|1.||Lung Neoplasms (Lung Cancer)
|2.||Dyspnea (Shortness of Breath)
|3.||Pleural Effusion (Pleural Effusions)
|4.||Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
|1.||Lee, Y C Gary: 13 articles (09/2015 - 12/2003)|
|2.||Shi, Huan-Zhong: 10 articles (10/2015 - 12/2005)|
|3.||Rahman, Najib M: 10 articles (01/2015 - 04/2007)|
|4.||Tremblay, Alain: 8 articles (09/2015 - 02/2006)|
|5.||Kalomenidis, Ioannis: 8 articles (02/2014 - 10/2007)|
|6.||Davies, Robert J O: 8 articles (06/2012 - 12/2003)|
|7.||Terra, Ricardo Mingarini: 7 articles (11/2015 - 01/2009)|
|8.||Zhou, Qiong: 7 articles (10/2015 - 01/2011)|
|9.||Marchi, Evaldo: 7 articles (01/2015 - 01/2003)|
|10.||Light, Richard W: 7 articles (07/2012 - 12/2003)|
12/01/2006 - "Our study confirms that intrapleural talc carries good results in the treatment of malignant pleural effusion. "
01/01/2013 - "While talc is now accepted to be a worldwide gold-standard sclerosing agent for treating malignant pleural effusion, it is not yet approved in Japan. "
04/01/2007 - "The present study evaluated the angiogenic balance in the pleural space in patients with malignant pleural effusions (MPE) following talc insufflation. "
12/01/1996 - "We designed a prospective, randomized study to compare video-assisted thoracoscopic talc insufflation with bedside talc slurry in the treatment of malignant pleural effusion. "
12/01/2014 - "This case series summarizes the safety and efficacy data of all patients (24) with a symptomatic malignant pleural effusion who underwent talc pleurodeses via IPCs between December 2010 and July 2013. "
|2.||Bleomycin (Blenoxane)FDA LinkGeneric
01/01/2011 - "The purpose of this study was to assess the efficacy of bleomycin in the treatment of malignant pleural effusion. "
01/01/1989 - "Fifty-eight patients with malignant pleural effusions were entered into a prospectively randomized clinical trial comparing the efficacy of a local instillation of bleomycin or corynebacterium parvum (C. "
01/01/1989 - "A randomized trial of intracavitary bleomycin and Corynebacterium parvum in the control of malignant pleural effusions."
12/01/2011 - "Bleomycin in malignant pleural effusion. "
01/01/2011 - "Bleomycin in the treatment of 50 cases with malignant pleural effusion."
|3.||Tetracycline (Achromycin)FDA LinkGeneric
07/01/1993 - "These results suggest pleural drainage is the best treatment in patients with malignant pleural effusion, however, the association of Tetracycline instillation allows better results."
02/15/1983 - "Intrapleural instillation of tetracycline (TCN) has been shown to be effective in preventing the recurrence of malignant pleural effusions. "
02/15/1983 - "Thirty patients with malignant pleural effusions were randomized in a double-blind trial to receive intrapleural administration of either 500 mg of tetracycline in solution (pH = 2.8) or a solution of similar pH and appearance. "
07/01/1994 - "Alternatives to intravenous tetracycline hydrochloride for malignant pleural effusions."
07/01/1988 - "Forty-three patients with recurrent malignant pleural effusions were included in a prospective protocol of treatment with two different types of tetracycline. "
|4.||Cisplatin (Platino)FDA LinkGeneric
12/01/2008 - "To observe the clinical efficacy of Xiaoshui decoction (XSD) combined with intrapleural perfusion of cisplatin in the treatment of malignant pleural effusion. "
12/01/2008 - "Clinical observation on the efficacy of Xiaoshui decoction combined with intrapleural perfusion of cisplatin in treating malignant pleural effusion."
01/01/2015 - "Intrapleural cisplatin for management of malignant pleural effusion in a patient with plasma cell leucaemia."
09/18/2006 - "Hypotonic cisplatin treatment for malignant pleural effusion of NSCLC is therefore considered to be feasible and effective. "
01/01/2000 - "We determined the toxicity and pharmacokinetics of high-dose intrapleural cisplatin (CDDP) as a treatment of malignant pleural effusions (MPE). "
|5.||Doxycycline (Vibramycin)FDA LinkGeneric
03/01/1998 - "We used intrapleural doxycycline at doses greater than 2000 mg in 16 malignant pleural effusion (14 patients). "
03/01/1998 - "Malignant pleural effusions treated with high dose intrapleural doxycycline: clinical efficacy and tolerance."
