Oligohydramnios

A condition of abnormally low AMNIOTIC FLUID volume. Principal causes include malformations of fetal URINARY TRACT; FETAL GROWTH RETARDATION; GESTATIONAL HYPERTENSION; nicotine poisoning; and PROLONGED PREGNANCY.

Networked: 661 relevant articles (32 outcomes, 63 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Fetal Distress
2.	Preterm Premature Rupture of the Membranes
3.	Acidosis
4.	Fetal Growth Retardation (Intrauterine Growth Retardation)
5.	Rupture

Experts

1.	Wiznitzer, Arnon: 6 articles (01/2019 - 08/2007)
2.	Magann, Everett F: 6 articles (01/2017 - 04/2007)
3.	Hua, Ying: 5 articles (09/2022 - 06/2013)
4.	Chauhan, Suneet P: 5 articles (11/2020 - 04/2007)
5.	Macharey, Georg: 4 articles (01/2021 - 01/2017)
6.	Chen, Chih-Ping: 4 articles (09/2020 - 12/2013)
7.	Wang, Wayseen: 4 articles (09/2020 - 12/2013)
8.	Sheiner, Eyal: 4 articles (06/2019 - 07/2008)
9.	Sago, Haruhiko: 4 articles (01/2019 - 01/2008)
10.	Yogev, Yariv: 4 articles (12/2014 - 06/2004)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Oligohydramnios:

