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Retinoblastoma Protein

Product of the retinoblastoma tumor suppressor gene. It is a nuclear phosphoprotein hypothesized to normally act as an inhibitor of cell proliferation. Rb protein is absent in retinoblastoma cell lines. It also has been shown to form complexes with the adenovirus E1A protein, the SV40 T antigen, and the human papilloma virus E7 protein.
Also Known As:
Rb Gene Product; Rb1 Gene Product; Retinoblastoma Nuclear Phosphoprotein p105 Rb; p105 Rb Protein; Rb Protein; Retinoblastoma Nuclear Phosphoprotein p105-Rb; p105-Rb Protein
Networked: 1348 relevant articles (12 outcomes, 126 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Lees, Jacqueline A: 8 articles (05/2013 - 04/2002)
2. Hinds, Philip W: 6 articles (05/2010 - 03/2003)
3. Sakai, Toshiyuki: 5 articles (01/2015 - 05/2007)
4. Bronson, Roderick T: 5 articles (08/2011 - 04/2002)
5. Slack, Ruth S: 5 articles (07/2007 - 02/2002)
6. Mignotte, Bernard: 4 articles (09/2015 - 05/2005)
7. Blanck, George: 4 articles (12/2014 - 02/2006)
8. Zhang, Peng: 4 articles (09/2014 - 01/2012)
9. Dong, Shang-Wen: 4 articles (09/2014 - 01/2012)
10. Wang, Yuan-Guo: 4 articles (09/2014 - 01/2012)

Related Diseases

1. Retinoblastoma (Glioblastoma, Retinal)
2. Neoplasms (Cancer)
3. Breast Neoplasms (Breast Cancer)
4. Urinary Bladder Neoplasms (Bladder Cancer)
5. Osteosarcoma (Osteogenic Sarcoma)

Related Drugs and Biologics

1. Cyclin D1
2. Proteins (Proteins, Gene)
3. Cyclin D3
4. Messenger RNA (mRNA)
5. Cyclin D
6. erucylphospho- N,N,N- trimethylpropylammonium
7. Hormones
8. Glutathione S-Transferase pi
9. Multidrug Resistance-Associated Proteins
10. P-Glycoprotein

Related Therapies and Procedures

1. Drug Therapy (Chemotherapy)
2. Heterologous Transplantation (Xenotransplantation)
3. Intravesical Administration
4. Cystectomy
5. Lasers (Laser)