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bcr-abl Fusion Proteins

Translation products of a fusion gene derived from CHROMOSOMAL TRANSLOCATION of C-ABL GENES to the genetic locus of the breakpoint cluster region gene on chromosome 22. Several different variants of the bcr-abl fusion proteins occur depending upon the precise location of the chromosomal breakpoint. These variants can be associated with distinct subtypes of leukemias such as PRECURSOR CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; LEUKEMIA, MYELOGENOUS, CHRONIC, BCR-ABL POSITIVE; and NEUTROPHILIC LEUKEMIA, CHRONIC.
Also Known As:
Fusion Proteins, bcr-abl; Oncogene Protein p185(bcr-abl); Oncogene Protein p230(bcr-abl); p185(bcr-abl) Fusion Proteins; p190(bcr-abl) Fusion Proteins; p210(bcr-abl) Fusion Proteins; p230(bcr-abl) Fusion Proteins; Fusion Proteins, bcr abl; bcr abl Fusion Proteins; Oncogene Protein p190(bcr-abl); Oncogene Protein p210(bcr-abl)
Networked: 18 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1. Döring, Claudia: 1 article (04/2015)
2. Thalheimer, Frederic B: 1 article (04/2015)
3. Ottmann, Oliver Gerhard: 1 article (04/2015)
4. Mian, Afsar Ali: 1 article (04/2015)
5. Oancea, Claudia: 1 article (04/2015)
6. Metodieva, Anna: 1 article (04/2015)
7. Ruthardt, Martin: 1 article (04/2015)
8. Rafiei, Anahita: 1 article (04/2015)
9. Hansmann, Martin Leo: 1 article (04/2015)
10. Ruhrberg, Christiana: 1 article (06/2014)

Related Diseases

1. Leukemia
2. BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia)
3. Philadelphia Chromosome
4. Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia)
5. Pathologic Neovascularization

Related Drugs and Biologics

1. Protein-Tyrosine Kinases (Tyrosine Kinase)
2. Oncogene Proteins (Oncogene Protein)
3. imatinib (Gleevec)

Related Therapies and Procedures

1. Stem Cell Transplantation
2. Transplants (Transplant)