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Visna

Demyelinating leukoencephalomyelitis of sheep caused by the VISNA-MAEDI VIRUS. It is similar to but not the same as SCRAPIE.

Also Known As:

Ovine Encephalomyelitis; Encephalomyelitides, Ovine; Ovine Encephalomyelitides; Visnas; Encephalomyelitis, Ovine

Networked: 105 relevant articles (1 outcomes, 5 trials/studies) for this Disease, Comments

Relationship Network

Disease Context: Research Results

Related Diseases

1.	of Sheep Progressive Interstitial Pneumonia (Maedi)
2.	Infection
3.	Pneumonia (Pneumonitis)
4.	Arthritis (Polyarthritis)
5.	Encephalitis (Encephalitis, Rasmussen)

Experts

1.	Peterhans, E: 3 articles (11/2001 - 04/2000)
2.	Zanoni, R: 2 articles (11/2001 - 04/2000)
3.	Wu, Changxin: 1 article (10/2008)
4.	McConnell, Ian: 1 article (10/2008)
5.	Blacklaws, Barbara A: 1 article (10/2008)
6.	Barbezange, Cyril: 1 article (10/2008)
7.	Smerdon, Stephen J: 1 article (07/2008)
8.	Pennell, Simon: 1 article (07/2008)
9.	Manktelow, Emily: 1 article (07/2008)
10.	Kelly, Geoff: 1 article (07/2008)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Visna:

