Ichthyosis Vulgaris (Dominant Ichthyosis Vulgaris)

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96 relevant articles (4 outcomes, 7 trials/studies) found for this Disease

Description: Most common form of ICHTHYOSIS characterized by prominent scaling especially on the exterior surfaces of the extremities. It is inherited as an autosomal dominant trait.

Also Known As:

Dominant Ichthyosis Vulgaris; Ichthyosis Vulgaris, Dominant

Relationship Network

Disease Context: Research Results

Congenital, Hereditary, and Neonatal Diseases and Abnormalities: 420

Congenital Abnormalities: 9308

Skin Abnormalities: 74

Ichthyosis: 495

Ichthyosis Vulgaris: 96

Inborn Genetic Diseases: 548

Genetic Skin Diseases: 10

Ichthyosis Vulgaris: 96

Skin and Connective Tissue Diseases

Skin Diseases: 5932

Keratosis: 1108

Ichthyosis: 495

Ichthyosis Vulgaris: 96

Skin Abnormalities: 74

Ichthyosis: 495

Ichthyosis Vulgaris: 96

Genetic Skin Diseases: 10

Ichthyosis Vulgaris: 96

Related Diseases

1.	X-Linked Ichthyosis (Ichthyosis, X Linked)
2.	Psoriasis (Pustulosis Palmaris et Plantaris)
3.	Atopic Dermatitis (Atopic Eczema)
4.	Ichthyosis (Xeroderma)
5.	Lichen Planus (Lichen Ruber Planus)
48 Diseases and 48 more articles analyzed in the Research Interface, order at left...

Experts

1.	Sandilands, Aileen: 7 articles (07/2008 - 03/2006)
2.	McLean, W H Irwin: 7 articles (07/2008 - 03/2006)
3.	Evans, Alan T: 5 articles (07/2008 - 03/2006)
4.	Liao, Haihui: 4 articles (05/2007 - 03/2006)
5.	Smith, Frances J D: 4 articles (05/2007 - 03/2006)
6.	Palmer, Colin N A: 3 articles (06/2008 - 02/2007)
7.	Irvine, Alan D: 3 articles (05/2007 - 03/2006)
8.	Zhao, Yiwei: 3 articles (05/2007 - 03/2006)
9.	Terron-Kwiatkowski, Ana: 3 articles (05/2007 - 03/2006)
10.	Akiyama, Masashi: 2 articles (06/2008 - 02/2007)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Ichthyosis Vulgaris:

