(R)- 2,3,4,5- Tetrahydro- 8- chloro- 3- methyl- 5- phenyl- 1H- 3- benzazepin- 7- ol

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18 relevant articles (1 outcomes, 0 trials/studies) found for this Bio-Agent

Description: A dopamine D1 receptor antagonist that has no effect or only very limited effect on dopamine D2 receptors. The compound has tranquilizing effects, inhibits conditioned avoidance response, impairs memory acquisition, produces dose-dependent catalepsy, blocks central serotonin receptors, and reduces the lethal effects of cocaine.

Also Known As:

Sch-23388; Sch-23390; Sch 23388; Sch23388; 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-3-methyl-5-phenyl-, (R)-

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 23

2-Ring Heterocyclic Compounds

Benzazepines: 2

(R)-2,3,4,5-Tetrahydro-8-chloro-3-methyl-5-phenyl-1H-3-benzazepin-7-ol: 18

Sch 23982: 2

5-(4'-aminophenyl)-8-chloro-2,3,4,5-tetrahydro-3-methy-1H-3-benzazepin-7-ol: 1

2'-tricarbonylcyclopentadienylrhenium-SCH-23390

3'-tricarbonylcyclopentadienylrhenium-SCH-23390

7-chloro-8-hydroxy-1-(4'-formylphenyl)-3-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine

7-chloro-8-hydroxy-3-(3'-fluoropropyl)-1-phenyl-2,3,4,5-tetrahydro-3-benzazepine

7-chloro-8-hydroxy-3-(6-(dimethylamino)hexyl)-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine

7-chloro-8-hydroxy-3-(6-(N,N-dimethylamino)hexyl)-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine-cyanoborane

Sch 24518

SK&F 83692

Related Diseases

1.	Self Mutilation 02/01/1998 - "SCH-23390 eliminated L-dopa induced self-mutilation in all subjects, while risperidone eliminated self-mutilation in all but one subject." 02/01/1990 - "SCH-12679 antagonized the self-mutilation behavior and behavioral responses induced by L-dihydroxyphenylalanine in neonatal-6-OHDA lesioned rats in a manner similar to the prototypic D1-dopamine antagonist SCH-23390 and, like SCH-23390, produced a deficit in avoidance responding in unlesioned rats" Get all the results and reference details, order at left...
2.	Ganglion Cysts (Ganglion) 08/01/1986 - "Again, however, the DA1 receptor antagonist SCH-23390 failed to antagonize the ganglion blocking effect of dopamine" 08/01/1986 - "However, the more potent and selective DA1 receptor antagonist SCH-23390 failed to antagonize ganglion blocking effect of fenoldopam indicating that DA1 receptor in sympathetic ganglia is different from that in blood vessels" 01/01/1992 - "The D1-dopamine antagonist SCH-23390 and D2-dopamine antagonist spiperone reversed the dopamine-induced stimulation of ganglion cells and inhibited their maintained activity, which suggests that dopamine acts via both D1- and D2-receptors" Get all the results and reference details, order at left...
3.	Hypothermia 10/01/1991 - "SCH-23390 (0.1-3.0 mg/kg, ip), a D1 antagonist, had no effect on quinpirole-induced hypothermia and potentiated the hypothermia when administered icv" 05/01/1999 - "Thus, the hypothermia produced by clozapine (2.5 mg kg(-1)) in the rat is fully antagonised by either of the selective DA D1 receptor antagonists SCH-23390 (0.1 mg kg(-1)) or NNC-687 (4 mg kg(-1))" Get all the results and reference details, order at left...
4.	Anorexia 03/01/1999 - "SCH-23390, a DA1 antagonist, increased IMB anorexia" 06/01/2001 - "SCH-23390, however, completely blocked the anorexia induced by D-amphetamine (0.3 mg/kg ip)" Get all the results and reference details, order at left...
5.	Dyskinesias (Dyskinesia) 05/01/1992 - "Administration of the D1 antagonist SCH-23390 1 hour before administration of (+)-PHNO did not change the dyskinesia" Get all the results and reference details, order at left...
14 Diseases and 18 more articles analyzed in the Research Interface, order at left...

Related Drugs and Biologics

1.	Risperidone (Risperdal Consta)
2.	Levodopa (L Dopa)
3.	Dopamine (Intropin)
4.	Clozapine (Clozaril)
5.	Quinpirole
6.	Dopamine D1 Receptors (Dopamine D1 Receptor)
7.	Atropine (Hyoscyamine)
8.	hydroxide ion
9.	5-HT1A Serotonin Receptor
10.	Raclopride
31 Drugs and Important Bio-Agents and 16 more articles analyzed in the Research Interface, order at left...

Related Therapies and Procedures

1.	Induced Hypothermia
1 Therapies and Procedures and 1 more articles analyzed in the Research Interface, order at left...

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