Leukocyte-Adhesion Receptors

Family of proteins associated with the capacity of LEUKOCYTES to adhere to each other and to certain substrata, e.g., the C3bi component of complement. Members of this family are the LYMPHOCYTE FUNCTION-ASSOCIATED ANTIGEN-1; (LFA-1), the MACROPHAGE-1 ANTIGEN; (Mac-1), and the INTEGRIN ALPHAXBETA2 or p150,95 leukocyte adhesion protein. They all share a common beta-subunit which is the CD18 antigen. All three of the above antigens are absent in inherited LEUKOCYTE-ADHESION DEFICIENCY SYNDROME, which is characterized by recurrent bacterial infections, impaired pus formation, and wound healing as well as abnormalities in a wide spectrum of adherence-dependent functions of granulocytes, monocytes, and lymphoid cells.

Also Known As:

Networked: 19 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Castañeda, S: 1 article (11/2014)
2.	Cubero-Rueda, L: 1 article (11/2014)
3.	Esteban-Villafruela, A: 1 article (11/2014)
4.	Gamallo, C: 1 article (11/2014)
5.	García-Blanco, M J: 1 article (11/2014)
6.	García-Diez, A: 1 article (11/2014)
7.	García-García, C: 1 article (11/2014)
8.	González-Tajuelo, R: 1 article (11/2014)
9.	Muñoz-Calleja, C: 1 article (11/2014)
10.	Núñez-Andrade, N: 1 article (11/2014)

Related Diseases

1.	Glomerulonephritis 03/01/1999 - "Second, we discuss models of experimental glomerulonephritis and what we have learned about leukocyte adhesion receptors in the pathogenesis of glomerulonephritis through studies in knockout mice." 01/01/2000 - "Carl Ludwig Award 2000: experimental glomerulonephritis: the use of genetically deficient mice to elucidate the role of leukocytes and leukocyte adhesion receptors." 05/01/1999 - "Single gene knock-outs in mice have been used to define the biological role of leukocyte adhesion receptors, Fc-gamma receptors and complement in animal models of immune complex glomerulonephritis. "
2.	Ischemia 01/01/2000 - "The aim of this study was to test the hypothesis that agents which stabilize the mast cell membrane may modulate the phenotype of the vascular wall in a lung ischemia-reperfusion model, including altering expression of endothelial and leukocyte adhesion receptors and the inducible nitric oxide synthase (NOS-2). " 05/01/2000 - "Ischemia initiates leukocyte adhesion receptor expression, which is promoted by cytokine generation from the neuropil and activated monocytes. "
3.	Obesity 07/08/1997 - "Our results indicate that (i) leukocytes play a role in preventing excess body fat deposition and (ii) defects in leukocyte adhesion receptors can result in obesity." 07/08/1997 - "A new class of obesity genes encodes leukocyte adhesion receptors." 03/01/1999 - "These strains of mice have been very informative about the roles of cell adhesion molecules in leukocyte-endothelium interaction and have produced some surprises: roles for leukocyte adhesion receptors have been demonstrated in development as well as pathologies like obesity, and evidence for functional synergies between adhesion receptors have been provided. "
4.	Inflammation (Inflammations) 05/01/2011 - "Inhibiting the mitochondrial Ca2+ increase blocked the shedding and augmented inflammation, as denoted by increases in endothelial expression of the leukocyte adhesion receptor E-selectin and in microvascular leukocyte recruitment. " 09/01/2000 - "Leukocyte adhesion receptors, including the beta-integrin (CD11/CD18) family, play an important role in inflammation via their regulatory effects on leukocyte adhesion, transmigration, and function. "
5.	Abdominal Aortic Aneurysm 10/01/1994 - "To investigate whether activated leukocytes are present in salvaged blood, we measured complete blood counts and quantified the surface expression of the leukocyte adhesion receptors CD11b and CD18 in salvaged blood and arterial blood from six male patients undergoing elective abdominal aortic aneurysm repair. "

Related Drugs and Biologics

1.	Nitric Oxide Synthase Type II (Inducible Nitric Oxide Synthase)
2.	E-Selectin
3.	Intercellular Adhesion Molecule-1 (Intercellular Adhesion Molecule 1)
4.	Cytokines
5.	Ligands
6.	adhesion receptor
7.	Neutralizing Antibodies
8.	P-Selectin
9.	IgG Receptors (Fc gamma RI)
10.	Lymphocyte Function-Associated Antigen-1 (LFA-1)