An acidic glycoprotein of MW 23 kDa with internal disulfide bonds. The protein is produced in response to a number of inflammatory mediators by mesenchymal cells present in the hemopoietic environment and at peripheral sites of inflammation. GM-CSF is able to stimulate the production of neutrophilic granulocytes, macrophages, and mixed granulocyte-macrophage colonies from bone marrow cells and can stimulate the formation of eosinophil colonies from fetal liver progenitor cells. GM-CSF can also stimulate some functional activities in mature granulocytes and macrophages.
Also Known As:
GM-CSF; CSF-2; Colony Stimulating Factor, Granulocyte Macrophage; TC-GM-CSF; Tumor-Cell Human GM Colony-Stimulating Factor; Cell-Stimulating Factor, Histamine-Producing; Granulocyte Macrophage Colony Stimulating Factor; Histamine Producing Cell Stimulating Factor; Tumor Cell Human GM Colony Stimulating Factor; CSF-GM; Colony-Stimulating Factor, Granulocyte-Macrophage; Histamine-Producing Cell-Stimulating Factor; Colony-stimulating factor 2