|1.||Frankel, Arthur E: 6 articles (02/2015 - 01/2004)|
|2.||Frankel, A E: 6 articles (01/2003 - 04/2000)|
|3.||Ramage, J: 5 articles (01/2003 - 04/2000)|
|4.||Kucera, G L: 4 articles (10/2001 - 04/2000)|
|5.||Alexander, R L: 4 articles (10/2001 - 04/2000)|
|6.||Lopez, Angel F: 3 articles (07/2015 - 01/2013)|
|7.||McCubrey, J A: 3 articles (01/2003 - 04/2000)|
|8.||Kiser, M: 3 articles (05/2001 - 04/2000)|
|9.||Miller, M S: 3 articles (05/2001 - 04/2000)|
|10.||Busfield, Samantha J: 2 articles (07/2015 - 07/2014)|
05/01/1995 - "Therefore, the inhibitor had a substantially improved affinity for the IL-3 receptor on these leukemia cells. "
07/01/2015 - "The interleukin-3 receptor α-chain (CD123) is highly expressed on the surface of acute leukemia cells compared with normal hematopoietic stem cells. "
07/01/2014 - "Leukocyte interleukin-3 receptor α (CD123) is regarded as a marker of leukemia stem cells. "
09/01/2011 - "Our aim was to construct and characterize (111)In-nuclear translocation sequence (NLS)-7G3, an Auger electron-emitting radioimmunotherapeutic agent that preferentially recognizes the expression of CD123 (interleukin-3 receptor [IL-3R] α-subchain) in the absence of CD131 (IL-3R β-subchain) displayed by leukemia stem cells. "
10/01/2009 - "We compared the expression of CD123, the alpha chain of the interleukin-3 receptor, on normal B-cell precursors in bone marrow ("hematogones") from 75 specimens and on leukemic blasts in 45 newly diagnosed B-acute lymphoblastic leukemias (B-ALL) cases. "
|2.||Acute Myeloid Leukemia (Acute Myelogenous Leukemia)
02/01/2004 - "Recent studies indicate that abnormalities of the interleukin-3 receptor (IL-3R) are frequently observed in acute myeloid leukemias (AMLs) and may contribute to the proliferative advantage of leukemic blasts. "
11/15/2006 - "The interleukin-3 receptor (IL-3R) subunits are overexpressed on acute myeloid leukemia (AML) blasts compared with normal hematopoietic cells and are thus potential targets for novel therapeutic agents. "
10/01/2006 - "Since high expression levels of p21 and overexpression of the IL-3 receptor have been correlated with poor outcomes in acute myeloid leukemias (AML), differentiation blockade by p21 may be one mechanism that contributes to AML pathogenesis."
05/01/2001 - "This is a unique, reproducible model for in vivo growth of a differentiated human acute myeloid leukemia and may be useful in the assessment of anti-leukemic therapeutics which have human-specific molecular targets such as the interleukin-3 receptor."
01/01/2005 - "In one common type of acute myeloid leukemia, which results in maturation arrest at the myeloid precursor level, there is a mutation of FLT3, a transmembrane tyrosine kinase, which results in constitutive activation of the IL-3 receptor. "
02/01/2015 - "Since blastic plasmacytoid dendritic cell neoplasm cells express high levels of interleukin-3 receptor α chain (IL3-Rα or CD123), antitumor effects of the interleukin-3 receptor-targeted drug SL-401 against blastic plasmacytoid dendritic cell neoplasm were evaluated in vitro and in vivo. "
02/01/2015 - "In vivo and in vitro sensitivity of blastic plasmacytoid dendritic cell neoplasm to SL-401, an interleukin-3 receptor targeted biologic agent."
07/24/2014 - "Dual mechanism of interleukin-3 receptor blockade by an anti-cancer antibody."
07/17/2014 - "Activity of SL-401, a targeted therapy directed to interleukin-3 receptor, in blastic plasmacytoid dendritic cell neoplasm patients."
12/01/2007 - "CD4+/CD56+ hematodermic neoplasm: presentation of 2 cases and review of the concept of an uncommon tumor originated in plasmacytoid dendritic cells expressing CD123 (IL-3 receptor alpha)."
|4.||Asthma (Bronchial Asthma)
09/01/2001 - "To investigate the iufluence of dexamethasone (DM) on expression of interleukin-5 receptor alpha(IL-5R alpha), interleukin-3 receptor alpha (IL-3R alpha), granulocyte-macrophage-colony-stimulating factor receptor alpha(GM-CSFR alpha) and common beta receptor (beta cR) in bronchalveolar lavage fluid (BALF) eosinophils in guinea pig asthma model, and to study the mechanism of promotion effect of steroid on eosinophil apoptosis. "
03/15/2008 - "Taken together, these results provide novel mechanistic insights defining the interaction between ICAM-1 and the GM-CSF receptor and highlight the importance of targeting ICAM-1 and GM-CSF/IL-5/IL-3 receptor systems as a therapeutic strategy to counter eosinophilia in asthma."
05/01/2014 - "Studies using animal models of monocytosis and atherosclerosis such as ApoE(-/-) mice have shown bone marrow (BM) hematopoietic stem and multipotential progenitor cell (HSPC) expansion, associated with increased cell surface expression of the common β subunit of the granulocyte macrophage colony-stimulating factor/interleukin-3 receptor (CBS) on HSPCs. "
|1.||Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF)
|2.||Interleukin-5 Receptors (Interleukin 5 Receptor)
|4.||Granulocyte Colony-Stimulating Factor (G-CSF)
|8.||Apolipoproteins E (ApoE)
|1.||Drug Therapy (Chemotherapy)