05/01/1993 - "Intrapleural doxycycline control of malignant pleural effusions."
01/01/1988 - "In 18 patients with histologically or cytologically proven malignant pleural effusion, 500 mg doxycycline hydrochloride diluted in 30 ml of saline was instilled into the emptied pleural space. "
01/01/1988 - "Treatment of malignant pleural effusion with doxycycline."
01/01/2006 - "The purpose of this study was to determine, in a case-control study, whether or not the rate of lymphocytes in malignant pleural effusion (lymphocyte rate) influences the therapeutic efficacy of intrapleural OK-432. "
03/01/2006 - "Intrathoracic injection of OK-432 is a feasible treatment for malignant pleural effusion. "
01/01/2006 - "We conclude that intrapleural OK-432 is useful for malignant pleural effusion patients with a high lymphocyte rate before treatment."
01/01/2006 - "In the High lymphocyte rate group, intrapleural OK-432 for malignant pleural effusion was effective. "
01/01/2006 - "The lymphocyte rate in malignant pleural effusion influences the response rate to treatment by intrapleural OK-432. "
|7.||Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
10/01/2002 - "We also propose that measurement of pleural VEGF is helpful for the diagnosis of malignant pleural effusion."
07/01/2005 - "This study was conducted to assess the usefulness of VEGF for diagnosing malignant and non-malignant pleural effusions of various causes. "
02/05/2015 - "VEGF differed significantly in benign and malignant pleural effusions, which contributed to differential diagnosis results of benign and malignant pleural effusions. "
10/01/2014 - "Inflammatory and malignant pleural effusions are rich in VEGF content while mesothelial cells produce and excrete VEGF. "
06/01/2013 - "Vascular endothelial growth factor-A (VEGF-A) has been implicated as a critical cytokine in the formation of malignant pleural effusions. "
11/01/2013 - "One thousand one hundred forty-five patients with histologically or cytologically confirmed NSCLC (stage IIIB with malignant pleural effusion, stage IV, or recurrent) received four cycles of chemotherapy plus bevacizumab. "
02/01/2013 - "Bevacizumab plus chemotherapy for advanced non-squamous non-small-cell lung cancer with malignant pleural effusion."
06/01/2013 - "Therefore antiangiogenic therapies such as Bevacizumab, a monoclonal antibody targeting VEGF-A, may have a potential role in the management of malignant pleural effusions. "
06/01/2013 - "Intrapleural combination therapy with bevacizumab and cisplatin for non-small cell lung cancer‑mediated malignant pleural effusion."
03/01/2014 - "The expression of VEGF in the pleural effusion and serum plays a guiding role in monitoring the efficacy of bevacizumab in the treatment of malignant pleural effusion."
|9.||Mitoxantrone (Novantrone)FDA LinkGeneric
03/01/1991 - "From 11/87 until 7/90 103 patients entered a prospective randomized trial on the treatment of malignant pleural effusions (MPE) with intrapleural mitoxantrone versus placebo (pleural tube alone with instillation of isotonic NaCl). "
10/01/1998 - "Mitoxantrone is reported as having potential in malignant pleural effusion. "
03/01/1995 - "A group of 21 patients with malignant pleural effusions were treated with the instillation of 40 mg mitoxantrone intrapleurally, after complete fluid drainage. "
02/01/1992 - "Local therapy of malignant pleural effusion with mitoxantrone."
03/01/1995 - "Intrapleural mitoxantrone for the palliative treatment of malignant pleural effusions."
|10.||Carboplatin (JM8)FDA LinkGeneric
04/01/1997 - "The pharmacokinetics of DDP and CBDCA were studied in 10 patients with malignant pleural effusion treated intrapleurally with a combination of DDP (60 mg/m2) and CBDCA (270 mg/m2) and in additional patients who received the same doses of drugs administered intravenously as single agents or in combination. "
03/01/2012 - "This was a rare case of adenocarcinoma of the lung with malignant pleural effusion treated effectively by PEM/CBDCA chemotherapy, a safe treatment for an elderly patient."
04/01/1997 - "Carboplatin and cisplatin pharmacokinetics after intrapleural combination treatment in patients with malignant pleural effusion."
10/01/2007 - "Eligibility required measurable disease; stage III B with malignant pleural effusion or stage IV disease, with a performance status (PS) of ECOG 0-2. Chemotherapy consisted of 24 hours continuous infusion of paclitaxel at 135 mg/m(2) on day 1, followed by carboplatin (AUC=6) on day 2. Treatment was repeated at 3-week intervals for a total of 6 cycles. "
04/01/2006 - "Pleurodesis with carboplatin in elderly patients with malignant pleural effusion and lung adenocarcinoma."