1.	1 alpha,24-dihydroxyvitamin D3 (Tacalcitol)IBA 01/01/2001 - "OBJECTIVE: The object of the study was to assess the clinical efficacy of topical tacalcitol against ichthyoses with retentive hyperkeratosis; X-linked ichthyosis (XLI), ichthyosis vulgaris (IV), and acquired ichthyosis (AI)" Get all the results and reference details, order at left...
2.	Urea (Carbamide)FDA LinkGeneric 01/01/1989 - "Preparations containing urea were found to be effective in the treatment of ichthyosis vulgaris and so we were encouraged to test their use in other dry skin conditions" Get all the results and reference details, order at left...
3.	Calcitriol (Calcijex)FDA LinkGeneric 01/01/1991 - "The present work compared the clinical efficacy of topically applied 1 alpha,25-dihydroxyvitamin D3 (1 alpha,25-(OH)2D3) in 16 cases with psoriasis vulgaris, 5 with ichthyosis vulgaris and 8 with X-linked ichthyosis" Get all the results and reference details, order at left...
4.	filaggrinIBA 10/01/2008 - "Unique and recurrent mutations in the filaggrin gene in singaporean chinese patients with ichthyosis vulgaris." 07/01/2008 - "Unique and recurrent mutations in the filaggrin gene in Singaporean Chinese patients with ichthyosis vulgaris." 09/01/2007 - "Two loss-of-function mutations in the filaggrin (FLG) gene, R501X and 2282del4, were identified as causative for ichthyosis vulgaris in 15 affected European families, and the mode of inheritance was found to be semidominant" 02/01/2007 - "Filaggrin mutations p.R501X and c.2282del4 in ichthyosis vulgaris." 08/01/2006 - "Mutations in the filament aggregating protein (filaggrin) gene have recently been identified as the cause of the common genetic skin disorder ichthyosis vulgaris (IV), the most prevalent inherited disorder of keratinization" Get all the results and reference details, order at left...
5.	keratohyalinIBA 01/01/1976 - "It has been suggested that ultrastructural studies of keratohyalin granules in the granular layer of the skin can clearly distinguish the dominant type from the X-linked recessive type of ichthyosis vulgaris" 08/01/2002 - "Absence of the granular layer and keratohyalin define a morphologically distinct subset of individuals with ichthyosis vulgaris." 01/13/1995 - "Ichthyosis vulgaris is an autosomal dominant disorder of keratinization characterized by mild hyperkeratosis and reduced or absent keratohyalin granules in the epidermis" 01/01/1976 - "This suggested a reduced synthesis of a normal keratohyalin, different from the synthesis of an abnormal few spongy keratohyaline in autosomal dominant ichthyosis vulgaris." 07/01/1983 - "Such structural abnormalities concern keratohyalin in autosomal-dominant ichthyosis vulgaris, the tonofilament system in hystrix-like ichthyoses, and the anchoring fibrils in dominant dystrophic epidermolyses" Get all the results and reference details, order at left...
6.	Proteins (Proteins, Gene)IBA 08/01/1994 - "Biochemical studies in patients with ichthyosis vulgaris reveal that the proteins profilaggrin and filaggrin are reduced or absent" 03/01/1993 - "Both cellular and intercellular proteins also participate in normal desquamation, and protein abnormalities may provoke abnormal scaling (such as filaggrin in ichthyosis vulgaris)" 03/01/1985 - "We have demonstrated that the structural proteins, profilaggrin and filaggrin, are reduced or absent in 5 patients from 2 pedigrees with ichthyosis vulgaris" 11/01/1994 - "Finally, the keratohyalin abnormality in ichthyosis vulgaris was the clue for the identification of a filaggrin deficiency, at the same time giving evidence to the heterogeneity of keratohyalin proteins." 01/01/2008 - "The following issues were depicted: four AD subforms found in European population but not in Japanese patients: infancy, childhood, adolescence and adulthood; early onset and late onset; with genetic variant analysis revealing each of the overlapping gene loci of AD and asthma; with polymorphism in the filaggrin gene in ichthyosis vulgaris and AD (loss of function variants R 510x and 288 delta 4 in FFG gene in the epidermal biophysical barrier impairment; percutaneous sensitization in AD; role of staphylococcal aureus in IgE sensitization; AD as an autoimmune disease; role of gene-gene and gene-environment interaction in the natural history of AD; and environment allergens and autoallergy in AD (sensitization to self proteins) in nonatopic AD" Get all the results and reference details, order at left...
7.	Vitamin A (Retinol)FDA Link 10/01/1985 - "Vitamin A in skin and serum--studies of acne vulgaris, atopic dermatitis, ichthyosis vulgaris and lichen planus." 12/01/1979 - "Retinol-binding protein in serum and epidermis of patients with ichthyosis vulgaris." 10/01/1985 - "The concentrations of vitamin A and total carotenoids were measured in serum and skin of 61 patients with acne vulgaris, atopic dermatitis, ichthyosis vulgaris or lichen planus, and compared with those in 37 healthy subjects" Get all the results and reference details, order at left...
8.	Isotretinoin (Accutane)FDA LinkGeneric 01/01/1993 - "In a bilaterally paired double-blind comparison study, a cream containing 0.1% 13-cis-retinoic acid (13-cis-RA) and cream base only were applied over 4 weeks in seven patients with non-erythrodermic lamellar ichthyosis (NELI), two patients with Darier's disease and one patient with autosomal dominant ichthyosis vulgaris (ADIV)" Get all the results and reference details, order at left...
9.	hexyl nicotinateIBA 11/01/1993 - "In this study, we characterized the stratum corneum barrier function in 39 patients with various keratinization disorders (autosomal dominant ichthyosis vulgaris [ADI] [n = 7], X-linked recessive ichthyosis [XRI] [n = 6], autosomal recessive congenital ichthyosis [CI] [n = 10], dyskeratosis follicularis [Darier's disease; DD] [n = 8], erythrokeratoderma variabilis [EKV] [n = 8]), and 21 healthy volunteers, using two non-invasive methods: transepidermal water loss (TEWL) measuring outward transport of water through the skin by evaporimetry, and the vascular response to hexyl nicotinate (HN) penetration into the skin as determined by laser-Doppler flowmetry" Get all the results and reference details, order at left...
10.	Steryl-Sulfatase (Steroid Sulfatase)IBA 01/01/1982 - "Elevated levels of arylsulfatase C activity in cultured skin fibroblasts of patients with autosomal dominant ichthyosis vulgaris." 10/01/1978 - "In the skin of 9 other unrelated (adult) patients with proved X-linked inherited ichthyosis vulgaris, arylsulphatase C activity was deficient" 12/01/1988 - "Thirty cases of X-linked ichthyosis (XLI) and 32 cases of ichthyosis vulgaris (IV) were diagnosed by measuring the steroid sulphatase activity of peripheral blood lymphocytes or the electrophoretic mobility of serum LDL or both" 04/01/1985 - "Steroid sulphatase deficiency in patients initially diagnosed as ichthyosis vulgaris or recessive X-linked ichthyosis." 04/01/1985 - "Twenty-one patients with ichthyosis were classified as either ichthyosis vulgaris (IV) (five cases) or recessive X-linked ichthyosis (RXLI) (sixteen cases) by using a steroid sulphatase assay of plantar callus and peripheral leukocytes" Get all the results and reference details, order at left...
60 Drugs and Important Bio-Agents and 93 more articles analyzed in the Research Interface, order at left...

Therapies and Procedures

1.	Hypnosis (Mesmerism) 03/01/2000 - "RESULTS: A wide spectrum of dermatologic disorders may be improved or cured using hypnosis as an alternative or complementary therapy, including acne excoriée, alopecia areata, atopic dermatitis, congenital ichthyosiform erythroderma, dyshidrotic dermatitis, erythromelalgia, furuncles, glossodynia, herpes simplex, hyperhidrosis, ichthyosis vulgaris, lichen planus, neurodermatitis, nummular dermatitis, postherpetic neuralgia, pruritus, psoriasis, rosacea, trichotillomania, urticaria, verruca vulgaris, and vitiligo" Get all the results and reference details, order at left...
2.	Compression Stockings 01/01/1951 - "Ichthyosis vulgaris serpentina without involvement of the genicular region formerly covered by an elastic stocking.]" Get all the results and reference details, order at left...
3.	Transplants (Transplant) 01/01/1989 - "In ichthyosis vulgaris CD36 was also expressed in dendritic cells of the basal layer and in a patient with a graft versus host reaction it was recognized both on scattered keratinocytes and on dendritic cells in the epidermis" Get all the results and reference details, order at left...
3 Therapies and Procedures and 3 more articles analyzed in the Research Interface, order at left...

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