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Factor VIIIa

Activated form of factor VIII. The B-domain of factor VIII is proteolytically cleaved by thrombin to form factor VIIIa. Factor VIIIa exists as a non-covalent dimer in a metal-linked (probably calcium) complex and functions as a cofactor in the enzymatic activation of factor X by factor IXa. Factor VIIIa is similar in structure and generation to factor Va.
Also Known As:
Blood Coagulation Factor VIII, Activated; Factor VIIIa Heavy Chain, 200 kDa Isoform; Factor VIIIa Heavy Chain, 92 kDa Isoform; Factor VIIIa Light Chain; Activated Factor VIII; Factor VIII, Thrombin Activated; Factor VIIIa, Coagulation; Thrombin-Activated Factor VIII; VIIIa, Coagulation Factor; Coagulation Factor VIIIa; Factor VIII, Activated; Factor VIII, Thrombin-Activated; Blood-coagulation factor VIIIa, procoagulant
Networked: 24 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Experts

1. Cramer, Thomas J: 1 article (06/2011)
2. Gale, Andrew J: 1 article (06/2011)
3. Whincup, Peter H: 1 article (04/2008)
4. Rumley, Ann: 1 article (04/2008)
5. Ramsay, Sheena: 1 article (04/2008)
6. Lowe, Gordon D O: 1 article (04/2008)
7. Wannamethee, S Goya: 1 article (04/2008)
8. Morris, Richard W: 1 article (04/2008)
9. Thoumsin, Henri: 1 article (01/2008)
10. Seidel, Laurence: 1 article (01/2008)

Related Diseases

1. Autolysis
2. Acute-Phase Reaction
3. Hemophilia A (Haemophilia)
4. Activated Protein C Resistance (APC Resistance)
08/01/1995 - "To overcome the limitations of aPTT-based assays in the diagnosis of APC resistance, we have developed a chromogenic assay which is based on the capacity of APC to limit the generation of factor Xa by inactivating factor VIIIa in plasma. "
08/15/1994 - "We developed an amidolytic assay for the determination of APC-resistance by inhibition of factor Xa (F Xa) generation, expecting it to be a result of factor VIIIa (F VIIIa) inactivation. "
01/01/2001 - "Serum levels of modified activated protein C resistance, antithrombin III, fibrinogen, factor VIIIa, factor VIII, factor IX, activated partial thromboplastin time, prothrombin time, thrombin time, and lipoprotein (a) were measured before and 6 months after the treatment and analyzed for changes in extrinsic and intrinsic coagulation parameters. "
01/01/2006 - "The coagulations tests were performed including: prothrombin time, activated partial thromboplastic time (aPTT), fibrinogen, anticardiolipin antibodies, lupus anticoagulant, antithrombin, protein C and protein S activities, factor VIII, activated protein C (APC) resistance, factor V Leiden, and quantitative D-dimers. "
04/01/2008 - "Men in lower social classes had higher mean levels of C-reactive protein, fibrinogen, interleukin-6, white blood cell count, von Willebrand factor (vWF), factor VIII, activated protein C (APC) resistance, plasma viscosity, fibrin D-dimer and platelet count, compared to higher social class groups; but not of tissue plasminogen activator antigen, haematocrit or activated partial prothrombin time. "
5. Hemorrhage

Related Drugs and Biologics

1. Factor IXa (Coagulation Factor IXa)
2. Factor VIII (Coagulation Factor VIII)
3. Protein S
4. Protein C
5. Fibrinogen (Factor I)
6. Factor Xa (Coagulation Factor Xa)
7. Factor VIIIa
8. von Willebrand Factor
9. Fibrin
10. Factor X (Stuart Factor)

Related Therapies and Procedures

1. Salvage Therapy