HOMEPRODUCTSSERVICESCOMPANYCONTACTFAQResearchDictionaryPharmaMobileSign Up FREE or Login

Zalcitabine (Hivid)

A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is a potent inhibitor of HIV replication at low concentrations, acting as a chain-terminator of viral DNA by binding to reverse transcriptase. Its principal toxic side effect is axonal degeneration resulting in peripheral neuropathy.
Also Known As:
Hivid; 2',3' Dideoxycytidine; HIVID Roche; Hoffman-La Roche Brand of Zalcitabine; NSC-606170; Roche Brand of Zalcitabine; NSC 606170; NSC606170; 2',3'-Dideoxycytidine; Dideoxycytidine; ddC (Antiviral); Cytidine, 2',3'-dideoxy-
Networked: 236 relevant articles (12 outcomes, 36 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1. Levine, Jon D: 5 articles (08/2011 - 01/2004)
2. Walker, Ulrich A: 5 articles (12/2010 - 11/2002)
3. Kirschner, Janbernd: 4 articles (12/2010 - 01/2007)
4. Lebrecht, Dirk: 4 articles (12/2010 - 01/2007)
5. Liu, Shue: 3 articles (03/2014 - 11/2011)
6. Hao, Shuanglin: 3 articles (03/2014 - 11/2011)
7. White, Fletcher A: 3 articles (03/2013 - 07/2007)
8. Ripsch, Matthew S: 3 articles (03/2013 - 07/2007)
9. Deveaud, Catherine: 3 articles (12/2010 - 01/2008)
10. Bonnet, Jacques: 3 articles (12/2010 - 01/2008)

Related Diseases

1. Acquired Immunodeficiency Syndrome (AIDS)
2. HIV Infections (HIV Infection)
3. AIDS-Related Complex (ARC)
4. Disease Progression
5. Peripheral Nervous System Diseases (PNS Diseases)

Related Drugs and Biologics

1. Zidovudine (Retrovir)
2. Didanosine (Videx)
3. Zalcitabine (Hivid)
4. Ritonavir (Norvir)
5. Saquinavir (Invirase)
6. Antigens
7. Biological Markers (Surrogate Marker)
8. Antiviral Agents (Antivirals)
9. 2',3'-dideoxycytidine 5'-triphosphate
10. Lamivudine (3TC)

Related Therapies and Procedures

1. Oral Administration
2. First Aid (Aids, First)
3. Aftercare (After-Treatment)
4. Highly Active Antiretroviral Therapy (HAART)
5. Drug Therapy (Chemotherapy)