1.	Nitric Oxide (Nitrogen Monoxide)FDA Link 01/01/2002 - "Inhaled nitric oxide for oligohydramnios-induced pulmonary hypoplasia: a report of two cases and review of the literature." 01/01/2018 - "Inhaled Nitric Oxide in Preterm Neonates with Refractory Hypoxemia Associated to Oligohydramnios." 04/01/2009 - "Inhaled nitric oxide for preterm premature rupture of membranes, oligohydramnios, and pulmonary hypoplasia." 03/01/1995 - "We evaluated the use of inhaled nitric oxide in eight premature infants (520 to 1440 gm, 24 to 31 weeks of gestation) who failed to respond to conventional management and who had prolonged rupture of the membranes and oligohydramnios. " 11/01/1994 - "Inhaled nitric oxide in congenital hypoplasia of the lungs due to diaphragmatic hernia or oligohydramnios."
2.	Dinoprostone (PGE2)FDA Link 07/01/2023 - "Cervical ripening using a dinoprostone vaginal insert is a potentially acceptable method in term pregnancy accompanying with oligohydramnios. " 07/01/2023 - "Using dinoprostone slow release vaginal insert for cervical ripening in term-pregnancy with oligohydramnios." 03/20/2022 - "Term nulliparous women with borderline oligohydramnios have similar successful vaginal delivery rates after induction with dinoprostone or SBC, with their advantages and disadvantages. " 05/01/2014 - "(MCA) in 117 patients (27 associated with oligohydramnios) just before and 6 h after the administration of Dinoprostone. " 01/01/2000 - "Use of prostaglandin E2 for cervical ripening in pregnancies with oligohydramnios."
3.	Surface-Active Agents (Surfactants)IBA 03/01/1988 - "Decreased surfactant level in the lung with oligohydramnios: a morphometric and biochemical study." 12/01/2007 - "These results suggest that the occurrence of hypoplastic lungs induced by oligohydramnios is associated with an immaturity of the surfactant system, especially the expression of the lamellar bodies of type II pneumocytes." 07/01/1993 - "Recognizing PH is important because once it has developed, intrauterine intervention in cases of oligohydramnios and postnatal treatment with surfactant inhalation cannot influence the outcome. " 08/25/2023 - "Preterm premature rupture of membranes, oligohydramnios, resuscitation after birth, low Apgar scores, repeated surfactant administration, persistent pulmonary hypertension of the newborn, and pulmonary hemorrhage were associated with the development of pneumothorax. " 09/01/1994 - "An immunohistochemical study of the expression of surfactant apoprotein in the hypoplastic lung of rabbit fetuses induced by oligohydramnios."
4.	Aquaporin 3IBA 01/01/2016 - "In addition, in hAECs with isolated oligohydramnios, Salvia miltiorrhiza may regulate the expression of aquaporin 3 via the ERK1/2 signal transduction pathway, which provides a novel thread to the improved treatment for isolated oligohydramnios. " 01/01/2016 - "In this study, the aim was to investigate how Salvia miltiorrhiza regulate aquaporin 3 expression in the human amnion epithelial cells (hAECs) with normal amniotic fluid volume or isolated oligohydramnios, whether via extracellular signal regulated kinase1/2 (ERK1/2) signal transduction pathway or not. " 01/01/2013 - "To study the effects of Compound Salvia miltiorrhiza Injection (CSI) on aquaporin 3 (AQP3) expression in human amniotic epithelial cells (hAECs), and to explore its mechanisms for treating oligohydramnios. " 01/01/2017 - "Aquaporin 3 (AQP3) has been shown to be low in the amnion and chorion tissues of patients with oligohydramnios and that S. " 01/01/2016 - "Aquaporin 3 Expression Induced by Salvia Miltiorrhiza via ERK1/2 Signal Pathway in the Primary Human Amnion Epithelium Cells from Isolated Oligohydramnios."
5.	Hemoglobins (Hemoglobin)IBA 12/01/2011 - "Intrauterine exchange transfusion improved hemoglobin parameters, fetal growth, and oligohydramnios. " 06/01/1997 - "In three cases the hemoglobin concentration of the smaller twin with oligohydramnios was lower than the normal mean for gestation, and the hemoglobin difference was more than 5 g/dl in two of these cases. " 04/01/2016 - "Small intertwin placental vascular communications allow transfusion, which results in a hemoglobin difference in the twins in the absence of oligohydramnios or polyhydramnios. " 03/01/2013 - "There is a typical oligohydramnios/polyhydramnios sequence in the TTTS syndrome, whereas TAPS is characterized by large inter-twin hemoglobin difference in the absence of amniotic fluid discordances. " 06/01/1997 - "In the other two cases, the hemoglobin concentration of the four fetuses with coexistent oligohydramnios-polyhydramnios was within the normal range. "
6.	Sildenafil Citrate (Viagra)FDA Link 06/01/2022 - "The Effect of Sildenafil on Pregnancy Outcomes in Pregnant Women With Idiopathic Borderline Oligohydramnios: A Randomized Controlled Trial." 01/01/2017 - "Sildenafil citrate increases amniotic fluid volume in pregnancies complicated by oligohydramnios. " 01/01/2017 - "To compare sildenafil plus hydration with hydration alone in improving the amniotic fluid index and neonatal outcomes in pregnancies complicated by idiopathic oligohydramnios ( amniotic fluid index less than 5 cm without underlying maternal or fetal causes and with normal fetal growth). " 06/01/2022 - "This study was designed to compare the effect of sildenafil plus fluid therapy versus fluid therapy alone on pregnancy outcomes and AFI improvement in pregnant women complicated by idiopathic borderline oligohydramnios. " 06/01/2022 - "Conclusion: The findings showed that sildenafil plus fluid therapy do not improve the pregnancy outcomes in women with isolated borderline oligohydramnios compared to fluid therapy alone."
7.	Saline SolutionIBA 09/01/1993 - "2. Saline solution amnioinfusion was effective in relieving oligohydramnios in all cases. " 05/01/1993 - "This report describes infusion of normal saline into the amniotic sacs of three twin gestations with oligohydramnios. " 08/01/1990 - "Amnioinfusion of 55-500 mL of normal saline in cases of severe oligohydramnios led to a significant rise in pressure (4.7 mmHg, 95% confidence interval 3.5-5.9; P less than .0001). " 07/01/1989 - "To avoid unfavorable effects of oligohydramnios on fetal development and well-being, we infused physiologic saline solution continuously into the amniotic cavity at a flow rate of 10 to 20 ml/hr with a new cervical indwelling catheter (PROM-fence). " 04/01/2000 - "Two fetuses with gastroschisis and severe oligohydramnios were treated antenatally with amnioinfusion of saline solution. "
8.	Dexamethasone (Maxidex)FDA LinkGeneric 10/01/2007 - "The purpose of the present study was to examine the effect of maternal dexamethasone treatment the expression of lamellar body in type II pneumocytes of the fetal rabbit lungs with hypoplasia induced by oligohydramnios using electron microscopy. " 10/01/2007 - "Effect of maternal dexamethasone treatment on the type II pneumocytes in hypoplastic lung by oligohydramnios: an ultrastructural study." 07/24/2021 - "She was diagnosed with preterm labour and given dexamethasone intramuscularly, then an obstetric ultrasound scan was done and it revealed severe oligohydramnios. " 10/01/1996 - "The results suggest that maternal dexamethasone treatment accelerates the functional development of alveolar type II cells in SP-A expression, even in hypoplastic lungs induced by oligohydramnios." 07/01/2004 - "In addition, the first-degree heart block resolved completely after only 2 weeks of dexamethasone treatment, and the heart rhythm remained stable throughout the remainder of the pregnancy despite early discontinuation of therapy due to oligohydramnios."
9.	AcidsIBA 01/01/1991 - "In this study the hypothesis was tested that intrapartum amnioinfusion will relieve cord compression in pregnancies complicated by oligohydramnios and will result in a reduced incidence of fetal intolerance to labor as well as improved fetal acid-base status at delivery. " 02/01/2016 - "Despite the risks of oligohydramnios and intermittent UCO, there is little understanding of the acid/base responses rates of chronically hypoxic fetuses to variable FHR decelerations as might occur during human labor. " 04/01/1991 - "It may also be applied to evaluate fetal acid-base status and rapid karyotyping in fetuses with structural anomalies, intrauterine growth retardation, or oligohydramnios. "
10.	Unsaturated Fatty Acids (Polyunsaturated Fatty Acids)IBA 11/01/2016 - "A randomized controlled study of the efficacy of 4 weeks of supplementation with ω-3 polyunsaturated fatty acids in cases of unexplained oligohydramnios."

