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Dystrophin

A muscle protein localized in surface membranes which is the product of the Duchenne/Becker muscular dystrophy gene. Individuals with Duchenne muscular dystrophy usually lack dystrophin completely while those with Becker muscular dystrophy have dystrophin of an altered size. It shares features with other cytoskeletal proteins such as SPECTRIN and alpha-actinin but the precise function of dystrophin is not clear. One possible role might be to preserve the integrity and alignment of the plasma membrane to the myofibrils during muscle contraction and relaxation. MW 400 kDa.
Networked: 2842 relevant articles (44 outcomes, 180 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Chamberlain, Jeffrey S: 44 articles (01/2015 - 03/2002)
2. Duan, Dongsheng: 37 articles (12/2015 - 03/2002)
3. Takeda, Shin'ichi: 37 articles (05/2015 - 03/2002)
4. Matsuo, Masafumi: 36 articles (01/2016 - 01/2002)
5. Takeshima, Yasuhiro: 32 articles (01/2016 - 01/2002)
6. Aartsma-Rus, Annemieke: 29 articles (01/2015 - 10/2002)
7. Muntoni, Francesco: 28 articles (11/2014 - 07/2002)
8. Davies, Kay E: 27 articles (12/2015 - 04/2002)
9. Yagi, Mariko: 27 articles (01/2015 - 01/2002)
10. Dickson, George: 24 articles (08/2015 - 04/2002)

Related Diseases

1. Duchenne Muscular Dystrophy (Muscular Dystrophy, Becker)
2. Muscular Dystrophies (Muscular Dystrophy)
3. Necrosis
4. Muscular Diseases (Myopathy)
5. Cardiomyopathies (Cardiomyopathy)

Related Drugs and Biologics

1. Glycoproteins (Glycoprotein)
2. Utrophin
3. Dystroglycans (Dystroglycan)
4. Complementary DNA (cDNA)
5. Laminin (Merosin)
6. Carrier Proteins (Binding Protein)
7. Proteins (Proteins, Gene)
8. Protein Isoforms (Isoforms)
9. RNA Precursors (Precursor, mRNA)
10. Tubulin

Related Therapies and Procedures

1. Aftercare (After-Treatment)
2. Transplantation (Transplant Recipients)
3. Intramuscular Injections
4. Bone Marrow Transplantation (Transplantation, Bone Marrow)
5. Low-Level Laser Therapy (LLLT)