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Didanosine (Videx)

A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. Didanosine is a potent inhibitor of HIV replication, acting as a chain-terminator of viral DNA by binding to reverse transcriptase; ddI is then metabolized to dideoxyadenosine triphosphate, its putative active metabolite.
Also Known As:
Videx; 2',3' Dideoxyinosine; Bristol-Myers Brand of Didanosine; Bristol-Myers Squibb Brand of Didanosine; NSC-612049; Bristol Myers Brand of Didanosine; Bristol Myers Squibb Brand of Didanosine; NSC 612049; NSC612049; 2',3'-Dideoxyinosine; Dideoxyinosine; ddI (Antiviral); Inosine, 2',3'-dideoxy-
Networked: 549 relevant articles (24 outcomes, 111 trials/studies)

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Drug Context: Research Results

Experts

1. Soriano, Vincent: 7 articles (05/2010 - 05/2003)
2. Barreiro, Pablo: 6 articles (05/2010 - 05/2003)
3. Ribera, Esteban: 5 articles (01/2009 - 01/2005)
4. Lori, Franco: 5 articles (07/2005 - 01/2003)
5. Maida, Ivana: 4 articles (05/2010 - 04/2006)
6. Perronne, Christian: 4 articles (03/2008 - 12/2004)
7. Lisziewicz, Julianna: 4 articles (07/2005 - 01/2003)
8. Haas, David W: 3 articles (06/2014 - 08/2006)
9. Robbins, Gregory K: 3 articles (06/2014 - 08/2006)
10. Ledergerber, Bruno: 3 articles (01/2011 - 09/2005)

Related Diseases

1. HIV Infections (HIV Infection)
2. Acquired Immunodeficiency Syndrome (AIDS)
3. Infection
4. Pancreatitis
5. AIDS-Related Complex (ARC)

Related Drugs and Biologics

1. Zidovudine (Retrovir)
2. Nevirapine (Viramune)
3. Stavudine (Zerit)
4. Zalcitabine (Hivid)
5. Hydroxyurea (Hydrea)
6. Immunoglobulins (Immunoglobulin)
7. Lamivudine (3TC)
8. efavirenz (Sustiva)
9. emtricitabine (Emtriva)
10. Biological Markers (Surrogate Marker)

Related Therapies and Procedures

1. Art Therapy
2. Aftercare (After-Treatment)
3. Oral Administration
4. Highly Active Antiretroviral Therapy (HAART)
5. Drug Therapy (Chemotherapy)