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Complement C5a (Complement 5a)

The minor fragment formed when C5 convertase cleaves C5 into C5a and COMPLEMENT C5B. C5a is a 74-amino-acid glycopeptide with a carboxy-terminal ARGININE that is crucial for its spasmogenic activity. Of all the complement-derived anaphylatoxins, C5a is the most potent in mediating immediate hypersensitivity (HYPERSENSITIVITY, IMMEDIATE), smooth MUSCLE CONTRACTION; HISTAMINE RELEASE; and migration of LEUKOCYTES to site of INFLAMMATION.
Also Known As:
Complement 5a; C5a Complement; Complement Component 5a; 5a, Complement Component; C5a, Complement; Complement, C5a; Component 5a, Complement
Networked: 78 relevant articles (0 outcomes, 8 trials/studies)

Bio-Agent Context: Research Results

Experts

1. Li, Yan: 4 articles (03/2015 - 04/2010)
2. Woodruff, Trent M: 3 articles (09/2014 - 07/2011)
3. Okada, Noriko: 3 articles (11/2013 - 06/2003)
4. Okada, Hidechika: 3 articles (11/2013 - 06/2003)
5. Xu, Ruonan: 3 articles (03/2013 - 04/2010)
6. Lambris, John D: 3 articles (12/2012 - 12/2003)
7. Taylor, Stephen M: 3 articles (11/2011 - 01/2004)
8. Han, Gencheng: 3 articles (07/2011 - 04/2010)
9. Wang, Renxi: 3 articles (07/2011 - 04/2010)
10. Shen, Beifen: 3 articles (07/2011 - 04/2010)

Related Diseases

1. Sepsis (Septicemia)
2. Inflammation
3. Pain (Aches)
4. Meningitis
5. Hyperalgesia

Related Drugs and Biologics

1. Complement System Proteins (Complement)
2. Hydrogen Peroxide (Hydroperoxide)
3. Messenger RNA (mRNA)
4. Complement Factor B (Factor B)
5. Methylmalonic acidemia
6. Anaphylatoxins
7. Cytokines
8. Interleukin-17 (Interleukin 27)
9. GTP-Binding Proteins (G-Protein)
10. Macrophage Colony-Stimulating Factor

Related Therapies and Procedures

1. Liver Transplantation
2. Surgical Instruments (Clip)