Dideoxyadenosine
15
relevant articles (2 outcomes,
1 trials/studies)
found for this Bio-Agent
Description:
A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is an inhibitor of HIV replication, acting as a chain-terminator of viral DNA by binding to reverse transcriptase. Its principal side effect is nephrotoxicity. In vivo, dideoxyadenosine is rapidly metabolized to DIDANOSINE (ddI) by enzymatic deamination; ddI is then converted to dideoxyinosine monophosphate and ultimately to dideoxyadenosine triphosphate, the putative active metabolite.
Also Known As:
2',3' Dideoxyadenosine; 2',3'-Dideoxyadenosine; ddA (Antiviral); Adenosine, 2',3'-dideoxy-
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Bio-Agent Context: Research Results