Bronchoconstrictor Agents

Agents causing the narrowing of the lumen of a bronchus or bronchiole.

Also Known As:

Bronchoconstrictor Effect; Bronchoconstrictor Effects; Bronchoconstrictors; Agents, Bronchial-Constricting; Agents, Bronchoconstrictor; Bronchial Constricting Agents; Effect, Bronchoconstrictor; Effects, Bronchoconstrictor; Bronchial-Constricting Agents

Networked: 123 relevant articles (3 outcomes, 7 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Chemical Actions and Uses
- Pharmacologic Actions: 160
  - Therapeutic Uses: 47080
    - Respiratory System Agents: 148
      - Bronchoconstrictor Agents: 123
  - Physiological Effects of Drugs: 1
    - Peripheral Nervous System Agents: 5
      - Autonomic Agents: 186
        Bronchoconstrictor Agents: 123

Experts

1.	Bisgaard, H: 2 articles (02/2001 - 01/2001)
2.	Nazemiyeh, Masoud: 1 article (01/2019)
3.	Nouri-Vaskeh, Masoud: 1 article (01/2019)
4.	Saeedi, Ehsan: 1 article (01/2019)
5.	Sharifi, Akbar: 1 article (01/2019)
6.	Somi, Mohammad Hossein: 1 article (01/2019)
7.	Drvenica, Mirjana: 1 article (07/2018)
8.	Hromis, Sanja: 1 article (07/2018)
9.	Ilic, Aleksandra: 1 article (07/2018)
10.	Jankovic, Jelena: 1 article (07/2018)

Related Diseases

1.	Asthma (Bronchial Asthma) 02/01/2013 - "Asthma is characterized in part by variable airflow obstruction and non-specific hyperresponsiveness to a variety of bronchoconstrictors, both of which are mediated by the airway smooth muscle (ASM). " 09/01/2007 - "beta(2)-adrenoceptor agonists are the mainstay for the acute symptomatic treatment of asthma and provide effective bronchoprotection to a wide range of bronchoconstrictor agents. " 03/01/2006 - "CysLTs (LTC(4), LTD(4), and LTE(4)) are potent bronchoconstrictors that play an important role in asthma. " 08/01/2002 - "Bronchoconstrictor effect of deep inspiration in asthma." 07/15/2001 - "These findings support the evidence that CysLTs, in addition to being potent bronchoconstrictors, also provoke profound disturbances of pulmonary gas exchange in asthma."
2.	Bronchial Hyperreactivity 11/01/2007 - "There is no evidence that antenatal smoking exposure increases bronchial hyperreactivity, rather it may be associated with a diminished response to both bronchoconstrictors and bronchodilators in infants." 01/01/1992 - "Ozone induced marked (6-250-fold) bronchial hyperreactivity (BHR) to a range of inhaled, but not intravenous bronchoconstrictors. " 01/01/1991 - "During a remission, bronchial asthma children were examined for bronchial hyperreactivity and bronchial lability by means of graded physical exercise tests, and pharmacological tests with bronchoconstrictors and bronchodilators. " 04/17/1993 - "Sulphidopeptide leukotrienes are potent bronchoconstrictors and increase bronchial hyperreactivity, one of the hallmarks of asthma. " 01/01/1986 - "They: inhibit chemical mediators, whether these are performed, like histamine, or newly formed, like arachidonic acid metabolites (prostaglandins and leukotrienes) or the platelet-activating factor (PAF); restore the sensitivity of beta-adrenergic receptors to sympathomimetic drugs; exert a powerful anti-inflammatory effect, notably reducing bronchial mucus secretion; reduce bronchial hyperreactivity and modify the bronchial response to bronchoconstrictors; act on respiratory function and gas exchanges. "
3.	Airway Obstruction (Choking) 07/01/2003 - "In conclusion, this study suggests that thickening of the airway wall is a major mechanism for airway closure, whereas loss of airway-to-lung interdependence may contribute to the bronchoconstrictor effect of deep inhalation in the transition from normal lung function to airway obstruction in nonasthmatic smokers." 09/15/2000 - "These potent bronchoconstrictors inhibit mucociliary transport while stimulating mucus secretion, thereby contributing to airway obstruction. " 04/01/1987 - "In the present study, with a lower exposure level to SO2 (50 versus 200 ppm), we found similar histologic findings associated with airway obstruction, but in the absence of airway inflammation, responsiveness to inhaled bronchoconstrictors was unchanged. " 11/01/2010 - "Asthma comprises a triad of reversible airway obstruction, bronchial smooth muscle cell hyperreactivity to bronchoconstrictors, and chronic bronchial inflammation. " 08/01/2001 - "Asthma is a triad of intermittent airway obstruction, bronchial smooth muscle cell hyperreactivity to bronchoconstrictors, and chronic bronchial inflammation. "
4.	Inflammation (Inflammations) 12/01/2016 - "In addition to functioning as potent bronchoconstrictors, cysLTs contribute to airway inflammation through eosinophil and neutrophil chemotaxis, plasma exudation, and mucus secretion. " 08/01/2003 - "The cysteinyl LTs are potent bronchoconstrictors, which have additional effects on blood vessels, mucociliary clearance and eosinophilic inflammation. " 08/01/2002 - "This disease is characterized by airway hyperreactivity (AHR, defined by exaggerated airflow obstruction in response to bronchoconstrictors), mucus overproduction and chronic eosinophilic inflammation. " 02/01/2002 - "They are not only extremely potent bronchoconstrictors, but are also involved in the central mechanisms of the asthmatic inflammation and the subsequent remodelling of the airways. " 04/01/1987 - "This supports the theory that chronic airway inflammation may be associated with decreased responsiveness to inhaled bronchoconstrictors. "
5.	Bronchial Spasm 05/01/1986 - "At the 12.5 mg dose, however, we observed mild to moderate bronchospasm occurring within 5 min of administration, with a return toward baseline within 30 to 40 min. This bronchoconstrictor effect was unrelated to the low osmolarity of the drug solution (33 mosmol/L). " 08/01/1983 - "The results demonstrate that endogenously released leukotrienes can produce not only a direct bronchospasm but may enhance the effects of other bronchoconstrictor agents. " 01/01/1993 - "A rise in PGF2 alpha and TxB2 in manifest asthma points to their participation in bronchospasm formation suggesting an active role of these bronchoconstrictors in asthma pathogenesis. " 02/18/1992 - "Other bronchoconstrictor agents such as methacholine and serotonin did not potentiate the CNS-induced bronchospasm." 06/01/1990 - "The administration of NSAID inhibits the cyclo-oxygenase suppressing the enhanced basal production of these bronchoconstrictors and relieving the bronchospasm. "

Related Drugs and Biologics

1.	Leukotrienes
2.	Bronchodilator Agents (Bronchodilators)
3.	Platelet Activating Factor
4.	Thromboxanes
5.	Antigens
6.	Parasympatholytics (Antispasmodics)
7.	NZ 107
8.	Propranolol (Inderal)
9.	Bronchoconstrictor Agents
10.	Histamine (Histamine Dihydrochloride)

Related Therapies and Procedures

1.	Oral Administration