1.	AntigensIBA 06/01/1998 - "In visna-infected sheep a considerable induction of MHC antigens on microglia was observed, which correlated with severity of lesions and was mainly found in or adjacent to inflammatory infiltrates of the white matter. " 06/01/1998 - "Constitutive and visna virus induced expression of class I and II major histocompatibility complex antigens in the central nervous system of sheep and their role in the pathogenesis of visna lesions." 12/01/1992 - "The responding T cell population in this assay was mainly of the CD4+ phenotype, although in some individuals CD8+ T cells were also shown to respond to visna antigen in this system." 11/01/1976 - "However, these comparative studies did not provide any evidence for the role of an autoimmune response, to the two central nervous system antigens tested, in the pathogenesis of visna." 01/01/1969 - "Visna and maedi virus antigen in infected cell cultures studied by the fluorescent antibody technique." Order ALL the reference details at left...
2.	Sodium Dodecyl Sulfate (Sodium Lauryl Sulfate)IBA 10/01/1990 - "We report the efficacy of an anionic detergent, sodium dodecyl sulfate (SDS) for preparing maedi-visna antigens for an indirect enzyme-linked immunosorbent assay (i-ELISA). " Order ALL the reference details at left...
3.	Detergents (Detergent)IBA 10/01/1990 - "We report the efficacy of an anionic detergent, sodium dodecyl sulfate (SDS) for preparing maedi-visna antigens for an indirect enzyme-linked immunosorbent assay (i-ELISA). " Order ALL the reference details at left...
4.	InterferonsIBA 02/01/1990 - "In recent studies of the Lentivirinae subfamily of Retroviridae, an endogenous, immunologically induced interferon was found to restrict the replication of visna in macrophages. " 07/01/1989 - "We have studied the effects of recombinant human alpha A interferon (IFN) on the multiplication of Visna retrovirus in ovine cells. " 12/01/1985 - "Visna viruses induce a unique interferon during interaction between lymphocytes and infected macrophages." 10/01/1991 - "2. the role of lentivirus-induced interferon (LV-IFN) in the pathogenesis of Maedi/Visna. " 05/01/1987 - "Co-cultivation of sheep or goat lymphocytes with macrophages infected with visna or CAE viruses results in production of a unique interferon (LV-IFN). " Order ALL the reference details at left...
5.	Glycoproteins (Glycoprotein)IBA 12/01/2002 - "Although the VISNA envelope (Env) glycoprotein is the main target for virus neutralization, studies on the role of this protein in virus infection are limited. " 07/17/2001 - "Remarkably, despite less than 23% sequence identity, the ectodomains in Visna and HIV-1 envelope glycoproteins show detailed structural conservation, especially within the area of a hydrophobic pocket in the central coiled coil currently being targeted for the development of new anti-HIV drugs." 01/01/1997 - "Thus, the recombinant visna surface envelope glycoprotein is capable of inducing both neutralizing and fusion-blocking antibodies. " 01/01/2004 - "A single-chain antibody fragments (scFv) was developed directed against transmembrane envelope glycoprotein gp46 of the virus maedi-visna, by the application of the antibody phage display library. " 06/01/1985 - "Antigenic cross-reactivity between caprine arthritis-encephalitis, visna and progressive pneumonia viruses involves all virion-associated proteins and glycoproteins." Order ALL the reference details at left...
6.	Carbon MonoxideIBA 11/01/1989 - "Two members of each group, visna 1514 and its antigenic variant LV1-1 in the first group and CAEV/CO and S93, a field isolate virus from a local arthritic sheep, in the second group, were examined in the present study in competitive-binding studies in fibroblast and macrophage cell cultures. " 06/01/1971 - "Visna or PPV could be "rescued" from all transformed lines by co-cultivation with normal sheep testis cells. " 05/01/1987 - "Co-cultivation of sheep or goat lymphocytes with macrophages infected with visna or CAE viruses results in production of a unique interferon (LV-IFN). " Order ALL the reference details at left...
7.	Transcription Factor AP-1 (Transcription Factor AP 1)IBA 11/01/1993 - "Because the Tat product enhanced the transcription of the visna LTR via the AP-1 site, we asked whether this viral factor could regulate the expression of cellular factors involved in one of the cellular activation pathways. " 11/01/1993 - "We analyzed a series of visna LTR plasmids containing either the AP-1 or the AP-4 or both target responsive sequences for visna Tat transactivation. " 08/15/2006 - "Previous studies with the closely related maedi visna lentivirus have indicated that viral transcription is dependent upon the AP-1 transcription factor. " 11/01/1993 - "Furthermore, the absence of this AP-4 sequence dramatically decreased the additive effect observed when U937 cells were both treated by phorbol ester and expressed the tat gene product, suggesting a high interdependence of the AP-1 and AP-4 sequences for the regulation of the transcription driven by the visna LTR. " Order ALL the reference details at left...
8.	Viral AntigensIBA 01/01/1989 - "Expression of viral antigens in the central nervous system of visna-infected sheep: an immunohistochemical study on experimental visna induced by virus strains of increased neurovirulence." 03/01/1985 - "With a new strain of virus that causes a rapid form of visna in Icelandic sheep, viral antigens were demonstrated in cells in the inflammatory lesions. " Order ALL the reference details at left...
9.	Transcription Factors (Transcription Factor)IBA 08/15/2006 - "Previous studies with the closely related maedi visna lentivirus have indicated that viral transcription is dependent upon the AP-1 transcription factor. " Order ALL the reference details at left...
10.	AntibodiesIBA 12/01/1996 - "Since the MVV peptide was not recognised by antibodies or T lymphocytes from MVV-infected and encephalic sheep, it was concluded that epitope mimicry of this 21.5 kDa MBP peptide by the similar MVV pol peptide was not contributing to the immunopathogensis of Visna. " 12/01/1971 - "It was found that the PHA test was 10 to 100 times more sensitive than the CF test in detecting visna antibodies in rabbits. " 05/01/1995 - "[Serologic investigations on the occurrence of Maedi-Visna antibodies in game ruminants]" 11/01/1990 - "In a period of one year blood samples of 374 sheep of Lower Austrian flocks were examined in intervals of two months for antibodies against Maedi-Visna (MV). " 02/01/1990 - "883 sheep from 68 flocks were tested for the prevalence of antibodies against Maedi/Visna-(M/V)virus. " Order ALL the reference details at left...

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