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Complement C1r (Complement Component 1r)

A 80-kDa subcomponent of complement C1, existing as a SERINE PROTEASE proenzyme in the intact complement C1 complex. When COMPLEMENT C1Q is bound to antibodies, the changed tertiary structure causes autolytic activation of complement C1r which is cleaved into two chains, A (heavy) and B (light, the serine protease), connected by disulfide bonds. The activated C1r serine protease, in turn, activates COMPLEMENT C1S proenzyme by cleaving the Arg426-Ile427 bond. No fragment is released when either C1r or C1s is cleaved.
Also Known As:
Complement Component 1r; C1r Complement; Complement 1r; C1r, Complement; Complement, C1r; Component 1r, Complement
Networked: 8 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Experts

1. Yang, Cheng-Ning: 1 article (12/2015)
2. Chen, Szu-Ta: 1 article (12/2015)
3. Chou, Chiang-Ting: 1 article (12/2015)
4. Li, Pei-Shan: 1 article (12/2015)
5. Li, Yue-Ju: 1 article (12/2015)
6. Jeng, Yung-Ming: 1 article (12/2015)
7. Lin, I-Ching: 1 article (12/2015)
8. Chang, Cheng-Chi: 1 article (12/2015)
9. Kuo, Min-Liang: 1 article (12/2015)
10. Lin, Been-Ren: 1 article (12/2015)

Related Diseases

1. Neoplasm Metastasis (Metastasis)
2. Acute Coronary Syndrome
3. Stroke (Strokes)
4. Neoplasms (Cancer)
5. Colorectal Neoplasms (Colorectal Cancer)

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2. Epidermal Growth Factor (EGF)
3. LDL Receptors (LDL Receptor)
4. Malondialdehyde (Propanedial)
5. Glycoproteins (Glycoprotein)
6. matriptase
7. trypsin-like serine protease

Related Therapies and Procedures

1. Orchiectomy (Orchidectomy)