Translation products of a fusion gene derived from CHROMOSOMAL TRANSLOCATION of C-ABL GENES to the genetic locus of the breakpoint cluster region gene on chromosome 22. Several different variants of the bcr-abl fusion proteins occur depending upon the precise location of the chromosomal breakpoint. These variants can be associated with distinct subtypes of leukemias such as PRECURSOR CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; LEUKEMIA, MYELOGENOUS, CHRONIC, BCR-ABL POSITIVE; and NEUTROPHILIC LEUKEMIA, CHRONIC.
Also Known As:
Fusion Proteins, bcr-abl; Bcr-Abl Tyrosine Kinase; Oncogene Protein p185(bcr-abl); Oncogene Protein p230(bcr-abl); p185(bcr-abl) Fusion Proteins; p190(bcr-abl) Fusion Proteins; p210(bcr-abl) Fusion Proteins; p230(bcr-abl) Fusion Proteins; Bcr Abl Tyrosine Kinase; Fusion Protein, bcr-abl; Fusion Proteins, bcr abl; Kinase, Bcr-Abl Tyrosine; Protein, bcr-abl Fusion; Tyrosine Kinase, Bcr-Abl; bcr abl Fusion Protein; bcr abl Fusion Proteins; Oncogene Protein p190(bcr-abl); Oncogene Protein p210(bcr-abl); bcr-abl Fusion Protein