Maturation-Promoting Factor

Protein kinase that drives both the mitotic and meiotic cycles in all eukaryotic organisms. In meiosis it induces immature oocytes to undergo meiotic maturation. In mitosis it has a role in the G2/M phase transition. Once activated by CYCLINS; MPF directly phosphorylates some of the proteins involved in nuclear envelope breakdown, chromosome condensation, spindle assembly, and the degradation of cyclins. The catalytic subunit of MPF is PROTEIN P34CDC2.
Also Known As:
Histone H1 Kinase, Growth-Associated; Histone H1 Kinase, Growth Associated; Histone H1 Kinase, M Phase Specific; M Phase Promoting Factor; Maturation Promoting Factor; Mitosis Promoting Factor; Histone H1 Kinase, M-Phase-Specific; M Phase-Promoting Factor; Mitosis-Promoting Factor
Networked: 10 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results


1. Qi, Zhong-zheng: 1 article (06/2007)
2. Shang, De-hao: 1 article (06/2007)
3. Qu, Chang-feng: 1 article (06/2007)
4. Sun, Chang-fu: 1 article (06/2007)
5. Szeberenyl, Jozsef: 1 article (03/2007)
6. Lankat-Buttgereit, B: 1 article (12/2004)
7. Göke, R: 1 article (12/2004)
8. Samans, B: 1 article (12/2004)
9. Schmidt, A: 1 article (12/2004)
10. Barth, P: 1 article (12/2004)

Related Diseases

1. Adenoid Cystic Carcinoma (Cylindroma)
2. Chromosome Breakage
3. Neoplasms (Cancer)
4. Infection
5. Tetraploidy

Related Drugs and Biologics

1. Cyclins
2. Phosphotransferases (Kinase)
3. Cyclin B1
4. Proteasome Endopeptidase Complex (Proteasome)
5. Intercellular Signaling Peptides and Proteins (Growth Factors)
6. Cyclin B
7. Cyclin-Dependent Kinases (cdk Proteins)
8. Thymidine
9. Histones (Histone)
10. DNA (Deoxyribonucleic Acid)