|1.||Oren, Moshe: 4 articles (08/2007 - 09/2002)|
|2.||Selivanova, Galina: 4 articles (01/2007 - 02/2002)|
|3.||Kelsey, Karl T: 4 articles (11/2005 - 07/2005)|
|4.||Lu, Wuyuan: 3 articles (11/2015 - 04/2010)|
|5.||Kaul, Sunil C: 3 articles (07/2015 - 01/2009)|
|6.||Wadhwa, Renu: 3 articles (07/2015 - 01/2009)|
|7.||Yamada, Tohru: 3 articles (01/2014 - 10/2002)|
|8.||Rotter, Varda: 3 articles (01/2013 - 11/2004)|
|9.||Li, Chong: 3 articles (04/2012 - 04/2010)|
|10.||Kaiser, Peter: 3 articles (10/2011 - 09/2009)|
09/01/1999 - "The p53 tumor suppressor protein is a pivotal molecule in the protection against carcinogenesis and is inactivated in a plethora of human neoplasms, p53 prevents the accumulation of genomic alterations by inducing cell-cycle arrest or programmed cell death in response to genotoxic signals such as DNA damage and stress. "
06/01/1998 - "The tumor suppressor protein p53 plays a pivotal role in protection against the development of cancer and is inactivated in many human malignancies. "
07/01/2008 - "The present study was designed to investigate the expression pattern of KAI-1 in the normal endometrium and uterine tumors and to correlate it with the expression of tumor suppressor protein p53. "
10/04/2001 - "The p53 tumor suppressor protein is mutated in more than 50% of all human cancers, which makes the study of its functions and activities critical for the understanding and management of cancer. "
12/01/2015 - "The p53 tumor suppressor protein plays a critical role in cellular stress and cancer prevention. "
08/15/2004 - "Here, we evaluated the conditionally replicative adenovirus AdDelta24 and its recently developed derivative AdDelta24-p53, which expresses functional p53 tumor suppressor protein while replicating in cancer cells, for treatment of malignant glioma. "
11/01/1996 - "High variability of the oncoprotein p53 immunoreactivity is characteristic of glioblastomas this suggesting genotypic polymorphism of gliomas of high grade malignancy. "
12/15/2003 - "Involvement of tumor suppressor protein p53 and p38 MAPK in caffeic acid phenethyl ester-induced apoptosis of C6 glioma cells."
08/15/2014 - "Action mechanism studies indicated that the enhanced efficacy of the multifunctional targeting drugs-loaded liposomes could be due to the following aspects: evading the rapid elimination from blood circulation; crossing the BBB effectively; improving drug uptake by glioma cells and GSCs; down-regulating the overexpressed ABC transporters; inducing apoptosis of GSCs via up-regulating apoptotic receptor/ligand (Fas/Fasl), activating apoptotic enzymes (caspases 8, 9 and 3), activating pro-apoptotic proteins (Bax and Bok), activating tumor suppressor protein (P53) and suppressing anti-apoptotic proteins (Bcl-2 and Mcl-1). "
|3.||T-Cell Lymphoma (Lymphoma, T Cell)
08/03/2010 - "This synthetic lethal interaction is attributable to inhibition of aurora-B kinase, with consequent disabling of the chromosomal passenger protein complex (CPPC) and ensuing DNA replication in the absence of cell division; executed by sequential apoptosis and autophagy; not reliant on the tumor suppressor protein p53; and effective against mouse models for B-cell and T-cell lymphomas initiated by transgenes of MYC. "
|4.||Parkinson Disease (Parkinson's Disease)
02/09/2004 - "We conducted the present study to evaluate the frequency and prognostic importance on long-term survival of TP53 mutations and TP53 protein accumulation in a cohort of 178 patients with early-stage ovarian carcinomas. "
06/01/1993 - "The expression of p53 antigen in primary malignant epithelial tumors of the liver: an immunohistochemical study."
12/28/2014 - "To examine the effect of tumor suppressor protein p53 on the antitumor activity of 2- methoxyestradiol (2-MeO-E2), 2-MeO-E2-induced cell cycle changes and apoptotic events were compared between the human colon carcinoma cell lines HCT116 (p53(+/+)) and HCT116 (p53(-/-)). "
12/01/2013 - "From these data, we argue that tumoral FOXP3 has a potential oncogenic function in conjunction with the p53 tumor suppressor protein and infiltrated Tregs in human breast carcinomas."
12/01/2013 - "Tumoral FOXP3 has potential oncogenic function in conjunction with the p53 tumor suppressor protein and infiltrated Tregs in human breast carcinomas."
|2.||Apoptosis Regulatory Proteins
|4.||ATP-Binding Cassette Transporters (ABC Transporters)
|8.||aurora kinase (aurora A kinase)
|3.||Drug Therapy (Chemotherapy)
|4.||Angioplasty (Angioplasty, Transluminal)