06/01/2003 - "Chemical pleurodesis can be accomplished with good results in < 24 h in the majority of patients with malignant pleural effusions."
11/01/1997 - "In conclusion, VATS has provided a high positive diagnosis of patients with malignant pleural effusions not diagnosed by conventional methods and good results in pleurodesis, but some operating skills must be emphasized."
10/01/2011 - "Although pleurodesis is an effective treatment for malignant pleural effusion, we hesitate to use in patients with poor performance status (PS) because of its side effects. "
03/26/1999 - "[Effective treatment of malignant pleural effusion: Thoracoscopic talcum pleurodesis and pleuro-peritoneal shunt]."
01/01/1998 - "Chemical pleurodesis is an effective treatment of malignant pleural effusions, but indications must be individualised to optimise its results. "
07/01/2007 - "Pleural catheter may prove to be an important palliative modality in treating debilitated patients or patients with trapped lung who show symptomatic improvement with drainage; however, at the present time, these catheters cannot be considered a first line treatment option for patients with malignant pleural effusion. "
07/01/2007 - "The high success rates, low complication rates and efficacy in patients with a wide range of performance status support the use of tunneled pleural catheters as a first-line treatment for symptomatic malignant pleural effusion."
07/01/2001 - "Our study suggests that small-bore catheters may be effective in the treatment of malignant pleural effusions and deserve further evaluation in prospectively designed trials."
11/15/1999 - "A chronic indwelling pleural catheter is an effective treatment for the management of patients with symptomatic, recurrent, malignant pleural effusions. "
12/01/2009 - "The use of ambulatory pleural catheters for managing malignant pleural effusion is a safe and effective strategy. "
|3.||Chest Tubes (Chest Tube)
02/01/1993 - "Twenty-three patients with cytologically proven malignant pleural effusions were given IFN-alpha 2b 50 x 10(6) units in 50 ml normal saline (NS) by intrapleural instillation after partial or complete clearance of effusions by percutaneous aspiration or chest tube drainage. "
07/01/2001 - "Use of small-bore vs large-bore chest tubes for treatment of malignant pleural effusions."
04/01/1998 - "Curved chest tube for drainage of malignant pleural effusion."
09/01/1980 - "Small chest tube for malignant pleural effusions."
07/01/2001 - "All patients included in the study underwent drainage of malignant pleural effusions either by large-bore chest tube or by ultrasound-guided small-bore catheter. "
|4.||Drug Therapy (Chemotherapy)
01/01/2010 - "Current chemotherapy combinations for the first-line treatment of advanced disease (stage IIIB with malignant pleural effusion/stage IV) and chemoradiotherapy regimens for the treatment of unresectable locally advanced disease (stage IIIA and IIIB without malignant pleural effusion) appear to have reached an efficacy plateau. "
12/20/2007 - "In this noncomparative, randomized trial, chemotherapy-naïve patients with recurrent/metastatic NSCLC (stage IV or stage IIIB with malignant pleural effusion) were eligible. "
01/01/2006 - "Eligible patients in this trial had stage IIIB (with malignant pleural effusion) or stage IV NSCLC with no prior chemotherapy. "
03/01/2002 - "Phase II study of repeated intrapleural chemotherapy using implantable access system for management of malignant pleural effusion."
10/15/1997 - "For stage IIIB (excluding patients with malignant pleural effusion or supraclavicular nodes) a further prospective randomized trial is on its way testing chemotherapy followed by a definitive concurrent chemoradiation approach up to 65 Gy radiation dose versus a multimodality program similar to our phase-II protocol with the inclusion of definitive surgery. "
11/01/2002 - "Primary treatment of malignant pleural effusions: video-assisted thoracoscopic surgery poudrage versus tube thoracostomy."
05/15/1997 - "In patients who have malignant pleural effusion, it is difficult to diagnose trapped lung before thoracoscopy, thoracostomy, and drainage of the effusion. "
10/20/2005 - "[A randomized study of small bore catheter thoracostomy closed drainage versus conventional pleural aspiration in the treatment of malignant pleural effusions]."
08/01/2006 - "The objective of this retrospective study was to compare the effectiveness of patients undergoing pleurodesis through VATS versus tube thoracostomy for malignant pleural effusion (MPE). "
08/01/2006 - "Malignant pleural effusion treatment outcomes: pleurodesis via video-assisted thoracic surgery (VATS) versus tube thoracostomy."