Granulocyte-Macrophage Colony-Stimulating Factor Receptors (GM-CSF Receptor)

Receptors that bind and internalize the granulocyte-macrophage stimulating factor. Their MW is believed to be 84 kD. The most mature myelomonocytic cells, specifically human neutrophils, macrophages, and eosinophils, express the highest number of affinity receptors for this growth factor.

Also Known As:

GM-CSF Receptor; Receptors, Granulocyte-Macrophage Colony-Stimulating Factor; CD116 Antigen; Receptor, Granulocyte-Macrophage Colony-Stimulating Factor; Receptors, GM-CSF; Antigen, CD116; GM CSF Receptor; GM CSF Receptors; Receptor, GM-CSF; Receptor, Granulocyte Macrophage Colony Stimulating Factor; Receptors, GM CSF; Receptors, Granulocyte Macrophage Colony Stimulating Factor; Antigens, CD116; CD116 Antigens; GM-CSF Receptors

Networked: 140 relevant articles (1 outcomes, 11 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Suzuki, Takuji: 7 articles (01/2022 - 04/2008)
2.	Moritz, Thomas: 7 articles (01/2020 - 04/2008)
3.	Trapnell, Bruce C: 6 articles (01/2022 - 11/2010)
4.	Sleeman, Matthew A: 6 articles (11/2021 - 09/2011)
5.	Lachmann, Nico: 5 articles (01/2020 - 01/2014)
6.	Carey, Brenna: 4 articles (06/2021 - 10/2014)
7.	Arumugam, Paritha: 3 articles (01/2022 - 10/2014)
8.	Chalk, Claudia: 3 articles (01/2022 - 11/2010)
9.	Whitsett, Jeffrey A: 3 articles (01/2021 - 01/2010)
10.	Hansen, Gesine: 3 articles (01/2020 - 01/2014)

Related Diseases

1.	Colitis 03/01/2010 - "Importantly, transfer of splenic GM-CSF-induced CD11b(+) myeloid cells into DSS-exposed mice improved colitis, and lethally irradiated GM-CSF receptor-deficient mice reconstituted with wildtype bone marrow cells were protected from DSS-induced colitis upon GM-CSF therapy. "
2.	Rheumatoid Arthritis 10/01/2015 - "Preclinical characterisation of the GM-CSF receptor as a therapeutic target in rheumatoid arthritis." 11/13/1993 - "Expression of GM-CSF receptor in rheumatoid arthritis." 10/01/2015 - "Previous work has suggested that the granulocyte macrophage colony stimulating factor (GM-CSF)-GM-CSF receptor α axis (GM-CSFRα) may provide a new therapeutic target for the treatment of rheumatoid arthritis (RA). " 01/01/2013 - "Protein engineering and preclinical development of a GM-CSF receptor antibody for the treatment of rheumatoid arthritis." 12/01/2012 - "Mavrilimumab, a human monoclonal GM-CSF receptor-α antibody for the management of rheumatoid arthritis: a novel approach to therapy."
3.	Neoplasms (Cancer) 06/01/1990 - "GM-CSF receptors distributed on these human tumor cells were low affinity types with an equilibrium dissociation constant of 1.5-10.0 nM. Cross-linking studies revealed that the molecular weights of the low affinity GM-CSF receptors were 65-85 kilodaltons. " 01/01/2013 - "Unexpectedly, an immune-independent antitumor effect was observed that depended on the ectopic expression of GM-CSF receptor subunits by tumors. " 09/01/2004 - "The four kinds of cancer cell lines had prominent GM-CSF receptor alpha subunit expression. " 01/01/1993 - "Thus gross structural lesions in the genes encoding the GM-CSF receptor alpha and beta chains appear to be infrequent in hemopoietic neoplasms." 03/01/1989 - "Nonhematopoietic tumor cells express functional GM-CSF receptors."
4.	Inflammation (Inflammations) 01/01/2021 - "Ssu72 regulates alveolar macrophage development and allergic airway inflammation by fine-tuning of GM-CSF receptor signaling." 01/01/2018 - "CFP1-deficient mice were more susceptible to bacterial infection due to the decreased expression of Csf2rα, a subunit of the GM-CSF receptor essential for inflammation and alveolar macrophage development, through the loss of H3K4 modifications in the promoter of the Csf2rα gene. " 01/01/2019 - "Wild-type and GM-CSF receptor α (Csf2ra)-deficient mice reconstituted with Csf2ra-proficient alveolar macrophages were subjected to different models of airway inflammation to evaluate the effect of GM-CSF signaling deficiency on asthmatic inflammation in general and on eosinophils in particular. " 10/01/2016 - "Inflammation resulted in an increasing GM-CSF and GM-CSF-receptor level in the lysate of mesothelial cells. " 09/01/2020 - "Antimalarials, anti-IL6-Anti-IL6 receptor, anti-IL1, anti-GM-CSF receptor and JAK1/2/3 inhibitors, are under investigation in COVID-dedicated clinical trials to control the inflammation raised by SARS-CoV-2 infection. "
5.	Asthma (Bronchial Asthma) 05/01/1997 - "Upregulation of alpha GM-CSF-receptor in nonatopic asthma but not in atopic asthma." 11/01/2014 - "Although many of the immunopathologic features of nonallergic asthma are similar to those observed with allergic asthma, some differences have been described, including a higher expression of RANTES in mucosa and bronchoalveolar lavage fluid, as well as a higher GM-CSF receptor alpha expression. " 01/01/2021 - "Different experimental animal models of chronic asthma were used in combination with alveolar macrophage-reconstitution of global GM-CSF receptor knockout mice as well as cell-type-specific knockout animals to elucidate the role of GM-CSF signaling in chronic airway inflammation. " 05/01/1997 - "This study was carried out to investigate the expression of alpha GM-CSF receptor (alpha GM-CSFr) messenger RNA and protein in the bronchial mucosa of patients with intrinsic or atopic asthma and of control subjects and to correlate the expression of alpha GM-CSFr to the number of EG2+ cells (eosinophils) and CD68+ cells (macrophages) and pulmonary function. " 04/01/2002 - "Taken together, our findings demonstrate that the common beta(c) of IL-3, IL-5, and GM-CSF receptors is involved in the eosinophil influx and airway hyperresponsiveness that follow OVA challenge and underscore the potential utility of a topical antisense approach targeting beta(c) for the treatment of asthma."

Related Drugs and Biologics

1.	Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF)
2.	Monoclonal Antibodies
3.	mavrilimumab
4.	Messenger RNA (mRNA)
5.	Proteins (Proteins, Gene)
6.	Cytokines
7.	Interleukin-5 (Interleukin 5)
8.	Interleukin-1 Receptors (Interleukin 1 Receptor)
9.	Antimalarials (Antimalarial Agents)
10.	Interleukin-3 (Interleukin 3)

Related Therapies and Procedures

1.	Therapeutics
2.	Stem Cell Transplantation
3.	Bone Marrow Transplantation (Transplantation, Bone Marrow)
4.	Transplantation