Retinoblastoma Protein

Product of the retinoblastoma tumor suppressor gene. It is a nuclear phosphoprotein hypothesized to normally act as an inhibitor of cell proliferation. Rb protein is absent in retinoblastoma cell lines. It also has been shown to form complexes with the adenovirus E1A protein, the SV40 T antigen, and the human papilloma virus E7 protein.

Also Known As:

Networked: 1707 relevant articles (21 outcomes, 154 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Dick, Frederick A: 9 articles (01/2020 - 07/2010)
2.	Lees, Jacqueline A: 8 articles (05/2013 - 04/2002)
3.	Cobrinik, David: 7 articles (01/2019 - 08/2002)
4.	Hinds, Philip W: 7 articles (01/2018 - 03/2003)
5.	Sakai, Toshiyuki: 7 articles (01/2018 - 05/2007)
6.	O'Dwyer, Peter J: 6 articles (01/2020 - 01/2012)
7.	Sherr, Charles J: 6 articles (01/2020 - 08/2002)
8.	Bronson, Roderick T: 6 articles (12/2019 - 04/2002)
9.	Slack, Ruth S: 6 articles (01/2017 - 02/2002)
10.	Zhang, Peng: 6 articles (01/2015 - 01/2012)

Related Diseases

1.	Retinoblastoma (Glioblastoma, Retinal) 01/01/2023 - "The killing is by apoptosis and appears to act by a route other than the canonical downstream target of p16 and CDK4, the retinoblastoma (RB) protein family, as it is also effective in HeLa cells and a melanocyte line expressing HPV E7 oncogenes, which both lack any active RB. " 09/01/2004 - "To develop and use improved Semliki Forest vectors (SFVs) for functional and structural analyses of the retinoblastoma protein (RB) in developing retina and retinoblastoma cells. " 09/01/2004 - "Retinoblastoma protein purification and transduction of retina and retinoblastoma cells using improved alphavirus vectors." 01/01/2020 - "E2f5 was initially characterized as a transcriptional repressor in cell proliferation studies through its interaction with the Retinoblastoma (Rb) protein for inhibition of target gene transcription. " 03/05/2004 - "Previous studies have suggested that tTG may modulate retinoblastoma (Rb) protein, an important suppressor of apoptosis. "
2.	Neoplasms (Cancer) 10/23/2022 - "Our study identifies RB protein as a bona fide intrinsic inhibitor of BRD4 and demonstrates that RB inactivation confers resistance to small molecule BET inhibitors, thereby revealing a regulatory hub that converges RB upstream signaling onto BRD4 functions in diseases such as cancer." 01/17/2020 - "The retinoblastoma protein (pRb) is a tumor suppressor that canonically regulates cell cycle progression; however, recent studies have highlighted a functional role for pRb in controlling cellular metabolism. " 01/01/2016 - "Both the direct and indirect targets were also observed in a human tumor xenograft study using the COLO-205 cell line in which phosphorylation of the retinoblastoma protein was tracked as the pharmacodyanamic marker. " 09/01/2014 - "Our previous studies indicate that the NRP/B-BTB/POZ domain is involved in the dimerization of NRP/B and in a complex formation with the tumor suppressor, retinoblastoma protein. " 01/01/2014 - "LAP2α has been reported to regulate cell proliferation by affecting the activity of retinoblastoma protein in tissue progenitor cells and numerous studies showed upregulation of LAP2α in cancer. "
3.	Breast Neoplasms (Breast Cancer) 01/01/2022 - "In this study, we investigated the effects of HER2 on CDK4/6 activity by assessing the level of downstream phosphorylated retinoblastoma protein (pRb) in HER2-positive breast cancer (HER2 positivity is defined by immunohistochemical study or FISH, regardless of ER status) to determine if these cases may be responsive to CDK4/6 inhibitors. " 04/01/2013 - "There are only a few published studies on the expression and localization of RB protein in the cells of HER2-positive breast cancer. " 08/17/2000 - "In this study we analysed the growth suppressive effect of HPR on human breast cancer cell lines in vitro and the role of the retinoblastoma protein (pRb) in this response. " 04/01/1994 - "Expression of retinoblastoma protein in human breast cancer: an immunohistochemical study." 10/01/2022 - "We found that a small-molecule inhibitor of ERK5 suppressed the phosphorylation of the retinoblastoma protein (RB) in HER2 positive breast cancer cells. "
4.	Urinary Bladder Neoplasms (Bladder Cancer) 05/01/2010 - "Identification of molecular prognosticators that might be helpful in discriminating between responders and nonresponders to BCG treatment is therefore of major clinical importance; thus we focused on the cell-cycle related retinoblastoma protein (pRB), which had been already investigated in bladder cancer. " 07/21/2003 - "The objective of the study was to investigate the predictive value of various clinical, biochemical, and histopathological parameters, with special emphasis on the expression of the retinoblastoma protein (pRB), on the radiation response in bladder cancer. " 02/04/1999 - "Recent studies have shown that patients whose bladder cancer exhibit overexpression of RB protein as measured by immunohistochemical analysis do equally poorly as those with loss of RB function. " 08/19/1992 - "This study demonstrates that altered patterns of Rb protein expression may be an important prognostic variable in patients presenting with invasive bladder cancer." 01/01/2015 - "There are many patients with bladder cancer with confirmed absence of retinoblastoma protein, which is responsible of holding on the process of coming up the cells with mutation into synthesis, where the replication process undergoes. "
5.	Osteosarcoma (Osteogenic Sarcoma) 10/01/1997 - "We tested the efficacy of our system by expressing the wt or mutant p16 genes in the osteosarcoma cell line, U20S, which lacks p16 and retains functional retinoblastoma protein (pRb). " 11/11/2010 - "A role for the retinoblastoma protein as a regulator of mouse osteoblast cell adhesion: implications for osteogenesis and osteosarcoma formation." 08/01/2007 - "Different effects of ribosome biogenesis inhibition on cell proliferation in retinoblastoma protein- and p53-deficient and proficient human osteosarcoma cell lines." 11/01/2006 - "The retinoblastoma protein in osteoblast differentiation and osteosarcoma." 08/01/2001 - "To understand why the retinoblastoma protein (pRb) is specifically targeted in osteosarcoma, we studied its function in osteogenesis. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Cyclin D1
3.	palbociclib
4.	Cyclin D3
5.	Messenger RNA (mRNA)
6.	Cyclin-Dependent Kinases (cdk Proteins)
7.	Antibodies
8.	Cyclin D
9.	DNA (Deoxyribonucleic Acid)
10.	erucylphospho- N,N,N- trimethylpropylammonium

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Radiotherapy
3.	Intravesical Administration
4.	Chemoradiotherapy
5.	Transurethral Resection of Bladder