012 - 06/2002)

Related Diseases

1. Asthma (Bronchial Asthma)
2. Inflammation
3. Bronchial Spasm
4. Cough
5. Bronchial Hyperreactivity

Related Drugs and Biologics

1. Adenosine Monophosphate (AMP)
2. Albuterol (Salbutamol)
3. Histamine (Histamine Dihydrochloride)
4. Adenosine
5. salmeterol (Serevent)
6. fluticasone (Cutivate)
7. Nitroprusside (Sodium Nitroprusside)
8. Ipratropium (Ipratropium Bromide)
9. Theophylline (Theon)
10. Adrenal Cortex Hormones (Corticosteroids)

Related Therapies and Procedures

1. Aftercare (After-Treatment)
2. Nebulizers and Vaporizers (Inhaler)
3. Kidney Transplantation
4. Catheters
5. Tocolysis