Simian Acquired Immunodeficiency Syndrome

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75 relevant articles (0 outcomes, 11 trials/studies) found for this Disease

Description: Acquired defect of cellular immunity that occurs naturally in macaques infected with SRV serotypes, experimentally in monkeys inoculated with SRV or MASON-PFIZER MONKEY VIRUS; (MPMV), or in monkeys infected with SIMIAN IMMUNODEFICIENCY VIRUS.

Also Known As:

Simian Acquired Immune Deficiency Syndrome; Simian Acquired Immuno-Deficiency Syndrome; AIDSs, Simian; Simian AIDSs; Simian Acquired Immuno Deficiency Syndrome; AIDS, Simian; SAIDS; Simian AIDS

Disease Context: Research Results

Virus Diseases: 1304

RNA Virus Infections: 36

Retroviridae Infections: 193

Lentivirus Infections: 45

Simian Acquired Immunodeficiency Syndrome: 75

Slow Virus Diseases: 7

Simian Acquired Immunodeficiency Syndrome: 75

Animal Diseases: 109

Primate Diseases: 1

Monkey Diseases: 1

Simian Acquired Immunodeficiency Syndrome: 75

Related Diseases

1.	Simian Acquired Immunodeficiency Syndrome
2.	Acquired Immunodeficiency Syndrome (AIDS)
3.	Infection
4.	Opportunistic Infections (Opportunistic Infection)
5.	Disease Progression
26 Diseases and 31 more articles analyzed in the Research Interface, order at left...

Experts

1.	Chuang, Linda F: 2 articles (01/2005 - 06/2002)
2.	Chuang, Ronald Y: 2 articles (01/2005 - 06/2002)
3.	Suzuki, Shunji: 2 articles (01/2005 - 06/2002)
4.	Doi, Roy H: 2 articles (01/2005 - 06/2002)
5.	Shannon, R: 1 article (01/2008)
6.	Wanke, C: 1 article (01/2008)
7.	Wachtman, L M: 1 article (01/2008)
8.	Gualtieri, L: 1 article (01/2008)
9.	Mansfield, K G: 1 article (01/2008)
10.	Rajakumar, Premeela A: 1 article (04/2006)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Simian Acquired Immunodeficiency Syndrome:

