Complement C3d (Complement 3d)

A 302-amino-acid fragment in the alpha chain (672-1663) of C3b. It is generated when C3b is inactivated (iC3b) and its alpha chain is cleaved by COMPLEMENT FACTOR I into C3c, and C3dg (955-1303) in the presence COMPLEMENT FACTOR H. Serum proteases further degrade C3dg into C3d (1002-1303) and C3g (955-1001).

Also Known As:

Complement 3d; C3d Complement; Complement C3d Fragment; Complement Component 3d; C3d Fragment, Complement; C3d, Complement; Complement, C3d; Component 3d, Complement; Fragment, Complement C3d

Networked: 29 relevant articles (1 outcomes, 3 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Blood Proteins: 12459
    - Immunoproteins: 43
      - Complement System Proteins: 33379
        Complement C3: 1636
        Complement C3b: 199
        Complement C3d: 29

Experts

1.	Abbott, Jordan K: 1 article (07/2022)
2.	Bonifacino, Juan S: 1 article (07/2022)
3.	Crosby, Kevin: 1 article (07/2022)
4.	Deterding, Robin R: 1 article (07/2022)
5.	Elsegeiny, Waleed: 1 article (07/2022)
6.	Gelfand, Erwin W: 1 article (07/2022)
7.	Guardia, Carlos M: 1 article (07/2022)
8.	Hauk, Pia J: 1 article (07/2022)
9.	Hu, Guowu: 1 article (07/2022)
10.	Knight, Vijaya: 1 article (07/2022)

Related Diseases

1.	Necrosis 02/01/2005 - "However, kidneys from patients with acute tubular necrosis had C3d complement deposition along a significantly greater number of tubules, and many of the tubules were completely circumscribed. "
2.	HIV Infections (HIV Infection) 01/01/2020 - "Association of complement C3d receptor 2 genotypes with the acquisition of HIV infection in a trial of recombinant glycoprotein 120 vaccine."
3.	B-Cell Chronic Lymphocytic Leukemia (Chronic Lymphocytic Leukemia) 07/31/1976 - "A study of lymphocytes bearing C3b, C4b and C3d complement receptor (CRL) was performed on human peripheral blood from 16 healthy donors and 12 patients affected with Chronic Lymphatic Leukemia (CLL). "
4.	Neoplasms (Cancer) 09/01/1996 - "In a recent immunohistochemical study, we reported that immunoglobulin (IgG) and complement (C3d, C4d and C5) are specifically deposited in PTC tumor tissue. "
5.	Epstein-Barr Virus Infections 01/01/1991 - "We recently found evidence of persistent EBV infection in human ocular MALT and hypothesized that the epithelia in these tissues may also express the complement (C3d)/EBV receptor. " 06/01/1987 - "Epstein-Barr virus (EBV) infection of human B lymphocytes involves a specific receptor closely associated with, or identical to, the C3d complement receptor, CR2. "

Related Drugs and Biologics

1.	Immunoglobulins (Immunoglobulin)
2.	Immunoglobulin G (IgG)
3.	Vaccines
4.	Glycoproteins (Glycoprotein)
5.	Antigen-Antibody Complex (Immune Complex)
6.	Complement System Proteins (Complement)
7.	Basic Helix-Loop-Helix Transcription Factors
8.	I-kappa B Kinase
9.	Eosinophil Cationic Protein
10.	A-Form DNA (A-DNA)

Related Therapies and Procedures

1.	Artificial Respiration (Mechanical Ventilation)
2.	Drug Therapy (Chemotherapy)