|1.||Suzuki, Takuji: 4 articles (01/2015 - 04/2008)|
|2.||Moritz, Thomas: 4 articles (10/2014 - 04/2008)|
|3.||Sleeman, M A: 3 articles (10/2015 - 08/2011)|
|4.||Anderson, I K: 3 articles (10/2015 - 08/2011)|
|5.||Cohen, E S: 3 articles (10/2015 - 08/2011)|
|6.||Lachmann, Nico: 3 articles (10/2014 - 01/2014)|
|7.||Renzi, Paolo M: 3 articles (12/2010 - 04/2002)|
|8.||Nash, A: 2 articles (10/2015 - 01/2013)|
|9.||McCourt, M: 2 articles (10/2015 - 01/2013)|
|10.||Wood, Robert E: 2 articles (10/2014 - 11/2010)|
09/01/2011 - "Mavrilimumab, a human monoclonal antibody targeting GM-CSF receptor-α, in subjects with rheumatoid arthritis: a randomised, double-blind, placebo-controlled, phase I, first-in-human study."
10/01/2015 - "Preclinical characterisation of the GM-CSF receptor as a therapeutic target in rheumatoid arthritis."
01/01/2013 - "Protein engineering and preclinical development of a GM-CSF receptor antibody for the treatment of rheumatoid arthritis."
12/01/2012 - "Mavrilimumab, a human monoclonal GM-CSF receptor-α antibody for the management of rheumatoid arthritis: a novel approach to therapy."
11/13/1993 - "Expression of GM-CSF receptor in rheumatoid arthritis."
06/01/1990 - "GM-CSF receptors distributed on these human tumor cells were low affinity types with an equilibrium dissociation constant of 1.5-10.0 nM. Cross-linking studies revealed that the molecular weights of the low affinity GM-CSF receptors were 65-85 kilodaltons. "
01/01/2013 - "Unexpectedly, an immune-independent antitumor effect was observed that depended on the ectopic expression of GM-CSF receptor subunits by tumors. "
09/01/2004 - "The four kinds of cancer cell lines had prominent GM-CSF receptor alpha subunit expression. "
08/01/1991 - "These results indicate that human tumor cells may express a low-affinity GM-CSF receptor protein that localizes to the cell surface and binds ligand, but lacks functional components or accessory factors needed to transduce a signal."
03/01/1989 - "Nonhematopoietic tumor cells express functional GM-CSF receptors."
|4.||Melanoma (Melanoma, Malignant)
08/01/1991 - "Cross-linking studies in the melanoma cell line, M14, showed a major GM-CSF receptor species of 84,000 daltons. "
08/01/1991 - "In the current study, we examine human melanoma cell lines and fresh specimens of melanoma to determine whether they have functional GM-CSF receptors. "
08/01/1991 - "Primary melanoma cells from five surgical specimens had GM-CSF receptors; Scatchard analysis was performed on one sample, showing 555 sites/cell with a kd of 0.23 nmol/L. "
09/01/2002 - "Eligible patients had solid tumours known to express GM-CSF receptors (breast, prostate, colon and lung cancer, and melanoma). "
08/01/2001 - "Immunohistochemical analysis with staining for CD14 and GM-CSF receptor demonstrated an increased infiltration of monocytes into both injected and noninjected cutaneous melanoma metastases compared with lesions excised prior to the initiation of therapy. "
|5.||Asthma (Bronchial Asthma)
05/01/1997 - "Upregulation of alpha GM-CSF-receptor in nonatopic asthma but not in atopic asthma."
05/01/1997 - "This study was carried out to investigate the expression of alpha GM-CSF receptor (alpha GM-CSFr) messenger RNA and protein in the bronchial mucosa of patients with intrinsic or atopic asthma and of control subjects and to correlate the expression of alpha GM-CSFr to the number of EG2+ cells (eosinophils) and CD68+ cells (macrophages) and pulmonary function. "
11/01/2014 - "Although many of the immunopathologic features of nonallergic asthma are similar to those observed with allergic asthma, some differences have been described, including a higher expression of RANTES in mucosa and bronchoalveolar lavage fluid, as well as a higher GM-CSF receptor alpha expression. "
04/01/2002 - "Taken together, our findings demonstrate that the common beta(c) of IL-3, IL-5, and GM-CSF receptors is involved in the eosinophil influx and airway hyperresponsiveness that follow OVA challenge and underscore the potential utility of a topical antisense approach targeting beta(c) for the treatment of asthma."
03/15/2008 - "Taken together, these results provide novel mechanistic insights defining the interaction between ICAM-1 and the GM-CSF receptor and highlight the importance of targeting ICAM-1 and GM-CSF/IL-5/IL-3 receptor systems as a therapeutic strategy to counter eosinophilia in asthma."
|1.||Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF)
|2.||Messenger RNA (mRNA)
|3.||Interleukin-5 (Interleukin 5)
|4.||Interleukin-3 (Interleukin 3)
|5.||Granulocyte-Macrophage Colony-Stimulating Factor Receptors (GM-CSF Receptor)
|8.||Interleukin-8 (Interleukin 8)
|9.||Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
|10.||Proteins (Proteins, Gene)
|1.||Transplantation (Transplant Recipients)