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Factor XIIa (Coagulation Factor XIIa)

Activated form of factor XII. In the initial event in the intrinsic pathway of blood coagulation, kallikrein (with cofactor HIGH MOLECULAR WEIGHT KININOGEN) cleaves factor XII to XIIa. Factor XIIa is then further cleaved by kallikrein, plasmin, and trypsin to yield smaller factor XII fragments (Hageman-Factor fragments). These fragments increase the activity of prekallikrein to kallikrein but decrease the procoagulant activity of factor XII.
Also Known As:
Coagulation Factor XIIa; Activated Factor XII; Blood Coagulation Factor XII, Activated; Hageman-Factor Fragments; Prekallikrein Activator; Activator, Prekallikrein; Factor XIIa, Coagulation; Fragments, Hageman-Factor; Hageman Factor Fragments; XIIa, Coagulation Factor; Factor XII, Activated
Networked: 65 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Experts

1. Grundt, Heidi: 4 articles (12/2009 - 04/2003)
2. Morrissey, James H: 2 articles (09/2015 - 12/2011)
3. Smith, Stephanie A: 2 articles (12/2011 - 11/2010)
4. Nilsen, Dennis W T: 2 articles (12/2009 - 04/2003)
5. Pritchard, David: 2 articles (12/2009 - 12/2006)
6. Pönitz, Volker: 2 articles (12/2009 - 12/2006)
7. Nilsen, Dennis Winston T: 2 articles (12/2006 - 02/2004)
8. Cugno, Massimo: 2 articles (07/2005 - 04/2004)
9. Praus, Michael: 2 articles (02/2004 - 10/2002)
10. Kuebler, Wolfgang M: 2 articles (02/2004 - 10/2002)

Related Diseases

1. Inflammation
2. Coronary Disease (Coronary Heart Disease)
3. Brain Ischemia (Cerebral Ischemia)
4. Thrombosis (Thrombus)
5. Hemorrhage

Related Drugs and Biologics

1. Factor XII (Hageman Factor)
2. Kallikreins (Kallikrein)
3. Prothrombin (Factor II)
4. Bradykinin
5. Thrombin
6. Factor XI (Plasma Thromboplastin Antecedent)
7. Plasma Kallikrein
8. High-Molecular-Weight Kininogen (Kininogen, High Molecular Weight)
9. Factor XIa (Coagulation Factor XIa)
10. Fibrinogen (Factor I)

Related Therapies and Procedures

1. Transplants (Transplant)
2. Thrombolytic Therapy
3. Membrane Oxygenators (Membrane Oxygenator)