Therapies and Procedures

1.	Induced Labor 01/01/2017 - "Neither the AFI nor the SDP is superior in identifying oligohydramnios, but the SDP is a better measurement choice as the use of AFI increases the diagnosis rate of oligohydramnios and labor inductions without an improvement in pregnancy outcomes." 11/01/2011 - "The use of the single deepest pocket compared to the AFI to identify oligohydramnios in at-risk pregnancies seems to be a better choice because the use of the AFI leads to an increase in the diagnosis of oligohydramnios, resulting in more labor inductions and cesarean deliveries without any improvement in peripartum outcomes." 07/16/2008 - "The single deepest vertical pocket measurement in the assessment of amniotic fluid volume during fetal surveillance seems a better choice since the use of the amniotic fluid index increases the rate of diagnosis of oligohydramnios and the rate of induction of labor without improvement in peripartum outcomes. " 01/01/2017 - "Study Design We conducted a secondary analysis of women with oligohydramnios undergoing labor induction in the Consortium on Safe Labor study (2002-2008). " 12/01/2022 - "Isolated oligohydramnios (IO) - oligohydramnios in the absence of maternal or gestational comorbidity is debated as an indication for induction of labor. "
2.	Therapeutics 12/01/1999 - "In utero therapy holds promise for improved outcomes by preventing progressive urinary tract damage and permitting drainage of urine into the amniotic space to minimize the pulmonary sequelae of oligohydramnios. " 07/01/2023 - "A Randomized Trial of Inpatient and Home-Based Maternal Oral Hydration Therapy in Isolated Oligohydramnios and Its Effect on Amniotic Fluid Index and Perinatal Outcome." 01/01/2018 - "Although this report is based on a small number of cases, it follows the directions of other studies that suggest that iNO therapy can benefit preterm neonates, particularly those exposed to oligohydramnios." 02/01/2012 - "The aim of our study was to validate maternal intravenous and oral hydration therapy as a means for improvement of isolated oligohydramnios in the third trimester of pregnancy. " 02/01/2012 - "Maternal hydration therapy improves the quantity of amniotic fluid and the pregnancy outcome in third-trimester isolated oligohydramnios: a controlled randomized institutional trial."
3.	Cesarean Section (Caesarean Section) 01/01/2009 - "In this study, the measure of pregnancy outcomes were mode of delivery, indications of caesarean section, percentage requiring caesarean section for foetal distress, oligohydramnios, meconium stained liquor, small placenta and cord around the neck. " 06/01/1995 - "AFI in this study ranged from 2.8 cm to 22.6 cm. The mean for 41 weeks was 13.52 +/- 4.6 cm and for 42 weeks, 9.93 +/- 4.37 cm. Oligohydramnios was noted in four patients, AFI less than 5.3 cm. Two of these cases developed intrapartum foetal distress and had Caesarean Section. " 01/01/2021 - "To prevent further worsening of pulmonary hypoplasia caused by thoracic compression due to bowel dilation and oligohydramnios, a male neonate was delivered by cesarean section at 32 weeks of gestation. " 09/01/2020 - "At 37 weeks of gestation, a 2560-g female baby was delivered by cesarean section because of oligohydramnios and decreased fetal movements. " 01/01/2020 - "A female infant weighing 953 g was delivered at 27 weeks' gestation by Cesarean section because of oligohydramnios. "
4.	Fetal Version (External Cephalic Version) 01/01/2002 - "Simple maternal hydration appears to increase amniotic fluid volume and may be beneficial in the management of oligohydramnios and prevention of oligohydramnios during labour or prior to external cephalic version. " 01/01/2000 - "Simple maternal hydration appears to increase amniotic fluid volume and may be beneficial in the management of oligohydramnios and prevention of oligohydramnios during labour or prior to external cephalic version. " 06/01/2005 - "When the fetus was found to be breech with oligohydramnios, amnioinfusion was performed to facilitate external cephalic version, and this successful procedure enabled the patient to deliver vaginally." 01/01/2002 - "Oligohydramnios (reduced amniotic fluid) may be responsible for malpresentation problems, umbilical cord compression, concentration of meconium in the liquor, and difficult or failed external cephalic version. " 01/01/2000 - "Oligohydramnios (reduced amniotic fluid) may be responsible for malpresentation problems, umbilical cord compression, concentration of meconium in the liquor, and difficult or failed external cephalic version. "
5.	Transplantation 01/01/2018 - "The aim of this study is to highlight the medical advances in antenatal management of fetal oligohydramnios and pulmonary hypoplasia and to demonstrate that transplantation into a diverted urinary system is safe and leads to good outcomes. " 01/01/2023 - "Adverse birth outcomes such as congenital anomaly, neonatal blood transfusion, and maternal oligohydramnios are associated with a greater risk of transplantation before 14 y of age. "