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bcr-abl Fusion Proteins

Translation products of a fusion gene derived from CHROMOSOMAL TRANSLOCATION of C-ABL GENES to the genetic locus of the breakpoint cluster region gene on chromosome 22. Several different variants of the bcr-abl fusion proteins occur depending upon the precise location of the chromosomal breakpoint. These variants can be associated with distinct subtypes of leukemias such as PRECURSOR CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; LEUKEMIA, MYELOGENOUS, CHRONIC, BCR-ABL POSITIVE; and NEUTROPHILIC LEUKEMIA, CHRONIC.
Also Known As:
Fusion Proteins, bcr-abl; Bcr-Abl Tyrosine Kinase; Oncogene Protein p185(bcr-abl); Oncogene Protein p230(bcr-abl); p185(bcr-abl) Fusion Proteins; p190(bcr-abl) Fusion Proteins; p210(bcr-abl) Fusion Proteins; p230(bcr-abl) Fusion Proteins; Bcr Abl Tyrosine Kinase; Fusion Protein, bcr-abl; Fusion Proteins, bcr abl; Kinase, Bcr-Abl Tyrosine; Protein, bcr-abl Fusion; Tyrosine Kinase, Bcr-Abl; bcr abl Fusion Protein; bcr abl Fusion Proteins; Oncogene Protein p190(bcr-abl); Oncogene Protein p210(bcr-abl); bcr-abl Fusion Protein
Networked: 781 relevant articles (69 outcomes, 30 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Kantarjian, Hagop: 22 articles (01/2022 - 01/2000)
2. Cortes, Jorge: 16 articles (01/2020 - 06/2004)
3. Hochhaus, Andreas: 15 articles (01/2018 - 02/2002)
4. Jabbour, Elias: 13 articles (01/2022 - 07/2007)
5. Kantarjian, Hagop M: 13 articles (01/2020 - 03/2002)
6. Druker, Brian J: 13 articles (01/2015 - 01/2002)
7. Bhatia, Ravi: 11 articles (01/2020 - 06/2003)
8. Saglio, Giuseppe: 11 articles (08/2017 - 02/2002)
9. Baccarani, Michele: 11 articles (01/2011 - 02/2002)
10. Cortes, Jorge E: 10 articles (01/2020 - 07/2002)

Related Diseases

1. BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia)
2. Philadelphia Chromosome
3. Leukemia
4. Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia)
5. Blast Crisis (Blast Phase)

Related Drugs and Biologics

1. Imatinib Mesylate (Gleevec)
2. Tyrosine Kinase Inhibitors
3. Phosphotransferases (Kinase)
4. Dasatinib (BMS 354825)
5. nilotinib
6. Protein-Tyrosine Kinases (Tyrosine Kinase)
7. Protein Kinase Inhibitors
8. Ropivacaine (Naropin)
9. Proteins (Proteins, Gene)
10. Peptides (Polypeptides)

Related Therapies and Procedures

1. Therapeutics
2. Stem Cell Transplantation
3. Immunotherapy
4. Molecular Targeted Therapy
5. Hematopoietic Stem Cell Transplantation