Complement C3a (Complement 3a)

The smaller fragment generated from the cleavage of complement C3 by C3 CONVERTASE. C3a, a 77-amino acid peptide, is a mediator of local inflammatory process. It induces smooth MUSCLE CONTRACTION, and HISTAMINE RELEASE from MAST CELLS and LEUKOCYTES. C3a is considered an anaphylatoxin along with COMPLEMENT C4A; COMPLEMENT C5A; and COMPLEMENT C5A, DES-ARGININE.

Also Known As:

Complement 3a; C3a Complement; Complement Component 3a; C3a, Complement; Complement, C3a; Component 3a, Complement

Networked: 88 relevant articles (4 outcomes, 5 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Blood Proteins: 12459
    - Immunoproteins: 43
      - Complement System Proteins: 33379
        Complement C3: 1636
        Complement C3a: 88
        des-Arg-(77)- complement C3a: 94
        (57-77) complement C3a
        (70-77) complement C3a
        (72-77) complement C3a
        (Tyr-70-77) complement C3a
        Anaphylatoxins: 563
        Complement C3a: 88
        des-Arg-(77)- complement C3a: 94
        (57-77) complement C3a
        (70-77) complement C3a
        (72-77) complement C3a
        (Tyr-70-77) complement C3a

Experts

1.	Zhao, Ming-Hui: 3 articles (07/2022 - 01/2017)
2.	Cui, Zhao: 2 articles (07/2022 - 01/2020)
3.	Gao, Shuang: 2 articles (07/2022 - 01/2020)
4.	Zhang, Li: 2 articles (06/2022 - 05/2012)
5.	Kim, Yu Mi: 2 articles (11/2021 - 08/2018)
6.	Park, Kyo Hoon: 2 articles (11/2021 - 08/2018)
7.	Ducruet, Andrew F: 2 articles (01/2021 - 08/2007)
8.	Bartolomucci, Alessandro: 2 articles (09/2019 - 01/2017)
9.	Cero, Cheryl: 2 articles (09/2019 - 01/2017)
10.	Han, Ruijun: 2 articles (09/2019 - 01/2017)

Related Diseases

1.	Ischemia 04/15/2002 - "Expression of the complement C3a and C5a receptors after permanent focal ischemia: An alternative interpretation." 03/27/2023 - "The aim of this study was to explore the mechanism of complement C3a mediating podocyte injury during ischemia-reperfusion acute kidney injury (IR-AKI) and post-injury fibrosis. " 09/15/2000 - "Moreover, complement C3a improved scopolamine- and ischemia-induced amnesia at a dose of 10 pmol/mouse. "
2.	Necrosis 05/01/2016 - "Postmortem donor eyes were genotyped for the CFH Y402H polymorphism and assessed for complement C3a, C5a, interleukin (IL)-18 and tumour necrosis factor (TNF)-α. " 03/01/2014 - "Complement C3a and C5a and cytokines (interleukin (IL)-2, IL-4, IL-6, IL-10, tumour necrosis factor, interferon-γ and IL-17a) were measured in 20 acute TTP patients and 49 remission cases. " 10/01/1997 - "Levels of activated complement C3a and tumour necrosis factor-alpha did not change, but levels of interleukin (IL)-6, IL-8 and elastase-alpha 1-antitrypsin increased. "
3.	Lung Injury 07/01/2014 - "C1-inhibitor reduced pulmonary levels of complement C3a associated with improved lung injury scores. "
4.	Amnesia (Dissociative Amnesia) 09/15/2000 - "Moreover, complement C3a improved scopolamine- and ischemia-induced amnesia at a dose of 10 pmol/mouse. "
5.	Acute Disease 01/01/2017 - "Compared to patients in remission and normal control subjects, patients with acute disease had significantly lower plasma CFH levels and significantly higher plasma complement 3a (C3a), C5a, and terminal complement complex (SC5b-9) levels. "

Related Drugs and Biologics

1.	Interleukins
2.	Cytokines
3.	Complement Membrane Attack Complex (Membrane Attack Complex)
4.	Scopolamine (Hyoscine)
5.	Interferons
6.	thiamine triphosphorate (TTP)
7.	Interleukin-6 (Interleukin 6)
8.	C-Reactive Protein
9.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
10.	Neuropeptides

Related Therapies and Procedures

1.	Therapeutics
2.	Cardiac Resynchronization Therapy
3.	Radiotherapy
4.	Plasmapheresis