1.	Interleukin-7 (Interleukin 7)IBA 02/01/2004 - "In 5 macaques that progressed to simian AIDS and death, elevated IL-7 levels were unable to restore T-cell homeostasis" 12/01/2005 - "These data contrast with our earlier studies in SIVmac-infected macaques, in which the IL-7 increase was delayed until 20 to 40 weeks after infection, just before the onset of simian AIDS" 02/01/2004 - "Further, studies in sooty mangabeys that do not progress to simian AIDS and that maintain stable T-cell numbers despite high levels of viral replication support the importance of IL-7 and T-cell homeostasis in disease progression" Get all the results and reference details, order at left...
2.	AntigensIBA 11/01/1989 - "A rapid, sensitive and specific antigen capture (AC) assay has been established for the detection of p27 core protein of SAIDS type-D retrovirus (SRV)" 11/01/1989 - "The relatedness of PMFV to further type D retroviruses (Mason-Pfizer monkey virus, MPMV; SAIDS retrovirus type 2, SRV-2) was also demonstrated by cross-hybridization of cloned DNAs under different stringencies (i) using full-length genomic probes of PMFV, MPMV, and SRV-2 and (ii) by DNA sequence analysis of regions of the group specific antigen (gag) protease (prt), polymerase (pol), and envelope (env) genes." 07/18/1986 - "The envelope antigen of the West African virus can be recognized by serum from a macaque with simian AIDS infected by the simian retrovirus termed STLV-IIImac, suggesting that the West African AIDS virus may be more closely related to this simian virus than to LAV" 07/01/1985 - "Although the antigens of the three prototype AIDS viruses were similar, no cross-reactivity with the SAIDS virus was detected" 08/01/2007 - "A subsequent study will evaluate the ability of rSVV vaccines expressing SIV antigens to protect nonhuman primates against simian AIDS." Get all the results and reference details, order at left...
3.	DNA (Deoxyribonucleic Acid)IBA 04/20/1984 - "Nucleic acid hybridization studies reveal that the origin of the SAIDS-D isolate may reside in Old World monkey (subfamily Colobinae) cellular DNA." 04/25/2006 - "DNA immunization in combination with effective antiretroviral drug therapy controls viral rebound and prevents simian AIDS after treatment is discontinued." 08/01/2002 - "In contrast, animals that were inoculated with SIV at 11 weeks after RhCMV infection rarely exhibited RhCMV DNA in plasma, had low copy numbers of RhCMV DNA in most tissues, and did not develop early onset of SAIDS or activated RhCMV" 07/01/1989 - "SRV-1 DNA and RNA have previously been detected in the brains of rhesus monkeys with SAIDS in the absence of viral antigen or neuropathological lesions" Get all the results and reference details, order at left...
4.	Interleukin-6 (Interleukin 6)IBA 01/01/2007 - "RESULTS: Results confirmed the sensitivity of LCL8664, an immunoblastic SAIDS-NHL cell line, to TGF-beta1-mediated growth inhibition, and further demonstrated the partial rescue by simultaneous treatment with IL-6" 01/01/2007 - "CONCLUSION: These studies indicate that the sensitivity of immunoblastic AIDS- or SAIDS-DLBCL to TGF-beta1-mediated growth inhibition may be overcome through the stimulation of proliferative and anti-apoptotic signals by IL-6, particularly through the rapid activation of STAT3." 06/01/1991 - "Interleukin-6 and retroperitoneal fibromatosis from SRV-2-infected macaques with simian AIDS." 01/01/2007 - "The present study was conducted to assess whether other SAIDS-NHL and AIDS-NHL cell lines are similarly sensitive to the growth inhibitory effects of TGF-beta, and to test the hypothesis that interleukin-6 (IL-6) may represent a counteracting positive influence in their growth regulation" 06/01/2001 - "Steroidal anti-inflammatory drugs (SAIDs) exhibited significant inhibitory effects at 100 microM on the IL-6 bioactivity, and their inhibitory potencies were in the order of budesonide (IC50=2.2 microM)>hydrocortisone 21-hemisuccinate (6.7 microM), prednisolone (7.5 microM), betamethasone (10.9 microM)>dexamethasone (18.9 microM) and triamcinolone acetonide (24.1 microM)" Get all the results and reference details, order at left...
5.	Non-Steroidal Anti-Inflammatory Agents (NSAIDs)IBA 07/01/2005 - "The influence of treatment with steroidal (SAIDs) and non-steroidal (NSAIDs) anti-inflammatory drugs on inflammatory markers in thirty, 6-8 week old calves with induced bronchopneumonia was investigated" 11/01/1994 - "Pharmacological control of inflammation by steroidal (SAIDs) and nonsteroidal (NSAIDs) antiinflammatory drugs is of substantial clinical importance" 07/01/1996 - "Our objective was to study the relationship between dispensed aspirin, nonaspirin nonsteroidal antiinflammatory drugs (NSAIDs), steroidal antiinflammatory drugs (SAIDs), acetaminophen, calcium, psyllium, and multivitamin preparations and the risk for subsequent colorectal adenoma and adenocarcinoma" Get all the results and reference details, order at left...
6.	Quinolinic AcidIBA 06/01/1990 - "In the present study, inoculation of macaques with D/1/California, an immunosuppressive serotype 1 type D retrovirus, was associated with acute and chronic increases in CSF and serum quinolinic acid concentrations in macaques that had developed SAIDS, a simian disease analogous to AIDS in humans--particularly macaques with demonstrable opportunistic infections" 06/01/1990 - "CSF quinolinic acid, but not kynurenic acid, was also increased in viremic macaques with SAIDS-related complex (2.4-fold) and asymptomatic virus positive carriers (3.4-fold)" 07/01/1997 - "Quinolinic acid and lymphocyte subsets in the intrathecal compartment as biomarkers of SIV infection and simian AIDS." 06/01/1990 - "Kynurenic acid, an antagonist of excitatory amino acid receptors as well as the excitotoxic effects of quinolinic acid, was also increased in the CSF of SAIDS macaques, but to a significantly lesser degree than was quinolinic acid (kynurenic acid, 1.8-fold; quinolinic acid, 15.6-fold)" Get all the results and reference details, order at left...
7.	KynurenineIBA 02/01/1991 - "In the present study, increased activity of indoleamine-2,3-dioxygenase (IDO), the first enzyme of the kynurenine pathway, occurred in cerebral cortex and lung of macaques with clinical SAIDS" 06/01/1990 - "Increased activity of indoleamine-2,3-dioxygenase, the first enzyme of the kynurenine pathway, was indicated in the macaques with SAIDS by reduced serum L-tryptophan and elevated serum L-kynurenine concentrations" Get all the results and reference details, order at left...
8.	NeopterinIBA 05/01/1991 - "Normal neopterin concentrations in the CSF were found in macaques with SAIDS-related complex as well as asymptomatic, viremic macaques" 05/01/1991 - "However, the absence of macrophage infiltrates in the brain of the infected macaques suggests a non-macrophage source of both increased CSF neopterin and tryptophan metabolites in the SAIDS macaques." 05/01/1991 - "In the present study, macaques with clinical simian AIDS (SAIDS) infected with the immunosuppressive type-D retrovirus D/1/California had increased concentrations of CSF neopterin but not of biopterin beginning soon after seroconversion" Get all the results and reference details, order at left...
9.	Transforming Growth Factor beta (TGF-beta)IBA 01/01/2007 - "A recent study of SAIDS-NHL demonstrated a lymphoma-derived cell line to be sensitive to the growth inhibitory effects of the ubiquitous cytokine, transforming growth factor-beta (TGF-beta)" 01/01/2007 - "The present study was conducted to assess whether other SAIDS-NHL and AIDS-NHL cell lines are similarly sensitive to the growth inhibitory effects of TGF-beta, and to test the hypothesis that interleukin-6 (IL-6) may represent a counteracting positive influence in their growth regulation" Get all the results and reference details, order at left...
10.	VaccinesIBA 08/01/2007 - "A subsequent study will evaluate the ability of rSVV vaccines expressing SIV antigens to protect nonhuman primates against simian AIDS." Get all the results and reference details, order at left...
81 Drugs and Important Bio-Agents and 75 more articles analyzed in the Research Interface, order at left...

Therapies and Procedures

1.	Drug Therapy (Chemotherapy) 04/25/2006 - "DNA immunization in combination with effective antiretroviral drug therapy controls viral rebound and prevents simian AIDS after treatment is discontinued." Get all the results and reference details, order at left...
2.	Aftercare (After-Treatment) 04/25/2006 - "DNA immunization in combination with effective antiretroviral drug therapy controls viral rebound and prevents simian AIDS after treatment is discontinued." Get all the results and reference details, order at left...
2 Therapies and Procedures and 1 more articles analyzed in the Research Interface, order at left...

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